公开(公告)号：EP3310930B1

公开(公告)日：2019-05-15

申请号：EP16794331.5

申请日：2016-11-10

申请人： Administración General De La Communidad Autónoma De Euskadi ,  Universidad Del Pais Vasco Euskal Herriko Unibertsitatea ,  Basque Center for Macromolecular Design and Engineering, POLYMAT Fundazioa

发明人： LAWRIE, Charles, Henderson ,  BASABE-DESMONTS, Lourdes ,  SCHÄFER, Thomas ,  LIZ MARZÁN, Luis, Manuel ,  PARAK, Wolfgang, Johann

IPC分类号： C12Q1/6823 ,  C12Q1/6827

公开(公告)号：EP3310930A1

公开(公告)日：2018-04-25

申请号：EP16794331.5

申请日：2016-11-10

申请人： Administración General De La Communidad Autónoma De Euskadi ,  Universidad Del Pais Vasco Euskal Herriko Unibertsitatea ,  Basque Center for Macromolecular Design and Engineering, POLYMAT Fundazioa

发明人： LAWRIE, Charles, Henderson ,  BASABE-DESMONTS, Lourdes ,  SCHÄFER, Thomas ,  LIZ MARZÁN, Luis, Manuel ,  PARAK, Wolfgang, Johann

IPC分类号： C12Q1/68 ,  B01L3/00

CPC分类号： C12Q1/6823 ,  B01L3/502707 ,  B01L3/502761 ,  B82Y30/00 ,  C12Q1/6827 ,  C12Q2523/313 ,  C12Q2527/101 ,  C12Q2527/107 ,  C12Q2537/125 ,  C12Q2563/155 ,  C12Q2563/159 ,  C12Q2565/113 ,  C12Q2565/519 ,  C12Q2600/156 ,  G01N33/542 ,  G01N33/54346 ,  C12Q2547/107

摘要： The present invention provides a method for detecting the presence or absence of a target analyte in a test sample, comprising the steps: i) providing a plurality of detector nanoparticles comprising a first detector nanoparticle functionalised with a first probe specific for a first region of a target analyte and a second detector nanoparticle functionalised with a second probe specific for a second region of said target analyte; and ii) contacting said detector nanoparticles with a test sample under conditions suitable for the binding of the specific probes to the target analyte, wherein target analyte-induced agglomeration of the detector nanoparticles permits the release of a detectable signal means from a signal reservoir. Also provided are related devices and systems for performing the method of the invention.