公开(公告)号：EP1027362A1

公开(公告)日：2000-08-16

申请号：EP98956338.2

申请日：1998-10-29

申请人： Abbott Laboratories

发明人： PHAN, LY, Tam ,  OR, Yat, Sun ,  CHU, Daniel, T. ,  PLATTNER, Jacob, J. ,  CHEN, Yan ,  CLARK, Richard, F.

IPC分类号： C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08 ,  Y02P20/55

摘要： Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：EP0929563A1

公开(公告)日：1999-07-21

申请号：EP97939765.0

申请日：1997-09-02

申请人： Abbott Laboratories

发明人： OR, Yat, Sun ,  MA, Zhenkun ,  CLARK, Richard, F. ,  CHU, Daniel, T. ,  PLATTNER, Jacob, J.

IPC分类号： A61K31 ,  A61P31 ,  C07H17

CPC分类号： C07H17/08 ,  Y02P20/55

摘要： Antimicrobial compounds having formula (II), (III), (IV), (IV-A) or (V) as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compunds.

公开(公告)号：EP0918783A1

公开(公告)日：1999-06-02

申请号：EP97916157.0

申请日：1997-03-21

申请人： ABBOTT LABORATORIES

发明人： OR, Yat, Sun ,  CHU, Daniel, T. ,  CLARK, Richard, F. ,  MA, Zhenkun

IPC分类号： A61K31 ,  A61P31 ,  C07H17

CPC分类号： C07H17/08

摘要： Antimicrobial compounds having formula (II), (III), (IV), (V), (VI), (VII), (VIII) and (IX) as well as the pharmaceutically acceptable salts, esters and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

公开(公告)号：EP2435436A1

公开(公告)日：2012-04-04

申请号：EP10727228.8

申请日：2010-05-26

申请人： Abbott Laboratories

发明人： CLARK, Richard, F. ,  BELL, Randy, L. ,  BA-MAUNG, Nwe, Y. ,  ERICKSON, Scott, A. ,  FIDANZE, Steve, D. ,  MANTEI, Robert, A. ,  SHEPPARD, George, S. ,  SORENSEN, Bryan, K. ,  WANG, Gary, T. ,  WANG, Jieyi

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D513/04

摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G
1 , R
2 , R
3 , R
4 , R
5 , n, p, q, Ar
1 , and Ar
2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-IR.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐或溶剂合物，其中G 1，R 2，R 3，R 4，R 5，n，p，q，Ar 1和Ar 2定义为 说明。 本发明还涉及制备所述化合物的方法，以及包含所述化合物的组合物，其可用于抑制激酶如IGF-1R。

公开(公告)号：EP1501845A1

公开(公告)日：2005-02-02

申请号：EP03721887.2

申请日：2003-04-25

申请人： Abbott Laboratories

发明人： CLARK, Richard, F. ,  DJURIC, Stevan, M. ,  MA, Zhenkun ,  PHAN, Ly ,  RUPP, Michael, J.

IPC分类号： C07H17/08 ,  A61K31/7048 ,  A61P31/04

CPC分类号： C07H17/08

摘要： Antibacterial compounds with improved pharmacokinetic profiles having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis and treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：EP1017706A1

公开(公告)日：2000-07-12

申请号：EP98947047.1

申请日：1998-09-15

申请人： Abbott Laboratories

发明人： OR, Yat, Sun ,  CLARK, Richard, F. ,  CHU, Daniel, T.

IPC分类号： C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08

摘要： Disclosed are the antibacterial compounds having formulas (I) or (II) or pharmaceutically acceptable salts and esters thereof. Also disclosed are the processes for preparing compounds of formulas (I), and (II) of the invention, pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention in combination with pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.

公开(公告)号：EP1027362B1

公开(公告)日：2005-06-29

申请号：EP98956338.2

申请日：1998-10-29

申请人： Abbott Laboratories

发明人： PHAN, LY, Tam ,  OR, Yat, Sun ,  CHU, Daniel, T. ,  PLATTNER, Jacob, J. ,  CHEN, Yan ,  CLARK, Richard, F.

IPC分类号： C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08 ,  Y02P20/55

摘要： Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：EP1328534A2

公开(公告)日：2003-07-23

申请号：EP01981637.0

申请日：2001-10-16

申请人： Abbott Laboratories

发明人： MA, Zhenkun ,  PHAM, Ly, Tam ,  CLARK, Richard, F. ,  ZHANG, Souming ,  DJURIC, Stevan

IPC分类号： C07H17/08 ,  A61K31/7048 ,  A61P31/04

CPC分类号： C07H17/08

摘要： Compounds having formula (I) are useful for treating bacterial infections while avoiding the concomitant liability of gastrointestinal intolerance. Compositions containing the compounds and methods of treatment using the compounds are also disclosed.

公开(公告)号：EP1161438A1

公开(公告)日：2001-12-12

申请号：EP00913805.8

申请日：2000-03-08

申请人： ABBOTT LABORATORIES

发明人： OR, Yat, Sun ,  CLARK, Richard, F. ,  MA, Zhenkun ,  RUPP, Michael, J.

IPC分类号： C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08

摘要： The instant invention provides novel macrolide compounds and compositions useful in treating bacterial infections. Also provided are processes for preparing same. These macrolides are substituted on the 6-O-position with X'-Y'-Z', wherein X' is selected from the group consisting of C1-C10 alkyl, C3-C10 alkenyl, and C3-C10 alkynyl; Y' and Z' are independently selected from the group consisting of: (c) optionally substituted aryl, and (d) optionally substituted heteroaryl, with the proviso that both Y' and Z' are not both phenyl, and with the further proviso that Y' is not isoxazole when Z' is thiophenyl.

公开(公告)号：EP0929563B1

公开(公告)日：2005-06-01

申请号：EP97939765.0

申请日：1997-09-02

申请人： Abbott Laboratories

发明人： OR, Yat, Sun ,  MA, Zhenkun ,  CLARK, Richard, F. ,  CHU, Daniel, T. ,  PLATTNER, Jacob, J.

IPC分类号： C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08 ,  Y02P20/55

摘要： Antimicrobial compounds having formula (II), (III), (IV), (IV-A) or (V) as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compunds.