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1.发明授权SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 有权磺胺ALS BCL-2选择性诱导细胞凋亡的手段治疗癌症和免疫系统疾病的
公开(公告)号：EP2376480B1
公开(公告)日：2016-06-01
申请号：EP09795606.4
申请日：2009-12-04
申请人： AbbVie Inc.
发明人： BRUNCKO, Milan , DING, Hong , DOHERTY, George, A. , ELMORE, Steven, W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron, R. , MANTEI, Robert, A. , MCCLELLAN, William, J. , PARK, Chang, H. , PARK, Cheol-min , PETROS, Andrew, M. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael, D.
IPC分类号： C07D405/12 , A61K31/404 , A61P35/00 , C07D309/14 , C07D215/20 , C07D217/16 , C07D231/56 , C07D401/12 , C07D235/26 , C07D417/12 , C07D249/04 , C07D209/32 , C07D295/125 , C07D295/14 , C07D211/96 , C07D213/64
CPC分类号： C07D405/12 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D417/12
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2.发明授权APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权凋亡诱导剂治疗癌症和免疫和自身免疫性疾病
公开(公告)号：EP2376197B1
公开(公告)日：2017-02-15
申请号：EP09768289.2
申请日：2009-12-04
发明人： BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George, A. , ELMORE, Steven, W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron, R. , MANTEI, Robert, A. , MCCLELLAN, William, J. , PARK, Chang, H. , PARK, Cheol-Min , PETROS, Andrew, M. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael, D. , CZABOTAR, Peter Edward , LESSENE, Guillaume Laurent , COLMAN, Peter Malcom
IPC分类号： A61P35/00 , A61K31/496 , C07D403/12
CPC分类号： C07D405/12 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
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3.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开APOPTOSEINDUKTOREN ZUR BEHANDLUNG冯KREBS SOWIE VON IMMUN- UND AUTOIMMUNERKRANKUNGEN
公开(公告)号：EP3112361A1
公开(公告)日：2017-01-04
申请号：EP16175661.4
申请日：2009-12-04
发明人： BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George, A. , ELMORE, Steven, W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron, R. , MANTEI, Robert, A. , MCCLELLAN, William, J. , PARK, Chang, H. , PARK, Cheol-Min , PETROS, Andrew, M. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael, D. , CZABOTAR, Peter Edward , LESSENE, Guillaume Laurent , COLMAN, Peter Malcom
IPC分类号： C07D401/14 , C07D405/14 , C07D213/74 , C07D309/04 , C07D213/84 , C07D235/06 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D277/24 , C07D209/08 , C07D211/58 , C07D295/30 , A61P35/00 , A61K31/496 , C07D231/56
CPC分类号： C07D405/12 , C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗其中表达抗凋亡Bcl-2蛋白的疾病的方法。
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4.发明公开SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 审中-公开苏氨酸衍生物ALS BCL-2-SELEKTIVE APOPTOSEINDUKTOREN ZUR BEHANDLUNG VON KREBS SOWIE VON IMMUNERKRANKUNGEN
公开(公告)号：EP3101019A1
公开(公告)日：2016-12-07
申请号：EP16169764.4
申请日：2009-12-04
申请人： AbbVie Inc.
发明人： BRUNCKO, Milan , DING, Hong , DOHERTY, George, A. , ELMORE, Steven, W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron, R. , MANTEI, Robert, A. , MCCLELLAN, William, J. , PARK, Chang, H. , PARK, Cheol-min , PETROS, Andrew, M. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael, D.
IPC分类号： C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D235/26 , C07D249/04 , C07D295/14 , C07D309/14 , C07D401/12 , C07D295/125
CPC分类号： C07D405/12 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D417/12
摘要： Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白活性的式（I）化合物，含有该化合物的组合物和治疗其中表达抗凋亡Bcl-2蛋白的疾病的方法。
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