公开(公告)号：EP2821402A4

公开(公告)日：2015-08-19

申请号：EP13754501

申请日：2013-02-26

申请人： ASTELLAS PHARMA INC ,  KOTOBUKI PHARMACEUTICAL CO LTD

发明人： KAMEDA MINORU ,  KURIWAKI IKUMI ,  IIKUBO KAZUHIKO ,  HISAMICHI HIROYUKI ,  KAWAMOTO YUICHIRO ,  MORITOMO HIROYUKI ,  SUZUKI TOMOYUKI ,  FUTAMI TAKASHI ,  SUZUKI ATSUSHI ,  TSUNOYAMA KAZUHISA ,  ASAUMI MAKOTO ,  TOMIYAMA HIROSHI ,  NODA ATSUSHI ,  IWAI YOSHINORI ,  TOKUZAKI KAZUO ,  OKADA HARUKI ,  MIYASAKA KOZO

IPC分类号： C07D239/42 ,  A61K31/4545 ,  A61K31/506 ,  A61P35/00 ,  A61P43/00 ,  C07D239/47 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D471/10 ,  C07D487/20

CPC分类号： C07D239/47 ,  C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D451/04 ,  C07D453/02 ,  C07D471/08 ,  C07D471/10 ,  C07D487/10 ,  C07D491/107

摘要： Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.

公开(公告)号：EP2599774A4

公开(公告)日：2014-01-08

申请号：EP11812552

申请日：2011-07-28

申请人： ASTELLAS PHARMA INC

发明人： MATSUSHIMA YUJI ,  KAMEDA MINORU ,  HONDA SHUGO ,  SUGANO YUKIHITO ,  USUDA HIROYUKI ,  TERASAKA TADASHI ,  TERASAWA TAKESHI ,  NISHIGAKI FUSAKO

IPC分类号： C07D217/26 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/553 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D237/34 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D495/04

CPC分类号： C07D217/26 ,  C07D217/22 ,  C07D217/24 ,  C07D221/04 ,  C07D221/06 ,  C07D221/16 ,  C07D237/26 ,  C07D237/34 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D495/04