专利检索 ap:("Academisch Ziekenhuis Leiden h.o.d.n. Leids Universitair Medisch Centrum") AND inv:"DIEHL, Linda" 第 1 页

1.

发明授权
INDUCTION OF ANTI-TUMOR CTL IMMUNITY THROUGH IN VIVO TRIGGERING OF 4-1BB AND/OR CD40 有权
标题翻译：抗肿瘤CTL免疫的THROUGH 4-1BB和/或CD40的激活体内诱导

公开(公告)号：EP1490407B1

公开(公告)日：2007-05-16

申请号：EP03745713.2

申请日：2003-04-04

申请人： Academisch Ziekenhuis Leiden h.o.d.n. Leids Universitair Medisch Centrum

发明人： DIEHL, Linda , VAN MIERLO, Geertje , MELIEF, Cornelis, J., M. , TOES, Rene , OFFRINGA, Rienk

IPC分类号： C07K16/28 , A61K39/395 , C07K14/025 , A61K39/12

CPC分类号： C07K16/2878 , A61K2039/505

摘要： Disclosed is a method and composition for treating tumors or infectious diseases, wherein the composition comprises an agonistic anti-CD40 antibody or a fragment thereof, and/or an agonistic anti-4-1BB antibody or a fragment thereof. The agonistic antibody molecules include fragments like Fab, (Fab')2 and Fv. The methods and compositions may further comprise polypeptides or mucleic acid sequences having or encoding a class 1 MHC or class II MHC-restricted T cell epitope.