公开(公告)号：EP3183578A1

公开(公告)日：2017-06-28

申请号：EP15757396.5

申请日：2015-08-21

申请人： Abbott Laboratories ,  Hvidovre Hospital, University of Copenhagen

发明人： DAVIS, Gerard J. ,  GAWEL, Susan H. ,  YANG, Xiaoqing ,  NIELSEN, Hans Jørgen ,  CHRISTENSEN, Ib Jarle

IPC分类号： G01N33/574 ,  C12Q1/68

摘要： Provided are methods of diagnosing high risk adenomas or colorectal cancer by detecting the presence and/or amount of at least three biomarkers of CRC in a sample from a subject. The methods and biomarkers may be used to develop an accurate prognosis for a patient having CRC or at risk of having CRC or accurately diagnose a subject having or at risk of having CRC. The methods and biomarkers may be used to identify and/or classify a patient as a candidate for further CRC screening and/or CRC treatment therapy.

摘要翻译： 提供了通过检测来自受试者的样品中CRC的至少三种生物标志物的存在和/或量来诊断高风险腺瘤或结肠直肠癌的方法。 所述方法和生物标志物可用于为患有CRC或处于患CRC的风险的患者或准确诊断患CRC或具有CRC风险的受试者开发准确的预后。 方法和生物标志物可以用于鉴定和/或分类患者作为进一步的CRC筛选和/或CRC治疗疗法的候选者。

公开(公告)号：EP3183578B1

公开(公告)日：2020-06-03

申请号：EP15757396.5

申请日：2015-08-21

申请人： Abbott Laboratories ,  Hvidovre Hospital ,  University of Copenhagen

发明人： DAVIS, Gerard J. ,  GAWEL, Susan H. ,  YANG, Xiaoqing ,  NIELSEN, Hans Jørgen ,  CHRISTENSEN, Ib Jarle

IPC分类号： A61N5/10 ,  G01N33/574 ,  C12Q1/68

摘要： Provided are methods of diagnosing high risk adenomas or colorectal cancer by detecting the presence and/or amount of at least three biomarkers of CRC in a sample from a subject. The methods and biomarkers may be used to develop an accurate prognosis for a patient having CRC or at risk of having CRC or accurately diagnose a subject having or at risk of having CRC. The methods and biomarkers may be used to identify and/or classify a patient as a candidate for further CRC screening and/or CRC treatment therapy.

公开(公告)号：EP3183578B8

公开(公告)日：2020-07-15

申请号：EP15757396.5

申请日：2015-08-21

申请人： Abbott Laboratories ,  Hvidovre Hospital ,  University of Copenhagen ,  Rigshospitalet

发明人： DAVIS, Gerard J. ,  GAWEL, Susan H. ,  YANG, Xiaoqing ,  NIELSEN, Hans Jørgen ,  CHRISTENSEN, Ib Jarle

IPC分类号： A61N5/10 ,  G01N33/574 ,  C12Q1/68

公开(公告)号：EP2344886A1

公开(公告)日：2011-07-20

申请号：EP09736115.8

申请日：2009-09-14

申请人： Herlev Hospital ,  Rigshospitalet ,  Hvidovre Hospital

发明人： JOHANSEN, Julia Sidenius ,  BOJESEN, Stig ,  NORDESTGAARD, Børge Grønne ,  NIELSEN, Hans Jørgen ,  CHRISTENSEN, Ib Jarle

IPC分类号： G01N33/53 ,  G01N33/58 ,  G01N33/68 ,  G01N33/574

CPC分类号： G01N33/6887 ,  G01N33/57419 ,  G01N33/57488 ,  G01N2800/52

摘要： The present invention relates to a methods for selecting a treatment for a specific disease or disorder, together with a method of monitoring therapeutic treatment of a specific disease or disorder and a method of determining a prognosis for a subject before, during and after administering a treatment by determining the level of YKL-40 in a sample obtained from the subject and comparing said level with one or more reference levels of YKL-40. The reference level is typically a level obtained from healthy individuals or a level previously obtained from the same subject. The present invention further relates to a kit and a device that may be used in the methods of the present invention.