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2.发明公开
公开(公告)号：EP4374916A2
公开(公告)日：2024-05-29
申请号：EP23219513.1
申请日：2016-03-30
申请人： MedImmune Limited
发明人： COHEN, Emma, S , LOWE, David, C , BUTLER, Robin , SCOTT, Ian, C , VOUSDEN, Katherine, A , STRAIN, Martin, D , CARMEN, Sara , ENGLAND, Elizabeth, H , KEMP, Benjamin, P , REES, David, G , OVERED-SAYER, Catherine, L , MUSTELIN, Tomas, M , SLEEMAN, Matthew , HOUSLAY, Kirsty
IPC分类号： A61P11/06
CPC分类号： C07K14/54 , C07K16/244 , A61K2039/50520130101 , C07K2317/2120130101 , C07K2317/3320130101 , C07K2317/3420130101 , C07K2317/56520130101 , C07K2317/56720130101 , C07K2317/62220130101 , C07K2317/7620130101 , C07K2317/9220130101 , C07K2319/3020130101 , A01K67/0278 , A01K2217/07220130101 , A01K2227/10520130101 , A01K2267/0320130101 , A61P11/06
摘要： The present invention provides isolated IL-33 proteins, active fragments thereof and antibodies, antigen binding fragments thereof, against IL-33 proteins. Also provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders.
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3.发明公开
公开(公告)号：EP4396227A1
公开(公告)日：2024-07-10
申请号：EP22776885.0
申请日：2022-09-02
IPC分类号： C07K16/24 , C07K16/44 , C07K16/46 , A61K39/395 , A61K31/00 , A61P37/06 , A61P35/00 , A61P13/12 , A61K49/00 , A61K51/04
CPC分类号： A61K2039/50520130101 , A61K39/39558 , A61P37/06 , A61P35/00 , A61P13/12 , C07K16/44 , C07K16/24 , C07K2317/3120130101 , C07K2317/3320130101 , C07K2317/5220130101 , C07K2317/5520130101 , C07K2317/56520130101 , C07K2317/56720130101 , C07K2317/6420130101 , C07K2317/62220130101 , C07K2317/7120130101 , C07K2317/9220130101 , C07K2317/9020130101 , C07K2319/0020130101 , C07K2317/7020130101 , C07K2317/9420130101 , A61K51/088 , A61K47/6879 , A61K47/6845 , A61K45/06
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4.发明公开
公开(公告)号：EP4328245A3
公开(公告)日：2024-06-05
申请号：EP23207654.7
申请日：2014-12-18
申请人： Kymab Ltd.
发明人： CLUBE, Jasper
IPC分类号： C07K16/40 , A61K31/7105 , A61K31/713
CPC分类号： C07K16/40 , C12N9/6424 , C07K2317/2120130101 , C07K2317/56720130101 , C07K2317/9220130101
摘要： The invention relates to human targets of interest (TOI), anti-TOI ligands, kits compositions and method.
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公开(公告)号：EP4321219A3
公开(公告)日：2024-05-15
申请号：EP23209620.6
申请日：2017-12-18
申请人： Medimmune Limited , Fundació Privada Institució Catalana de Recerca I Estudis Avançats , Fundació Privada Institut d'Investigació Oncològica de Vall Hebron
发明人： SEOANE SUAREZ, Joan , ANIDO FOLGUEIRA, Judit , FRANSSON, Johan , JULIEN, Jean-philippe , RAMAN, Swetha
IPC分类号： C07K16/24 , A61K39/395 , A61P35/00
CPC分类号： A61K2039/50520130101 , A61P35/00 , A61P35/02 , C07K16/244 , C07K2299/0020130101 , C07K2317/2420130101 , C07K2317/3320130101 , C07K2317/3420130101 , C07K2317/56720130101 , C07K2317/7620130101 , C07K2317/9220130101
摘要： Described herein are antibodies that target Leukemia Inhibitory Factor (LIF). Also described herein are uses of these antibodies for the treatment of cancer.
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7.发明公开
公开(公告)号：EP4374916A3
公开(公告)日：2024-08-28
申请号：EP23219513.1
申请日：2016-03-30
申请人： MedImmune Limited
发明人： COHEN, Emma, S , LOWE, David, C , BUTLER, Robin , SCOTT, Ian, C , VOUSDEN, Katherine, A , STRAIN, Martin, D , CARMEN, Sara , ENGLAND, Elizabeth, H , KEMP, Benjamin, P , REES, David, G , OVERED-SAYER, Catherine, L , MUSTELIN, Tomas, M , SLEEMAN, Matthew , HOUSLAY, Kirsty
IPC分类号： C07K16/24 , A61K39/395 , A61K39/00 , A01K67/027 , C07K14/54 , C07K14/715 , A61P11/06 , A01K67/0278
CPC分类号： C07K14/54 , C07K16/244 , A61K2039/50520130101 , C07K2317/2120130101 , C07K2317/3320130101 , C07K2317/3420130101 , C07K2317/56520130101 , C07K2317/56720130101 , C07K2317/62220130101 , C07K2317/7620130101 , C07K2317/9220130101 , C07K2319/3020130101 , A01K67/0278 , A01K2217/07220130101 , A01K2227/10520130101 , A01K2267/0320130101 , A61P11/06
摘要： The present invention provides isolated IL-33 proteins, active fragments thereof and antibodies, antigen binding fragments thereof, against IL-33 proteins. Also provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders.
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公开(公告)号：EP3722310B1
公开(公告)日：2024-08-28
申请号：EP20158159.2
申请日：2009-06-25
IPC分类号： C07K16/22 , A61K39/395
CPC分类号： C07K2317/2420130101 , C07K2317/56520130101 , C07K2317/56720130101 , C07K2317/62220130101 , C07K2317/7320130101 , C07K2317/9220130101 , C07K16/22 , A61P15/00 , A61P15/08 , A61P17/06 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P33/14 , A61P35/00 , A61P37/00 , A61P43/00 , A61P7/10 , A61P9/10
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9.发明公开
公开(公告)号：EP4402165A1
公开(公告)日：2024-07-24
申请号：EP22782640.1
申请日：2022-09-09
发明人： FU, Ying , FLEMING, Bryan, D. , RENN, Alex , HALL, Matthew, D. , SIMEONOV, Anton
IPC分类号： C07K16/10
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公开(公告)号：EP4350345A3
公开(公告)日：2024-07-24
申请号：EP23214392.5
申请日：2012-06-25
申请人： Ablynx N.V.
发明人： Baumeister, Judith , Bouche, Marie-Paule Lucienne Armanda , Boutton, Carlo , Buyse, Marie-Ange , Snoeck, Veerle , Staelens, Stephanie
CPC分类号： A61K2039/50520130101 , C07K16/00 , C07K16/2875 , C07K16/42 , C07K2317/2220130101 , C07K2317/3120130101 , C07K2317/3420130101 , C07K2317/3520130101 , C07K2317/56720130101 , C07K2317/56920130101 , C07K2317/9220130101 , G01N33/5306 , G01N33/54393 , G01N33/6857 , C07K16/08 , C12N5/0688
摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; - methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; - modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have nor or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
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