-
1.发明公开BCL-XL INHIBITORY COMPOUNDS AND ANTIBODY DRUG CONJUGATES INCLUDING THE SAME 审中-公开BCL-XL抑制化合物和抗体药物偶联物，包括相同
公开(公告)号：EP3230283A1
公开(公告)日：2017-10-18
申请号：EP15823857.6
申请日：2015-12-09
申请人： AbbVie Inc.
发明人： TAO, Zhi-Fu , DOHERTY, George , WANG, Xilu , SULLIVAN, Gerard M. , SONG, Xiaohong , KUNZER, Aaron R. , WENDT, Michael D. , FREY, Robin R. , CULLEN, Steve C. , WELCH, Dennie S. , SHEN, Xiaoqiang , BENNETT, Nathan B. , HAIGHT, Anthony R. , ACKLER, Scott L. , BOGHAERT, Erwin R. , SOUERS, Andrew J. , JUDD, Andrew S.
IPC分类号： C07D417/14 , C07D513/04 , A61K31/428 , A61K31/429 , A61P35/00
CPC分类号： C07K16/18 , A61K47/6803 , C07D417/14 , C07D487/04 , C07D513/04 , C07K2317/73
摘要： Small molecule Bcl-xL inhibitorsand Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
摘要翻译： 本文公开了包含小分子Bcl-xL抑制剂的小分子Bcl-xL抑制剂和抗体药物偶联物（ADCs）。 本公开的Bcl-xL抑制剂和ADC可用于（尤其）抑制抗凋亡Bcl xL蛋白作为治疗涉及凋亡途径失调的疾病的治疗方法。
-
公开(公告)号：EP3229844B1
公开(公告)日：2020-03-04
申请号：EP15819955.4
申请日：2015-12-09
申请人： AbbVie Inc.
发明人： BOGHAERT, Erwin R. , ACKLER, Scott L. , TAO, Zhi-Fu , WANG, Xilu , DOHERTY, George , MARIN, Violeta L. , SULLIVAN, Gerard M. , SONG, Xiaohong , KUNZER, Aaron R. , WELCH, Dennie S. , BRUNCKO, Milan , JUDD, Andrew S. , SOUERS, Andrew J.
IPC分类号： A61K47/68 , A61P43/00 , A61P35/00 , A61K31/4545
-
3.发明授权8-CARBAMOYL-2-(2,3-DISUBSTITUTED PYRID-6-YL)-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AS APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权8-氨基甲酰基-2-（2,3-二取代的吡啶-6-基）-1,2,3,4-四氢异喹啉衍生物作为细胞凋亡FOR治疗癌症的诱导剂，以及免疫和自身免疫疾病
公开(公告)号：EP2766361B1
公开(公告)日：2016-08-10
申请号：EP12780605.7
申请日：2012-10-11
申请人： AbbVie Inc.
发明人： WANG, Le , DOHERTY, George , WANG, Xilu , TAO, Zhi-Fu , BRUNKO, Milan , KUNZER, Aaron R. , WENDT, Michael D. , SONG, Xiaohong , FREY, Robin , HANSEN, Todd M. , SULLIVAN, Gerard M. , JUDD, Andrew , SOUERS, Andrew
IPC分类号： C07D417/14 , C07D513/04 , C07D471/04 , C07D487/04 , A61K31/4725 , A61P35/00
CPC分类号： C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
-
4.发明公开BCL XL INHIBITORY COMPOUNDS HAVING LOW CELL PERMEABILITY AND ANTIBODY DRUG CONJUGATES INCLUDING THE SAME 审中-公开具有低细胞渗透性和抗体药物偶联物的BCL XL抑制化合物，包括相同的
公开(公告)号：EP3230282A1
公开(公告)日：2017-10-18
申请号：EP15813671.3
申请日：2015-12-09
申请人： AbbVie Inc.
发明人： TAO, Zhi-Fu , DOHERTY, George , WANG, Xilu , SULLIVAN, Gerard M. , SONG, Xiaohong , KUNZER, Aaron R. , WENDT, Michael D. , MARIN, Violeta L. , FREY, Robin R. , CULLEN, Steve C. , WELCH, Dennie S. , SHEN, Xiaoqiang , BENNETT, Nathan B. , HAIGHT, Anthony R. , ACKLER, Scott L. , BOGHAERT, Erwin R. , SOUERS, Andrew J. , JUDD, Andrew S.
IPC分类号： C07D417/14 , C07D513/04 , A61K31/428 , A61K31/429 , A61P35/00
CPC分类号： A61K47/48715 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , A61K31/538 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6883 , A61K47/6889 , C07D417/14 , C07D487/04 , C07D513/04
摘要： The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.
摘要翻译： 本公开涉及具有低细胞渗透性的Bcl-xL抑制剂，包含所述抑制剂的抗体药物缀合物（ADC），用于合成ADC的合成子，包含所述抑制剂或ADC的组合物，以及使用所述抑制剂和ADC的各种方法。
-
5.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开APOPTOSEINDUKTORENFÜRDIE BEHANDLUNG VON KREBS SOWIE IMMUN- UND AUTOIMMUNERKRANKUNGEN
公开(公告)号：EP2768830A1
公开(公告)日：2014-08-27
申请号：EP12778012.0
申请日：2012-10-11
申请人： AbbVie Inc.
发明人： WANG, Le , DOHERTY, George , WANG, Xilu , TAO, Zhi-Fu , BRUNKO, Milan , KUNZER, Aaron R. , WENDT, Michael D. , SONG, Xiaohong , FREY, Robin , HANSEN, Todd M. , SULLIVAN, Gerard M. , JUDD, Andrew , SOUERS, Andrew
IPC分类号： C07D417/14
CPC分类号： C07D417/14 , A61K45/06
摘要： Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and compounds (I) for use in the methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
摘要翻译： 公开了具有抑制抗凋亡性Bcl-xL蛋白的活性的式（I）化合物，含有该化合物的组合物和治疗其中表达抗凋亡Bcl-xL蛋白的疾病的方法。
-
公开(公告)号：EP2768830B1
公开(公告)日：2018-08-29
申请号：EP12778012.0
申请日：2012-10-11
申请人： AbbVie Inc.
发明人： WANG, Le , DOHERTY, George , WANG, Xilu , TAO, Zhi-Fu , BRUNKO, Milan , KUNZER, Aaron R. , WENDT, Michael D. , SONG, Xiaohong , FREY, Robin , HANSEN, Todd M. , SULLIVAN, Gerard M. , JUDD, Andrew , SOUERS, Andrew
IPC分类号： C07D417/14 , A61K31/428 , A61P35/00
CPC分类号： C07D417/14 , A61K45/06
摘要： Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and compounds (I) for use in the methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
-
7.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开细胞凋亡诱导剂治疗癌症和免疫及自身免疫疾病
公开(公告)号：EP3266776A1
公开(公告)日：2018-01-10
申请号：EP17185702.2
申请日：2012-10-11
申请人： AbbVie Inc.
发明人： WANG, Le , DOHERTY, George , WANG, Xilu , TAO, Zhi-Fu , BRUNKO, Milan , KUNZER, Aaron R. , WENDT, Michael D. , SONG, Xiaohong , FREY, Robin , HANSEN, Todd M. , SULLIVAN, Gerard M. , JUDD, Andrew , SOUERS, Andrew
IPC分类号： C07D417/14 , A61K31/4725 , A61K31/428 , A61P35/00
CPC分类号： C07D417/14 , A61K45/06
摘要： Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and compounds (I) for use in the methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
摘要翻译： 公开了抑制抗凋亡Bcl-xL蛋白质活性的化合物（I），含有该化合物和化合物（I）的组合物用于治疗表达抗凋亡Bcl-xL蛋白质的疾病的方法中。
-
公开(公告)号：EP3229844A1
公开(公告)日：2017-10-18
申请号：EP15819955.4
申请日：2015-12-09
申请人： AbbVie Inc.
发明人： BOGHAERT, Erwin R. , ACKLER, Scott L. , TAO, Zhi-Fu , WANG, Xilu , DOHERTY, George , MARIN, Violeta L. , SULLIVAN, Gerard M. , SONG, Xiaohong , KUNZER, Aaron R. , WELCH, Dennie S. , BRUNCKO, Milan , JUDD, Andrew S. , SOUERS, Andrew J.
CPC分类号： A61K31/4545 , A61K47/6803 , A61K47/6807 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6889
摘要： Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
摘要翻译： 本文公开了包含小分子Bcl-xL抑制剂的小分子Bcl-xL抑制剂和抗体药物偶联物（ADCs）。 本公开的Bcl-xL抑制剂和ADC可用于（尤其）抑制抗凋亡Bcl xL蛋白作为治疗涉及凋亡途径失调的疾病的治疗方法。
-
9.发明公开8 - CARBAMOYL - 2 - (2,3- DI SUBSTITUTED PYRID - 6 - YL) -1,2,3,4 -TETRAHYDROISOQUINOLINE DERIVATIVES AS APOPTOSIS - INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权8-氨基甲酰基-2-（2,3-二取代的吡啶-6-基）-1,2,3,4-四氢异喹啉衍生物作为细胞凋亡FOR治疗癌症的诱导剂，以及免疫和自身免疫疾病
公开(公告)号：EP2766361A1
公开(公告)日：2014-08-20
申请号：EP12780605.7
申请日：2012-10-11
申请人： AbbVie Inc.
发明人： WANG, Le , DOHERTY, George , WANG, Xilu , TAO, Zhi-Fu , BRUNKO, Milan , KUNZER, Aaron R. , WENDT, Michael D. , SONG, Xiaohong , FREY, Robin , HANSEN, Todd M. , SULLIVAN, Gerard M. , JUDD, Andrew , SOUERS, Andrew
IPC分类号： C07D417/14 , C07D513/04 , C07D471/04 , C07D487/04 , A61K31/4725 , A61P35/00
CPC分类号： C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y
1 is phenylene or heteroarylene; L
1 is a linker; Y
2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z
1 is C(0)OR
9 , C(O)NR
10 R
11 , C(0)R
11 , NR
10 C(O)R
11 , etc.-
10.发明公开
公开(公告)号：EP2576546A1
公开(公告)日：2013-04-10
申请号：EP10784398.9
申请日：2010-11-22
申请人： Abbvie Inc.
发明人： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd, M.
IPC分类号： C07D471/04 , A61K31/437 , A61K35/00
CPC分类号： C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.043 秒)
