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公开(公告)号：EP3590950A1
公开(公告)日：2020-01-08
申请号：EP19177842.2
申请日：2012-05-09
申请人： Ablynx NV
发明人： Brigé, Ann , Schotte, Peter , Walcarius, Bart
摘要： Methods are provided for the expression of immunoglobulin variable domains that are secreted into the culture medium. The methods provide for the production of homogeneous immunoglobulin variable domains in which the proportion of product-related variants that comprise, at the N-terminus, at least one redundant amino acid residue derived from the secretion signal is strongly reduced or absent.
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公开(公告)号：EP3332800A1
公开(公告)日：2018-06-13
申请号：EP18153676.4
申请日：2015-06-16
申请人： Ablynx NV
发明人： Duby, Christian
摘要： The present invention is based on the finding that administration of polypeptides comprising at least one Immunoglobulin single variable domains against vWF to human TTP patients provides a significant decrease in the time to response. The invention provides a polypeptide comprising at least one immunoglobulin single variable domain (ISVD) against von Willebrand Factor (vWF) for use in treating a vWF-related disease in a human in need thereof. The invention further relates to dosage unit forms, kits and medical uses for treating TTP.
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公开(公告)号：EP3294319A1
公开(公告)日：2018-03-21
申请号：EP16722891
申请日：2016-05-13
申请人： ABLYNX NV
IPC分类号： A61K38/17 , A61K39/395 , C07K16/28
CPC分类号： C07K16/2809 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K16/2887 , C07K16/30 , C07K16/3007 , C07K16/32 , C07K2317/31 , C07K2317/569 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： T cell recruiting polypeptides are provided that bind CD3 on a T cell. The polypeptides can be used in methods for treatment of cancers.
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公开(公告)号：EP3279214A1
公开(公告)日：2018-02-07
申请号：EP17192342.8
申请日：2011-10-28
申请人： Ablynx NV
发明人： Brigé, Ann , Walcarius, Bart , Meyvis, Yves , Sergi, Mauro
CPC分类号： C07K16/18 , C07K16/00 , C07K16/28 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/569
摘要： The present disclosure relates to an improved method for the manufacture of immunoglobulin single variable domains. More specifically, the present disclosure relates to a method of producing immunoglobulin single variable domains in which the proportion of carbamylated variants is strongly reduced or absent and to improved immunoglobulin single variable domains obtainable by methods of the present disclosure.
摘要翻译： 本公开涉及用于制造免疫球蛋白单可变结构域的改进方法。 更具体地，本公开涉及产生免疫球蛋白单可变结构域的方法，其中氨基甲酰化变体的比例大大降低或不存在，并且涉及通过本公开的方法可获得的改善的免疫球蛋白单可变结构域。
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6.发明公开GENETIC IMMUNIZATION FOR PRODUCING IMMUNOGLOBULINS AGAINST CELL-ASSOCIATED ANTIGENS SUCH AS P2X7, CXCR7 OR CXCR4 审中-公开基因免疫用于生产免疫球蛋白针对细胞相关抗原AS P2X7，CXCR7或CXCR4
公开(公告)号：EP2370465A2
公开(公告)日：2011-10-05
申请号：EP09799348.9
申请日：2009-12-21
申请人： Ablynx NV
发明人： LAEREMANS, Toon , STORTELERS, Catelijne , NOLTE, Friedrich , GONZALEZ, Maria , ASSUNCAO, Joana , VAN ROMPAEY, Philippe
CPC分类号： C07K16/28 , A61K2039/505 , A61K2039/53 , C07K16/00 , C07K16/2866 , C07K2317/22 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to a method for generating immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored. The invention also provides immunoglobulin sequences obtainable by the method of the invention. Specifically, the present invention relates to the generation of immunoglobulin sequences by use of DNA vaccination. More specifically, the present invention relates to generation of immunoglobulin sequences in camelids, preferably directed against cell-associated antigens, in particular antigens with multiple transmembrane spanning domains, including GPCRs and ion channels, by DNA vaccination. Furthermore, the present invention relates to said immunoglobulin sequences against cell-associated antigens, more particularly, antigens that are membrane-anchored, such as e.g. GPCRs and ion channels, more preferably ion channels.
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公开(公告)号：EP4442708A2
公开(公告)日：2024-10-09
申请号：EP24191390.4
申请日：2018-01-17
申请人： Ablynx NV
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K2317/2220130101 , C07K2317/3020130101 , C07K2317/3320130101 , C07K2317/56920130101 , C07K2317/9220130101 , A61P43/00
摘要： The present invention relates to amino acid sequences that can bind to serum albumin.
In particular, the present invention relates to immunoglobulin single variable domains, and in particular heavy-chain immunoglobulin single variable domains, that can bind to serum albumin.
The invention also relates to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise at least one of the immunoglobulin single variable domains binding to serum albumin that are described herein.-
公开(公告)号：EP3630818A1
公开(公告)日：2020-04-08
申请号：EP18731372.1
申请日：2018-06-04
申请人： Ablynx NV , Merck Patent GmbH
发明人： STEFFENSEN, Soren , BESTE, Gerald , HERMANS, Guy , GÜHRING, Hans , LADEL, Christoph , TOLEIKIS, Lars
IPC分类号： C07K16/18 , C07K16/40 , C07K16/46 , A61K39/395 , A61P19/02
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9.发明公开
公开(公告)号：EP3512880A1
公开(公告)日：2019-07-24
申请号：EP17768771.2
申请日：2017-09-15
申请人： Ablynx NV , VIB VZW , Vrije Universiteit Brussel
发明人： VANLANDSCHOOT, Peter , CABRITO, Ines , STIJLEMANS, Benoît , SPARKES, Amanda , VAN GINDERACHTER, Jo , DE BAETSELIER, Patrick
IPC分类号： C07K16/18 , C07K16/24 , A61K39/395
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公开(公告)号：EP3511018A1
公开(公告)日：2019-07-17
申请号：EP19157147.0
申请日：2014-05-16
申请人： Ablynx NV
IPC分类号： A61K39/395 , A61K9/08
摘要： The present invention relates to stable formulations of polypeptides, e.g. immunoglobulin single variable domains, in particular immunoglobulin single variable domains directed against von Willebrand Factor (vWF).
The invention provides formulations which are stable upon storage for prolonged periods of time and over a broad range of temperatures. The formulations of the invention ensure a high stability of the polypeptide, allowing multiple freeze-thaw cycles without chemical or physical deterioration, and provide stability in relation to mechanical stress, such as shake, shear or stir stress. They are suitable for pharmaceutical and diagnostic preparations and compatible with pharmaceutically acceptable diluents.
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