公开(公告)号：EP4350345A2

公开(公告)日：2024-04-10

申请号：EP23214392.5

申请日：2012-06-25

申请人： Ablynx N.V.

发明人： Baumeister, Judith ,  Bouche, Marie-Paule Lucienne Armanda ,  Boutton, Carlo ,  Buyse, Marie-Ange ,  Snoeck, Veerle ,  Staelens, Stephanie

IPC分类号： G01N33/00

摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; - methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; - modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have nor or a low(er)/reduced tendency to give rise to such protein interference or such a signal.

公开(公告)号：EP4350345A3

公开(公告)日：2024-07-24

申请号：EP23214392.5

申请日：2012-06-25

申请人： Ablynx N.V.

发明人： Baumeister, Judith ,  Bouche, Marie-Paule Lucienne Armanda ,  Boutton, Carlo ,  Buyse, Marie-Ange ,  Snoeck, Veerle ,  Staelens, Stephanie

IPC分类号： C07K16/00 ,  G01N33/00 ,  C07K16/28 ,  C07K16/42

CPC分类号： A61K2039/50520130101 ,  C07K16/00 ,  C07K16/2875 ,  C07K16/42 ,  C07K2317/2220130101 ,  C07K2317/3120130101 ,  C07K2317/3420130101 ,  C07K2317/3520130101 ,  C07K2317/56720130101 ,  C07K2317/56920130101 ,  C07K2317/9220130101 ,  G01N33/5306 ,  G01N33/54393 ,  G01N33/6857 ,  C07K16/08 ,  C12N5/0688

摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; - methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; - modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have nor or a low(er)/reduced tendency to give rise to such protein interference or such a signal.

公开(公告)号：EP2974737A1

公开(公告)日：2016-01-20

申请号：EP15179669.5

申请日：2012-06-25

申请人： Ablynx N.V.

发明人： Baumeister, Judith ,  Bouche, Marie-Paule Lucienne Armanda ,  Boutton, Carlo ,  Buyse, Marie-Ange ,  Snoeck, Veerle ,  Staelens, Stephanie

IPC分类号： A61K39/00 ,  C07K16/00 ,  C07K16/28 ,  C07K16/42 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68

CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/2875 ,  C07K16/42 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/92 ,  G01N33/5306 ,  G01N33/54393 ,  G01N33/6857

摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; - methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; - modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have nor or a low(er)/reduced tendency to give rise to such protein interference or such a signal.

摘要翻译： 本发明提供，并且在某些具体的，但非限制性的方面涉及：测定并可以用来预测是否如上述给定的ISV会受到蛋白的干扰和/或产生在（非特异性）信号在寻求 测定法（：如实施例中在ADA免疫测定法）。 搜索预测分析可以用来测试实例给定的ISV可能具有产生搜索蛋白干扰和/或寻求的信号的趋势; 选择ISV的不属于或不容易搜索蛋白干扰或给予寻求一个信号; 将（完全或部分）降低的倾向以产生干扰搜索或搜索，以测定或试验也可用于测试信号是否某些修饰在ISV; 和/或作为在测定或测试没有可用于指导修改或ISV的改进，以便降低其倾向以产生搜索蛋白干扰或信号; - 方法用于修改和/或改进的ISV为以去除或减少他们的倾向产生蛋白干扰搜索或搜索的信号; - 修改也可以在ISV引入并消除或减少其倾向产生蛋白干扰搜索或搜索信号; ISV的已特别选定的（例如，使用中所述的测定法（S））到没有或低（更低）/趋势降低产生蛋白干扰搜索或搜索的信号; 修改和/或改进ISV的有，也没有或低（更低）/减少倾向产生蛋白干扰搜索或搜索的信号。

公开(公告)号：EP4119944A1

公开(公告)日：2023-01-18

申请号：EP22178896.1

申请日：2017-06-21

申请人： Ablynx N.V.

发明人： Snoeck, Veerle ,  Bontinck, Lieselot ,  Poelmans, Sofie ,  Mortier, Kjell ,  Buyse, Marie-Ange ,  Dekeyzer, Lies ,  Baumeister, Judith

IPC分类号： G01N33/53

摘要： The present invention generally relates to improved pharmacokinetic assays for measuring levels of immunoglobulin single variable domains (also referred to herein as "ISVs" or "ISVDs") and of proteins and polypeptides that comprise at least one ISV (as further described herein) in biological samples.

公开(公告)号：EP3020728A1

公开(公告)日：2016-05-18

申请号：EP15196472.3

申请日：2012-06-25

申请人： Ablynx N.V.

发明人： Baumeister, Judith ,  Bouche, Marie-Paule Lucienne Armanda ,  Boutton, Carlo ,  Buyse, Marie-Ange ,  Snoeck, Veerle ,  Staelens, Stephanie

IPC分类号： C07K16/00 ,  C07K16/28 ,  C07K16/42 ,  G01N33/00

CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/2875 ,  C07K16/42 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/92 ,  G01N33/5306 ,  G01N33/54393 ,  G01N33/6857

摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; - methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; - modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have nor or a low(er)/reduced tendency to give rise to such protein interference or such a signal.

公开(公告)号：EP2944654A1

公开(公告)日：2015-11-18

申请号：EP15173573.5

申请日：2012-06-25

申请人： Ablynx N.V.

发明人： Baumeister, Judith ,  Bouche, Marie-Paule Lucienne Armanda ,  Boutton, Carlo ,  Buyse, Marie-Ange ,  Snoeck, Veerle ,  Staelens, Stephanie

IPC分类号： C07K16/00 ,  C07K16/28 ,  C07K16/42 ,  G01N33/00

CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/2875 ,  C07K16/42 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/92 ,  G01N33/5306 ,  G01N33/54393 ,  G01N33/6857

摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; - methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; - modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have nor or a low(er)/reduced tendency to give rise to such protein interference or such a signal.

公开(公告)号：EP2944653A1

公开(公告)日：2015-11-18

申请号：EP15173572.7

申请日：2012-06-25

申请人： Ablynx N.V.

发明人： Baumeister, Judith ,  Bouche, Marie-Paule Lucienne Armanda ,  Boutton, Carlo ,  Buyse, Marie-Ange ,  Snoeck, Veerle ,  Staelens, Stephanie

IPC分类号： C07K16/00 ,  G01N33/00 ,  C07K16/28 ,  C07K16/42

CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K16/2875 ,  C07K16/42 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/92 ,  G01N33/5306 ,  G01N33/54393 ,  G01N33/6857

摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; - methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; - modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have nor or a low(er)/reduced tendency to give rise to such protein interference or such a signal.

摘要翻译： 本发明提供，并且在某些具体但非限制性的方面涉及：可用于预测给定的ISV是否将如本文所述受到蛋白质干扰和/或在这种情况下产生（特异性）信号的测定 测定（例如在ADA免疫测定中）。 这种预测分析可以例如用于测试给定的ISV是否具有引起这种蛋白质干扰和/或这种信号的倾向; 选择不易或不易受这种蛋白质干扰或产生这种信号的ISV; 作为可用于测试ISV的某些修改是否（全部或部分）降低其引起此类干扰或此类信号倾向的测定或测试; 和/或作为可用于指导ISV的修饰或改进从而降低其引起此类蛋白质干扰或信号倾向的测定或测试; - 修改和/或改进ISV以去除或减少它们引起这种蛋白质干扰或这样的信号的倾向的方法; - 可引入ISV的修改，以消除或降低其引起此类蛋白质干扰或此类信号的倾向; 已经特别选择（例如，使用本文所述的测定法）的ISV具有不引起这种蛋白质干扰或这种信号的倾向或低（er）/降低的倾向; 修饰的和/或改进的ISV，其具有或不具有或具有低（er）/降低的倾向以引起这种蛋白质干扰或这样的信号。