公开(公告)号：EP1268481B1

公开(公告)日：2007-12-12

申请号：EP00963510.3

申请日：2000-09-15

申请人： Abbott GmbH & Co. KG

发明人： HIRST, Gavin, C. ,  RITTER, Kurt ,  RAFFERTY, Paul ,  ST.GALLAY, Stephen ,  CALDERWOOD, David ,  TWIGGER, Helen, L.

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D491/04 ,  C07D498/04 ,  A61K31/519 ,  A61K31/5025 ,  A61K31/4353 ,  A61K31/551 ,  A61P35/00 ,  C07D239/00 ,  C07D209/00 ,  C07D237/00 ,  C07D231/00 ,  C07D221/00 ,  C07D243/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07F9/6561

摘要： The present invention is directed to a compound of Formula (I) as defined herein which are useful as kinase inhibitors.

公开(公告)号：EP1114052B1

公开(公告)日：2005-11-16

申请号：EP99969414.4

申请日：1999-09-17

申请人： Abbott GmbH & Co. KG

发明人： CALDERWOOD, David ,  ARNOLD, Lee, D. ,  MAZDIYASNI, Hormoz ,  HIRST, Gavin ,  DENG, Bojuan, B. ,  TWIGGER, Helen, L. ,  MUNSCHAUER, Rainer ,  RAFFERTY, Paul ,  TOMETZKI, Gerald, B. ,  JOHNSTON, David, N.

IPC分类号： C07D487/04 ,  A61K31/505

CPC分类号： C07D487/04

摘要： Chemical compounds having structural formula (I) and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases whose activity is inhibited by these compounds are involved in immunologic, hyperproliferative or angiogenic processes. Thus, these compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferative is a factor. These compounds can be used to treat cancer, hyperproliferation disorders, rheumatoid arthritis, disorders of the immune system, transplant rejection, and inflammatory disorders.