公开(公告)号：EP1341820A2

公开(公告)日：2003-09-10

申请号：EP01273730.0

申请日：2001-12-05

申请人： Abbott Laboratories

发明人： LOU, Sheng, C. ,  HUNT, Jeffrey, C. ,  KONRATH, John, G. ,  QIU, Xiaoxing ,  SCHEFFEL, James, W. ,  TYNER, Joan, D.

IPC分类号： C07K16/10

CPC分类号： C07K16/1054 ,  C07K7/08 ,  C07K14/005 ,  C07K14/161 ,  C07K2317/34 ,  C12N2740/16211 ,  C12N2740/16222 ,  G01N33/56983 ,  G01N33/68

摘要： The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.

公开(公告)号：EP0836708A1

公开(公告)日：1998-04-22

申请号：EP96917969.0

申请日：1996-06-04

申请人： Abbott Laboratories

发明人： OKASINSKI, Gregory, F. ,  SCHAEFER, Verlyn, G. ,  SUHAR, Thomas, S. ,  LESNIEWSKI, Richard, R. ,  SCHEFFEL, James, W.

IPC分类号： C07K14 ,  C12N15 ,  G01N33

CPC分类号： C07K14/005 ,  C12N2770/24222 ,  G01N33/5767

摘要： A method for detecting antibody to HCV in a test sample. The method includes utilizing a recombinant protein that is the expression product of mammalian cells transformed by a heterologous expression vector comprising a DNA sequence encoding an E2 truncated protein. Test kits which include this recombinant protein also are provided.