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1.发明授权TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE 有权三环咪唑化合物作为TRYPTOPHAN HYDROXYLASE的抑制剂
公开(公告)号：EP3071567B1
公开(公告)日：2017-09-06
申请号：EP14799475.0
申请日：2014-11-18
发明人： BUR, Daniel , GRISOSTOMI, Corinna , NAYLER, Oliver , REMEN, Lubos , VERCAUTEREN, Magali , WELFORD, Richard
IPC分类号： C07D471/04 , C07D471/14 , C07D498/12 , C07D513/14 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61P11/00 , A61P19/10 , A61P35/00 , A61P1/00 , A61P3/10 , A61P9/12 , A61P25/00
CPC分类号： C07D471/14 , C07D471/04 , C07D498/12 , C07D513/14
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公开(公告)号：EP3071578A1
公开(公告)日：2016-09-28
申请号：EP14799473.5
申请日：2014-11-18
发明人： BUR, Daniel , GRISOSTOMI, Corinna , NAYLER, Oliver , REMEN, Lubos , VERCAUTEREN, Magali , WELFORD, Richard
IPC分类号： C07D513/14 , A61K31/437 , A61P11/06
CPC分类号： C07D513/14
摘要： wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.
摘要翻译： 其中R，R 1a，R 1b，R 2，R 3和X如本说明书所述，其制备方法，其药学上可接受的盐及其作为药物的用途，含有一种或多种式（I）化合物的药物组合物， ，用于制备式（I）化合物的方法，特别是其用作TPH调节剂。
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公开(公告)号：EP1863787A1
公开(公告)日：2007-12-12
申请号：EP06727679.0
申请日：2006-03-20
发明人： BOLLI, Martin , LEHMANN, David , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , VELKER, Jörg , WELLER, Thomas
IPC分类号： C07D333/72 , C07D333/78 , C07D413/04 , C07D409/12 , C07D413/14 , A61K31/38 , A61K31/41 , A61P37/00
CPC分类号： C07D409/12 , C07D333/72 , C07D333/78 , C07D413/04 , C07D413/14
摘要： The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
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公开(公告)号：EP2665720A1
公开(公告)日：2013-11-27
申请号：EP12704125.9
申请日：2012-01-18
发明人： BOLLI, Martin , LESCOP, Cyrille , MATHYS, Boris , MORRISON, Keith , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat
IPC分类号： C07D413/04 , A61K31/4439 , A61P37/00
CPC分类号： C07D413/14 , C07D413/04
摘要： The invention relates to pyridine derivatives of Formula (I) wherein A, R
1 , R
2 , R
3 , and R
4 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.-
公开(公告)号：EP2222667B1
公开(公告)日：2013-02-20
申请号：EP08859227.4
申请日：2008-12-09
发明人： BOLLI, Martin , LESCOP, Cyrille , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat
IPC分类号： C07D413/04 , C07D413/14 , A61K31/4245 , A61P37/02 , A61P37/06
CPC分类号： C07D413/04 , C07D413/14
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公开(公告)号：EP2262800A1
公开(公告)日：2010-12-22
申请号：EP09717044.3
申请日：2009-03-03
发明人： BOLLI, Martin , LESCOP, Cyrille , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat
IPC分类号： C07D413/14 , C07D417/14 , A61K31/506 , A61P37/00
CPC分类号： C07D413/14 , C07D417/14
摘要： The invention relates to novel pyrimidine-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Formula I.
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公开(公告)号：EP2262799A1
公开(公告)日：2010-12-22
申请号：EP09718458.4
申请日：2009-03-03
发明人： BOLLI, Martin , LESCOP, Cyrille , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat
IPC分类号： C07D413/04 , A61K31/4427 , A61P37/00
CPC分类号： C07D413/04
摘要： The invention relates to pyridine compounds, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
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公开(公告)号：EP2217594A2
公开(公告)日：2010-08-18
申请号：EP08846160.3
申请日：2008-10-31
发明人： BOLLI, Martin , LESCOP, Cyrille , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat
IPC分类号： C07D413/04 , C07D417/04 , A61K31/506 , A61P37/00
CPC分类号： C07D413/04 , C07D417/04
摘要： The invention relates to novel pyrimidine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents. Forumla (I) wherein A represents Formula (II), Formula (III), Formula (IV), Formula (V), Formula (VI), Formula (VII), Formula (VIII) or Formula (IX)
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公开(公告)号：EP2125797A1
公开(公告)日：2009-12-02
申请号：EP08719519.4
申请日：2008-02-29
发明人： BOLLI, Martin , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat , VELKER, Jörg
IPC分类号： C07D413/04 , C07D417/04 , A61K31/4439 , A61P37/00
CPC分类号： C07D417/04 , C07D417/14
摘要： The invention relates to novel amino-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
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公开(公告)号：EP2069335A1
公开(公告)日：2009-06-17
申请号：EP07826286.2
申请日：2007-09-06
发明人： BOLLI, Martin , LEHMANN, David , MATHYS, Boris , MUELLER, Claus , NAYLER, Oliver , STEINER, Beat , VELKER, Jörg
IPC分类号： C07D413/04 , C07D417/04 , A61K31/4439 , A61P37/00 , A61P19/00 , A61P35/00 , A61P9/00
CPC分类号： C07D413/04 , C07D417/04
摘要： The invention relates to pyridin-3-yl derivatives of Formula (I) wherein R1, R2, R3, R4, R5; R6 and A are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
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