公开(公告)号：EP1466177A2

公开(公告)日：2004-10-13

申请号：EP02789983.0

申请日：2002-12-02

申请人： Abgenix, Inc.

发明人： WALKER, Wynn, L. ,  JIA, Xiao-Chi ,  GALLO, Michael ,  KANG, Jaspal, Singh ,  BABCOOK, John ,  DAVIS, Geoff ,  GREEN, Larry ,  JOHO, Keith

IPC分类号： G01N33/53

CPC分类号： C40B30/04 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/68 ,  G01N33/6845 ,  G01N2500/04

摘要： Methods to screen antibodies against an antigen, categorize them according to the epitope they recognize, and rank them according to their binding affinities, thereby providing a method to rapidly and efficiently identify antibodies having potential usefulness in therapeutic products are described. Also described are methods of evaluating antibodies to determine their potential usefulness in therapeutic products.

公开(公告)号：EP1461423A2

公开(公告)日：2004-09-29

申请号：EP02804495.6

申请日：2002-12-02

申请人： Abgenix, Inc.

发明人： JIA, Xiao-Chi ,  GALLO, Michael ,  KANG, Jaspal, Singh ,  WALKER, Wynn, L. ,  JOHO, Keith

IPC分类号： C12N5/24 ,  C12N5/22 ,  C07K16/30

CPC分类号： G01N33/543 ,  G01N33/54306 ,  G01N33/58 ,  G01N33/6878 ,  G06F17/16 ,  G06F19/24

摘要： Methods for categorizing antibodies based on their epitope binding characteristics are described. Methods and systems for determining the epitope recognition properties of different antibodies are provided. Also provided are data analysis processes for clustering antibodies on the basis of their epitope recognition properties and for identifying antibodies having distinct epitope binding characteristics.