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公开(公告)号：EP3332800A1
公开(公告)日：2018-06-13
申请号：EP18153676.4
申请日：2015-06-16
申请人： Ablynx NV
发明人： Duby, Christian
摘要： The present invention is based on the finding that administration of polypeptides comprising at least one Immunoglobulin single variable domains against vWF to human TTP patients provides a significant decrease in the time to response. The invention provides a polypeptide comprising at least one immunoglobulin single variable domain (ISVD) against von Willebrand Factor (vWF) for use in treating a vWF-related disease in a human in need thereof. The invention further relates to dosage unit forms, kits and medical uses for treating TTP.
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公开(公告)号：EP3335724A1
公开(公告)日：2018-06-20
申请号：EP18153674.9
申请日：2015-06-16
申请人： Ablynx NV
发明人： Duby, Christian
CPC分类号： C07K16/36 , A61K38/36 , A61K2039/505 , A61K2039/545 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76
摘要： The present invention is based on the finding that administration of polypeptides comprising at least one Immunoglobulin single variable domains against vWF to human TTP patients provides a significant decrease in the time to response. The invention provides a polypeptide comprising at least one immunoglobulin single variable domain (ISVD) against von Willebrand Factor (vWF) for use in treating a vWF-related disease in a human in need thereof. The invention further relates to dosage unit forms, kits and medical uses for treating TTP.
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公开(公告)号：EP4059513A1
公开(公告)日：2022-09-21
申请号：EP22172948.6
申请日：2015-06-16
申请人： Ablynx NV
发明人： Duby, Christian
摘要： The present invention is based on the finding that administration of polypeptides comprising at least one Immunoglobulin single variable domains against vWF to human TTP patients provides a significant decrease in the time to response. The invention provides a polypeptide comprising at least one immunoglobulin single variable domain (ISVD) against von Willebrand Factor (vWF) for use in treating a vWF-related disease in a human in need thereof. The invention further relates to dosage unit forms, kits and medical uses for treating TTP.
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公开(公告)号：EP3332800B1
公开(公告)日：2020-08-26
申请号：EP18153676.4
申请日：2015-06-16
申请人： Ablynx NV
发明人： Duby, Christian
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公开(公告)号：EP3335723A1
公开(公告)日：2018-06-20
申请号：EP18153673.1
申请日：2015-06-16
申请人： Ablynx NV
发明人： Duby, Christian
CPC分类号： C07K16/36 , A61K38/36 , A61K2039/505 , A61K2039/545 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76
摘要： The present invention is based on the finding that administration of polypeptides comprising at least one Immunoglobulin single variable domains against vWF to human TTP patients provides a significant decrease in the time to response. The invention provides a polypeptide comprising at least one immunoglobulin single variable domain (ISVD) against von Willebrand Factor (vWF) for use in treating a vWF-related disease in a human in need thereof. The invention further relates to dosage unit forms, kits and medical uses for treating TTP.
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