公开(公告)号：EP1951725B1

公开(公告)日：2010-11-03

申请号：EP06829983.3

申请日：2006-11-14

申请人： Abbott Products GmbH

发明人： ANTEL, Jochen ,  WALDECK, Harald ,  SCHOEN, Uwe ,  GREGORY, Peter-Colin ,  WURL, Michael ,  FIRNGES, Michael ,  REICHE, Dania ,  REINECKER, Uwe ,  SANN, Holger

IPC分类号： C07D491/10 ,  C07D491/20 ,  A61K31/438 ,  A61P27/06 ,  A61P25/00 ,  A61P3/00 ,  A61P35/00

CPC分类号： C07D491/10

摘要： The present invention relates to novel N-sulfamoyl-N'-benzopyranpiperidines of general formula (I) and their physiologically acceptable acid addition salts, to pharmaceutical compositions comprising them, processes for their preparation, and their use for the prophylaxis and/or treatment and/or prevention and/or inhibition of glaucoma, epilepsy, bipolar disorders, migraine, neuropathic pain, obesity, type II diabetes, metabolic syndrome, alcohol dependence, and/or cancer, and its concomitant and/or secondary diseases or conditions.

公开(公告)号：EP1954678B1

公开(公告)日：2012-03-21

申请号：EP06830200.9

申请日：2006-11-30

申请人： Abbott Products GmbH

发明人： JASSERAND, Daniel ,  SCHOEN, Uwe ,  ANTEL, Jochen ,  FIRNGES, Michael ,  REICHE, Dania ,  SANN, Holger ,  BRÜCKNER, Reinhard

IPC分类号： C07D213/38 ,  C07D295/12 ,  C07D307/52 ,  C07D307/81 ,  C07D317/58 ,  C07D333/20 ,  C07D333/28 ,  C07D333/58 ,  C07D407/06 ,  C07D409/06 ,  A61K31/4965 ,  A61K31/497 ,  A61P1/00

CPC分类号： C07D295/13 ,  C07D213/38 ,  C07D295/125 ,  C07D307/52 ,  C07D307/81 ,  C07D317/58 ,  C07D333/20 ,  C07D333/28 ,  C07D333/58 ,  C07D407/06 ,  C07D409/06

摘要： The present invention relates to novel 3-cyano-naphthalene-1-carboxylic acid perhydroxyalkylmethyl-piperazine compounds of formula I which are antagonistic to tachykinin receptors. The present invention is further directed to pharmaceutical compositions comprising such compounds, to processes for the preparation of such compounds and to intermediate products of these processes.

公开(公告)号：EP1751126B1

公开(公告)日：2010-09-01

申请号：EP05716736.3

申请日：2005-02-18

申请人： Abbott Products GmbH

发明人： WALDECK, Harald ,  ANTEL, Jochen ,  EYTING, Sabine ,  WURL, Michael ,  GREGORY, Peter-Colin ,  WOLFF, Maike

IPC分类号： C07D305/12 ,  A61K31/335 ,  A61P3/00

CPC分类号： C07D305/12

摘要： The invention relates to substituted β-lactones (oxetanones) of general formula (I), in which R1, R2 and n have the meanings cited in the description, and to medicaments, which contain these compounds and which have a pancreas lipase-inhibiting effect. The invention also relates to a method for producing the compounds of formula (I) and to intermediate products of this method.

公开(公告)号：EP2207766A1

公开(公告)日：2010-07-21

申请号：EP08838679.2

申请日：2008-10-17

申请人： Abbott Products GmbH

发明人： SCHOEN, Uwe ,  WALDECK, Harald ,  REINECKER, Uwe ,  GREGORY, Peter-Colin ,  REICHE, Dania ,  SANN, Holger ,  WURL, Michael ,  ANTEL, Jochen

IPC分类号： C07C307/02 ,  A61K31/095 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07C307/02 ,  C07C2602/42

摘要： This invention relates to sulfamates of Formula (I), wherein R1 to R3 and n are defined in the claims, having carbonic anhydrase enzyme inhibitory activity, to medicaments comprising these compounds, to pharmaceutical compositions comprising these compounds, and to processes for the preparation of these compounds. The invention is also directed to the use of such compounds, medicaments and compositions, particularly to their use in administering them to patients to achieve a therapeutic effect.

摘要翻译： 本发明涉及式（I）的氨基磺酸盐，其中R1至R3和n在权利要求书中具有碳酸酐酶抑制活性，包含这些化合物的药物，包含这些化合物的药物组合物，以及制备 这些化合物。 本发明还涉及这些化合物，药物和组合物的用途，特别是其用于将它们施用于患者以达到治疗效果的用途。