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22 条记录 (耗时 0.014 秒)

    STABLE AND STERILE TISSUE ADHESIVE COMPOSITION WITH A CONTROLLED HIGH VISCOSITY
    1.
    发明公开
    STABLE AND STERILE TISSUE ADHESIVE COMPOSITION WITH A CONTROLLED HIGH VISCOSITY 有权
    稳定和不育与控制的高粘度纤维胶成分

    公开(公告)号：EP2303342A2

    公开(公告)日：2011-04-06

    申请号：EP09767897.3

    申请日：2009-06-22

    申请人： Adhezion Biomedical, LLC

    发明人： RUIZ, Rafael ,  ZHANG, Sheng

    IPC分类号： A61L24/00 ,  A61L24/06 ,  C09J4/00

    CPC分类号： A61L24/001 ,  A61L24/06 ,  C08L35/04

    摘要： A stable and sterile adhesive composition with a controlled level of high viscosity is disclosed in the present invention. Adhesive compositions with different ranges of viscosity could be prepared by heating the adhesive monomer composition at mild temperature in the presence of pluronic polymer. The viscosity of the adhesive composition is able to be controlled to any desired level. A method of stabilizing the adhesive composition with a desired level of high viscosity is provided by using the combination of free radical and acid stabilizers. Methods for packaging, sterilizing and applying the adhesive in the medical field are also provided.

    Cyanoacrylate tissue adhesives
    7.
    发明公开
    Cyanoacrylate tissue adhesives 有权
    氰基丙烯酸酯组织粘合剂

    公开(公告)号：EP2742875A1

    公开(公告)日：2014-06-18

    申请号：EP14158536.4

    申请日：2007-11-14

    申请人： Adhezion Biomedical, LLC

    发明人： Lee, Jeoung Soo ,  Webb, Charles Kenneth ,  Zimmerman, Robert ,  Ruiz, Sr., Rafael

    IPC分类号： A61B17/08 ,  A61L24/00 ,  A61L24/04

    CPC分类号： A61K47/32 ,  A61B17/00491 ,  A61K31/513 ,  A61K38/12 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/043 ,  A61L2300/406 ,  A61L2300/408 ,  A61L2300/41 ,  A61L2300/416 ,  C08L35/04 ,  C08L71/02

    摘要： A tissue adhesive including cyanoacrylate and polyethylene glycol (PEG), wherein the PEG remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including cyanoacrylate bulk monomer and cyanoacrylate nanoparticles containing a therapeutic therein. A kit for applying a tissue adhesive, including the tissue adhesive described above and an applicator. Methods of accelerating degradation of a cyanoacrylate tissue adhesive applying a tissue adhesive, closing an internal wound, administering a therapeutic to tissue, treating cancer, and preventing infection in a wound. Methods of method of making a bioabsorbable tissue adhesive and making a therapeutic tissue adhesive.

    摘要翻译： 包含氰基丙烯酸酯和聚乙二醇（PEG）的组织粘合剂，其中所述PEG保持聚醚，并且其中所述组织粘合剂是生物可吸收的。 包含氰基丙烯酸酯本体单体和含有治疗剂的氰基丙烯酸酯纳米粒子的组织粘合剂。 用于施加组织粘合剂的套件包括上述的组织粘合剂和敷贴器。 加速应用组织粘合剂的氰基丙烯酸酯组织粘合剂的降解，闭合内部伤口，对组织施用治疗剂，治疗癌症和防止伤口感染的方法。 制造生物可吸收组织粘合剂和制造治疗组织粘合剂的方法。

    STABLE AND STERILE TISSUE ADHESIVE COMPOSITION WITH A CONTROLLED HIGH VISCOSITY
    8.
    发明公开
    STABLE AND STERILE TISSUE ADHESIVE COMPOSITION WITH A CONTROLLED HIGH VISCOSITY 有权
    稳定无菌Gewebekleberzusammensetzung mit kontrollierter hoherViskosität

    公开(公告)号：EP2679250A1

    公开(公告)日：2014-01-01

    申请号：EP13185231.1

    申请日：2009-06-22

    申请人： Adhezion Biomedical, LLC

    发明人： Ruiz, Rafael ,  Zhang, Sheng

    IPC分类号： A61L24/00 ,  A61L24/06 ,  C09J4/00

    CPC分类号： A61L24/001 ,  A61L24/06 ,  C08L35/04

    摘要： A sterilized cyanoacrylate adhesive composition comprising a cyanoacrylate monomer stabilized with butylated hydroxyl anisole, sulfur dioxide and mixed together with a poloxamer. The adhesive composition is used for medical applications such as in the closure of wounds.

    摘要翻译： 一种灭菌的氰基丙烯酸酯粘合剂组合物，其包含用丁基化羟基苯甲醚稳定的氰基丙烯酸酯单体，二氧化硫并与泊洛沙姆混合在一起。 粘合剂组合物用于医疗应用，例如在伤口闭合中。

    APPLICATORS FOR DISPENSING ADHESIVE OR SEALANT MATERIAL
    9.
    发明公开
    APPLICATORS FOR DISPENSING ADHESIVE OR SEALANT MATERIAL 有权
    APPLIKATOREN ZUR AUSGABE VON HAFT- UND DICHTUNGSMATERIAL

    公开(公告)号：EP2618741A1

    公开(公告)日：2013-07-31

    申请号：EP11761761.3

    申请日：2011-09-15

    申请人： Adhezion Biomedical, LLC

    发明人： RUIZ, Rafael, Sr. ,  ZHANG, Sheng ,  KRAUSS, Martin

    IPC分类号： A61B17/00

    CPC分类号： A61B17/00491

    摘要： An applicator device for storing and dispensing an adhesive or sealant material, which are compatible with irradiation sterilization techniques, the applicator comprising: an applicator body comprising a cutting portion to break the frangible seal of the container for the adhesive, and a grasping and squeezing portion for controlling the flow rate of the adhesive; a container for an adhesive material that is movable relative to the applicator body and is made of materials with high barrier property; and a porous applicator tip that is secured to or frictionally fits into the applicator body.

    摘要翻译： 一种用于存储和分配粘合剂或密封剂材料的涂抹器装置，其与辐射灭菌技术相容，所述涂抹器包括：涂抹器主体，包括切割部分，以破坏用于粘合剂的容器的易碎密封;以及抓握和挤压部分 用于控制粘合剂的流速; 用于粘合剂材料的容器，其相对于涂抹器主体可移动并且由具有高阻隔性的材料制成; 以及固定到或摩擦配合到施用器主体中的多孔施加器尖端。