公开(公告)号：EP2373163A1

公开(公告)日：2011-10-12

申请号：EP09837920.9

申请日：2009-12-17

申请人： Genentech, Inc. ,  The Walter and Eliza Hall Institute of Medical Research ,  Abbott Laboratories

发明人： BAELL, Jonathan, Bayldon ,  BUI, Chinh, Thien ,  COLMAN, Peter ,  CZABOTAR, Peter ,  DUDLEY, Danette, A. ,  FAIRBROTHER, Wayne, J. ,  FLYGARE, John, A. ,  LESSENE, Guillaume, Laurent ,  NDUBAKU, Chudi ,  NIKOLAKOPOULOS, George ,  SLEEBS, Brad, Edmund ,  SMITH, Brian, John ,  WATSON, Keith, Geoffrey ,  ELMORE, Steven, W. ,  HASVOLD, Lisa, A. ,  PETROS, Andrew, M. ,  SOUERS, Andrew, J. ,  TAO, Zhi-Fu ,  WANG, Le ,  WANG, Xilu ,  DESHAYES, Kurt

IPC分类号： A01N43/00

CPC分类号： C07D417/14 ,  C07D471/06 ,  C07D473/00 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  C07D513/06

摘要： In one aspect, the present invention provides for a compound of Formula I; in which the variable X
1a , X
1b , X
1c , X
1d , Q, A, R
1 , B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-x
L proteins.

公开(公告)号：EP2134684A2

公开(公告)日：2009-12-23

申请号：EP08745970.7

申请日：2008-04-16

申请人： Abbott Laboratories

发明人： ELMORE, Steven, W. ,  SOUERS, Andrew, J. ,  BRUNCKO, Milan ,  SONG, Xiaohong ,  WANG, Xilu ,  HASVOLD, Lisa, A. ,  WANG, Le ,  KUNZER, Aaron, R. ,  PARK, Cheol-min ,  WENDT, Michael, D. ,  TAO, Zhi-fu ,  MADAR, David

IPC分类号： C07D209/34 ,  C07D401/12 ,  C07D413/06 ,  C07D417/04 ,  A61P35/00 ,  A61K31/404

CPC分类号： C07D209/42 ,  A61K31/5377 ,  C07D209/34 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D491/113

摘要： Compounds of formula (I) which inhibit the activity of anti-apoptotic McI-I protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated McI-I protein are disclosed.

摘要翻译： 公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。

公开(公告)号：EP1339695A1

公开(公告)日：2003-09-03

申请号：EP01273519.7

申请日：2001-11-30

申请人： Abbott Laboratories

发明人： CLAIBORNE, Akiyo, K. ,  GWALTNEY, Stephen, L, II ,  HASVOLD, Lisa, A. ,  LI, Qun ,  LI, Tomgmei ,  LIN, Nan-Horng ,  MANTEI, Robert, A. ,  ROCKWAY, Todd, W. ,  SHAM, Hing, L. ,  SULLIVAN, Gerard, M. ,  TONG, Yunsong ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WANG, Weibo

IPC分类号： C07D233/64 ,  A61K31/4164 ,  C07D401/12 ,  A61P35/00

CPC分类号： C07D233/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

摘要： Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

公开(公告)号：EP1339695B1

公开(公告)日：2006-04-19

申请号：EP01273519.7

申请日：2001-11-30

申请人： ABBOTT LABORATORIES

发明人： CLAIBORNE, Akiyo, K. ,  GWALTNEY, Stephen, L, II ,  HASVOLD, Lisa, A. ,  LI, Qun ,  LI, Tomgmei ,  LIN, Nan-Horng ,  MANTEI, Robert, A. ,  ROCKWAY, Todd, W. ,  SHAM, Hing, L. ,  SULLIVAN, Gerard, M. ,  TONG, Yunsong ,  WANG, Gary, T. ,  WANG, Le ,  WANG, Xilu ,  WANG, Weibo

IPC分类号： C07D233/64 ,  A61K31/4164 ,  C07D401/12 ,  A61P35/00

CPC分类号： C07D233/64 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

摘要： Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.

摘要翻译： 具有式（I）的取代的咪唑和噻唑可用于抑制法尼基转移酶。 还公开了法尼基转移酶抑制组合物和抑制患者中法尼基转移酶的方法。

公开(公告)号：EP1606268A1

公开(公告)日：2005-12-21

申请号：EP04715097.4

申请日：2004-02-26

申请人： ABBOTT LABORATORIES

发明人： HASVOLD, Lisa, A. ,  HEXAMER, Laura ,  LI, Gaoquan ,  LIN, Nan-Horng ,  SHAM, Hing ,  SOWIN, Tom ,  SULLIVAN, Gerard, M. ,  WANG, Le ,  XIA, Ping Xia

IPC分类号： C07D243/38 ,  A61K31/551 ,  A61P35/00

CPC分类号： C07D243/38 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D491/10

摘要： Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.