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公开(公告)号：EP2278960B2
公开(公告)日：2019-11-13
申请号：EP09721703.8
申请日：2009-03-12
IPC分类号： A61K31/00 , A61K31/426 , A61P9/06
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公开(公告)号：EP2278960B1
公开(公告)日：2016-11-30
申请号：EP09721703.8
申请日：2009-03-12
IPC分类号： A61K31/00 , A61K31/426 , A61P9/06
摘要： The present invention relates to a dosing regimen for a selective S1P1 receptor agonist, whereby the selective S1P1 receptor agonist is administered to a subject in such a way that during the initial treatment phase the selective S1P1 receptor agonist is administered at a dose which induces desensitization of the heart wherein said dose is below the target dose, and at a dosing frequency that sustains desensitization of the heart, until no further acute heart rate reduction occurs, followed by dose up-titration to the target dose of the selective S1P1 receptor agonist.
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公开(公告)号：EP2278960A1
公开(公告)日：2011-02-02
申请号：EP09721703.8
申请日：2009-03-12
IPC分类号： A61K31/00 , A61K31/426
摘要： The present invention relates to a dosing regimen for a selective S1P1 receptor agonist, whereby the selective S1P1 receptor agonist is administered to a subject in such a way that during the initial treatment phase the selective S1P1 receptor agonist is administered at a dose which induces desensitization of the heart wherein said dose is below the target dose, and at a dosing frequency that sustains desensitization of the heart, until no further acute heart rate reduction occurs, followed by dose up-titration to the target dose of the selective S1P1 receptor agonist.
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