公开(公告)号：EP1560850A2

公开(公告)日：2005-08-10

申请号：EP03796218.0

申请日：2003-11-14

申请人： Adherex Technologies, Inc.

发明人： BLASCHUK, Orest, W. ,  MICHAUD, Stephanie, D.

IPC分类号： C07K14/705 ,  C07K7/06 ,  C07K16/28 ,  G01N33/50 ,  A61K38/17 ,  A61K38/08 ,  A61K39/395 ,  A61P35/00 ,  A61P37/00

CPC分类号： G01N33/5011 ,  A61K9/0009 ,  A61K9/7023 ,  A61K38/00 ,  C07K14/705 ,  C07K16/2896 ,  G01N33/5008 ,  G01N33/5026 ,  G01N33/6803 ,  G01N33/6842

摘要： Modulating agents and methods for enhancing or inhibiting nonclassical cadherin-mediated functions, such as atypical or desmosomal cadherin -mediated functions, are provided. The modulating agents comprise at least a tryptophan-containing cell adhesion recognition sequence of an atypical and/or desmosomal cadherin, a conservative analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and/or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, pharmaceutically active substance and/or support material.

公开(公告)号：EP1651672A2

公开(公告)日：2006-05-03

申请号：EP04779873.1

申请日：2004-07-30

申请人： Adherex Technologies, Inc.

发明人： BLASCHUK, Orest, W. ,  GOUR, Barbara, J. ,  FAROOKHI, Riaz ,  ALI, Anmar

IPC分类号： C07K14/705 ,  A61K38/17 ,  C07K7/64 ,  A61M25/00

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/56 ,  C07K7/64 ,  C07K14/705

摘要： Cyclic peptides comprising a cadherin cell adhesion recognition sequence HAV, and compositions comprising such cyclic peptides, are provided. Methods for using such peptides for modulating cadherin-mediated cell adhesion in a variety of contexts are also provided.

公开(公告)号：EP1366076A2

公开(公告)日：2003-12-03

申请号：EP01951873.7

申请日：2001-03-27

申请人： Adherex Technologies, Inc.

发明人： BLASCHUK, Orest, W. ,  SYMONDS, James, Matthew ,  GOUR, Barbara, J.

IPC分类号： C07K14/705

CPC分类号： C07K5/0808 ,  A61K38/00 ,  C07K5/1008 ,  C07K5/101 ,  C07K7/06 ,  C07K14/705 ,  C07K2319/00 ,  Y10S977/805

摘要： Modulating agents for inhibiting or enhancing desmosomal cadherin mediated cell adhesion are provided. The modulating agents comprise one or more of: a) a peptide sequence that is at least 50% identical to a desmosomal cadherin CAR sequence; b) a non-peptide mimetic of a desmosomal cadherin CAR sequence; c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds a desmosomal cadherin CAR sequence; and/or d) a polynucleotide encoding a polypeptide that comprises a desmosomal cadherin CAR sequence or analogue thereof. Methods for using such modulating agents for modulating desmosomal cadherin-mediated cell adhesion in a variety of contexts are also provided.

公开(公告)号：EP1562986A2

公开(公告)日：2005-08-17

申请号：EP03775019.7

申请日：2003-11-14

申请人： Adherex Technologies, Inc.

发明人： BLASCHUK, Orest, W. ,  MICHAUD, Stephanie, Denise

IPC分类号： C07K14/705 ,  C07K7/04 ,  C07K7/64 ,  C07K16/28 ,  C07D211/58 ,  A61K38/00 ,  A61K39/00 ,  G01N33/50

CPC分类号： C07K5/1021 ,  A61K38/00 ,  C07D211/58 ,  C07K5/101 ,  C07K5/1013 ,  C07K5/1024 ,  C07K14/705

摘要： Modulating agents and methods for enhancing or inhibiting classical cadherin-mediated functions are provided. The modulating agents comprise at least a tryptophan-containing cell adhesion recognition sequence of a classical cadherin molecule, a conservative analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and/or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, pharmaceutically active substance and/or support material.

公开(公告)号：EP1097168A2

公开(公告)日：2001-05-09

申请号：EP99928963.0

申请日：1999-07-12

申请人： Adherex Technologies, Inc.

发明人： DOHERTY, Patrick ,  BLASCHUK, Orest, W. ,  GOUR, Barbara, J.

IPC分类号： C07K14/705 ,  C07K7/06 ,  C07K7/64 ,  A61K47/48 ,  G01N33/68

CPC分类号： C07K7/06 ,  A61K38/12 ,  C07K7/64 ,  C07K14/705

摘要： Modulating agents and methods for enhancing or inhibiting cadherin-mediated functions are provided. The modulating agents comprise at least an HAV binding motif, an analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a motif. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and/or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, drug and/or support material.