公开(公告)号：EP1562986A2

公开(公告)日：2005-08-17

申请号：EP03775019.7

申请日：2003-11-14

申请人： Adherex Technologies, Inc.

发明人： BLASCHUK, Orest, W. ,  MICHAUD, Stephanie, Denise

IPC分类号： C07K14/705 ,  C07K7/04 ,  C07K7/64 ,  C07K16/28 ,  C07D211/58 ,  A61K38/00 ,  A61K39/00 ,  G01N33/50

CPC分类号： C07K5/1021 ,  A61K38/00 ,  C07D211/58 ,  C07K5/101 ,  C07K5/1013 ,  C07K5/1024 ,  C07K14/705

摘要： Modulating agents and methods for enhancing or inhibiting classical cadherin-mediated functions are provided. The modulating agents comprise at least a tryptophan-containing cell adhesion recognition sequence of a classical cadherin molecule, a conservative analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and/or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, pharmaceutically active substance and/or support material.