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1.发明公开STABLE AND STERILE TISSUE ADHESIVE COMPOSITION WITH A CONTROLLED HIGH VISCOSITY 有权稳定和不育与控制的高粘度纤维胶成分
公开(公告)号：EP2303342A2
公开(公告)日：2011-04-06
申请号：EP09767897.3
申请日：2009-06-22
发明人： RUIZ, Rafael , ZHANG, Sheng
CPC分类号： A61L24/001 , A61L24/06 , C08L35/04
摘要： A stable and sterile adhesive composition with a controlled level of high viscosity is disclosed in the present invention. Adhesive compositions with different ranges of viscosity could be prepared by heating the adhesive monomer composition at mild temperature in the presence of pluronic polymer. The viscosity of the adhesive composition is able to be controlled to any desired level. A method of stabilizing the adhesive composition with a desired level of high viscosity is provided by using the combination of free radical and acid stabilizers. Methods for packaging, sterilizing and applying the adhesive in the medical field are also provided.
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2.发明授权
公开(公告)号：EP2603552B1
公开(公告)日：2017-05-17
申请号：EP11816926.7
申请日：2011-08-09
发明人： ZHANG, Sheng , RUIZ, Rafael, Sr.
CPC分类号： A61L26/0066 , A61K31/4166 , A61K31/785 , A61L24/0015 , A61L24/0021 , A61L24/02 , A61L24/06 , A61L26/0004 , A61L26/0014 , A61L26/0071 , A61L2300/404 , A61L2300/412 , C08F22/32 , C08L35/04
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3.发明授权METHOD OF PREPARING ADHESIVE COMPOSITIONS FOR MEDICAL USE: SINGLE ADDITIVE AS BOTH THE THICKENING AGENT AND THE ACCELERATOR 有权用于生产粘合剂组合物用于医疗应用：单剂作为增稠剂和油门
公开(公告)号：EP2303343B1
公开(公告)日：2016-01-13
申请号：EP09767901.3
申请日：2009-06-22
发明人： ZHANG, Sheng , RUIZ, Rafael
IPC分类号： A61L24/06 , C09J4/00 , A61K47/10 , A61K47/32 , A61K31/785
CPC分类号： A61L24/043 , A61K31/785 , A61K47/10 , A61K47/32 , A61L24/06 , C08L35/04
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公开(公告)号：EP2773566A2
公开(公告)日：2014-09-10
申请号：EP12846036.7
申请日：2012-11-01
发明人： RUIZ, Rafael, Sr. , ZHANG, Sheng , KRAUSS, Martin
IPC分类号： B65D25/40
CPC分类号： A61B17/00491 , A46B11/0075 , A61B2090/0813 , A61M35/003 , A61M35/006 , B05C17/00586 , B65D35/36 , B65D51/225
摘要： Applicators for storing, sterilizing, and dispensing adhesives. The applicators comprise a porous tip, a body, and a container containing a polymerizable cyanoacrylate monomer adhesive. The applicators are sterilized by radiation, and following sterilization, the adhesive remains substantially unpolymerized for about twenty four months.
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5.发明公开METHOD OF PREPARING ADHESIVE COMPOSITIONS FOR MEDICAL USE: SINGLE ADDITIVE AS BOTH THE THICKENING AGENT AND THE ACCELERATOR 有权用于生产粘合剂组合物用于医疗应用：单剂作为增稠剂和油门
公开(公告)号：EP2303343A2
公开(公告)日：2011-04-06
申请号：EP09767901.3
申请日：2009-06-22
发明人： ZHANG, Sheng , RUIZ, Rafael
CPC分类号： A61L24/043 , A61K31/785 , A61K47/10 , A61K47/32 , A61L24/06 , C08L35/04
摘要： The present invention relates to compositions of cyanoacrylate monomer, a method of improving the viscosity and/or the curing speed with a single additive and a process of providing sterilized cyanoacrylate adhesive compositions for application in the medical field.
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公开(公告)号：EP3580139A1
公开(公告)日：2019-12-18
申请号：EP18705258.4
申请日：2018-01-30
发明人： ZHANG, Sheng , RUIZ, Rafael , GUIDO, Amanda
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7.发明公开WOUND HEALING COMPOSITIONS BASED ON CYANOACRYLATES AND 5,5-DISUBSTITUTEDHYDANTOINS, INCLUDING PHENYTOIN 有权基于氰基丙烯酸酯的5,5-二取代乙内酰脲包括苯妥因伤口愈合组合物
公开(公告)号：EP2603552A1
公开(公告)日：2013-06-19
申请号：EP11816926.7
申请日：2011-08-09
发明人： ZHANG, Sheng , RUIZ, Rafael, Sr.
IPC分类号： C08K5/05
CPC分类号： A61L26/0066 , A61K31/4166 , A61K31/785 , A61L24/0015 , A61L24/0021 , A61L24/02 , A61L24/06 , A61L26/0004 , A61L26/0014 , A61L26/0071 , A61L2300/404 , A61L2300/412 , C08F22/32 , C08L35/04
摘要： A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1, 1 -disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.
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公开(公告)号：EP4274628A1
公开(公告)日：2023-11-15
申请号：EP22703470.9
申请日：2022-01-06
发明人： ZHANG, Sheng , GUIDO, Amanda
IPC分类号： A61L29/04
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公开(公告)号：EP2618741B1
公开(公告)日：2018-04-04
申请号：EP11761761.3
申请日：2011-09-15
发明人： RUIZ, Rafael, Sr. , ZHANG, Sheng , KRAUSS, Martin
IPC分类号： A61B17/00
CPC分类号： A61B17/00491
摘要： An applicator device for storing and dispensing an adhesive or sealant material, which are compatible with irradiation sterilization techniques, the applicator comprising: an applicator body comprising a cutting portion to break the frangible seal of the container for the adhesive, and a grasping and squeezing portion for controlling the flow rate of the adhesive; a container for an adhesive material that is movable relative to the applicator body and is made of materials with high barrier property; and a porous applicator tip that is secured to or frictionally fits into the applicator body.
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10.发明授权STABLE AND STERILE TISSUE ADHESIVE COMPOSITION WITH A CONTROLLED HIGH VISCOSITY 有权稳定和不育与控制的高粘度纤维胶成分
公开(公告)号：EP2303342B1
公开(公告)日：2015-04-01
申请号：EP09767897.3
申请日：2009-06-22
发明人： RUIZ, Rafael , ZHANG, Sheng
CPC分类号： A61L24/001 , A61L24/06 , C08L35/04
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