公开(公告)号：EP0279150A1

公开(公告)日：1988-08-24

申请号：EP87850388.7

申请日：1987-12-16

申请人： ASTRA LAKEMEDEL AKTIEBOLAG

发明人： Häll, Hakan Olof ,  Johansson, Lars George ,  Thorberg, Seth Olov

IPC分类号： C07D311/58 ,  A61K31/35

CPC分类号： C07D311/58

摘要： A compound of the formula
wherein R¹ is a saturated or unsaturated alkyl group having 1-5 carbon atoms or a phenylalkyl group, whereby the phenyl ring may be substituted or unsubstituted and the alkyl having 1-4 carbon atoms, R² is hydrogen or an alkyl group having 1-5 carbon atoms, or R¹ and R² together form a 5- or 6-membered ring containing 1 or 2 heteroatoms selected from N, O and S, and enantiomers and physiologically acceptable salts thereof, processes for preparation of said compounds, pharmaceutical preparations containing said compounds, use of and method of treatment of disorders in CNS by using said compounds and intermediates.

摘要翻译： 式 worin - [R <1>所述的化合物是具有1-5个碳原子或苯基烷基，其中所述苯环可以是substituiertem奥德unsubstituiertem和具有1至4个碳原子的烷基的饱和或不饱和烷基， [R <2>为碳原子的1-5个氢或烷基，或者R <1>和R <2>一起形成5-或6-元环含有选自N，O和S中的1或2个杂原子， 和对映体和生理上可接受的盐，其处理用于制备所述化合物，药物制剂通过使用所述化合物和中间体含有所述化合物，用和治疗CNS障碍的方法。