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公开(公告)号：EP3310930B1
公开(公告)日：2019-05-15
申请号：EP16794331.5
申请日：2016-11-10
申请人： Administración General De La Communidad Autónoma De Euskadi , Universidad Del Pais Vasco Euskal Herriko Unibertsitatea , Basque Center for Macromolecular Design and Engineering, POLYMAT Fundazioa
发明人： LAWRIE, Charles, Henderson , BASABE-DESMONTS, Lourdes , SCHÄFER, Thomas , LIZ MARZÁN, Luis, Manuel , PARAK, Wolfgang, Johann
IPC分类号： C12Q1/6823 , C12Q1/6827
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2.发明公开
公开(公告)号：EP4450494A1
公开(公告)日：2024-10-23
申请号：EP23382368.1
申请日：2023-04-20
申请人： Consejo Superior De Investigaciones Científicas , Universidad de Alcalá , Universidad Camilo José Cela , Administración General De La Communidad Autónoma De Euskadi
发明人： MARCO CONTELLES, Josè Luis , TOLEDANO PINEDO, Mireira , PORRO PÉREZ, Alicia , ALMENDROS REQUENA, Pedro , DIEZ IRIEPA, Daniel , IRIEPA CANALDA, Isabel , LÓPEZ MUÑOZ, Francisco , MATHEU FERNÁNDEZ, Ander , ARTETXE ZURUTUZA, Aizpea , ITURRIOZ RODRÍGUEZ, Nerea , MONCHO AMOR, Verónica , SAMPRÓN LEBED, Nicolas , CARRASCO GARCÍA, Estefania
IPC分类号： C07D401/12 , C07D403/12 , A61K31/496 , A61K31/454 , A61K31/404 , A61P35/00
摘要： Indole derivatives of the formulae I to V:
as histone deacetylase (HDAC) inhibitors for the treatment of cancer.-
3.发明公开
公开(公告)号：EP4066754A1
公开(公告)日：2022-10-05
申请号：EP20828993.4
申请日：2020-11-26
摘要： The present invention relates to a surgical guiding device for bone perforation in osteosynthesis processes, comprising a first arm (1) comprising a first toothed ring (2) intended for being arranged on the coronoid; a second arm (4) comprising a second toothed ring (3) intended for resting on the starting point of bone perforation, and onto which an interchangeable head (5) with different sizes intended for guiding the introduction of needles or drill bits can be screwed for performing bone perforation; an intermediate portion (10) made up of respective widened sections (11a and 11b) of the arms (1, 4), which are integrated around a rod (6'), enabling a controlled clamp-type movement between the arms; an ergonomic wheel (6) which enables stable sliding between both arms; and a spring (9) that exerts pressure on the first and second rings (2, 3) compressing the fracture and keeping the assembly stable.
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公开(公告)号：EP2407131B1
公开(公告)日：2014-04-30
申请号：EP10712089.1
申请日：2010-02-26
申请人： Sibel, S.A. , Oreja Puerto, Daniel , Administración General De La Communidad Autónoma De Euskadi
IPC分类号： A61F5/56
CPC分类号： A61F5/56 , A61H11/00 , A61H23/0263 , A61H2201/501 , A61H2201/5064 , A61H2201/5084 , A61H2205/02 , A61H2230/625
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公开(公告)号：EP4410183A2
公开(公告)日：2024-08-07
申请号：EP22835856.0
申请日：2022-09-30
申请人： Universidad del País Vasco/Euskal Herriko Unibertsitatea , Administración General De La Communidad Autónoma De Euskadi
发明人： PINTO, Charles , HERRERO VILLALIBRE, Saioa , CORRAL SAIZ, Javier , DIEZ SÁNCHEZ, Mikel , URÍZAR ARANA, Mónica , MACHO MIER, Erik , CAMPA GÓMEZ, Francisco Javier , TEJADA EZQUERRO, Pedro Ignacio , GARCÍA ORTIZ, María Mar , LÓPEZ MARTÍNEZ, Héctor
CPC分类号： A61B5/4023 , A61B5/1036
摘要： System (1) for diagnosing the balance of a user or patient, comprising a platform (2, 21), a U-shaped support structure (3) and at least three linear actuators (A1, A2, A3) characterized in that the U-shaped support structure (3) partially surrounds the sensor-equipped platform (2) allowing a user access to said platform (2), and in that said structure has guiding elements (70) for guiding the mobile ends (211, 221, 231) of said actuators that allow the vertical displacement of said mobile ends with respect to the structure (3), said mobile ends (211, 221, 231) being mechanically connected to the platform (2, 21) such that when said mobile ends (211, 221, 231) are vertically displaced, they cause the movement of the platform (2, 21).
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公开(公告)号：EP3671761A1
公开(公告)日：2020-06-24
申请号：EP18382973.8
申请日：2018-12-21
发明人： Herran Planchuelo, Jaime , Añorga Gomez, Larraitz , Vergara Micheltorena, Itziar , Vrotsou, Kalliopi , Arauzo Bravo, Marcos Jesus , Matheu Fernández, Ander
摘要： The description relates to a system for assessing the functional performance of an individual, the system comprising a sensor device; a monitoring system, connectable to the sensor device, configured to receive signals coming from the sensor device, pre-process the signals received from the sensor device, extract the main features of the pre-processed signals to be used as predictor variables, assess the functional performance of an individual based on the predictor variables.
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公开(公告)号：EP3051291B1
公开(公告)日：2019-01-30
申请号：EP14796149.4
申请日：2014-09-26
发明人： BOYANO LÓPEZ, María Dolores , ARROLLO BERDUGO, Yoana , ALONSO ALEGRE, Santos , ASUMENDI MALLEA, Aintzane , PÉREZ-YARZA PÉREZ-IREZABAL, Gorka , CAREAGA ALZAGA, Jesús María , GARDEAZABAL GARCÍA, Jesús , IZU BELLOSO, Rosa , DÍAZ RAMÓN, José Luis , ACEBO MARIÑAS, Elvira , SÁNCHEZ DÍEZ, Ana , MARTÍNEZ DELIZARDUY, Íñigo , RATÓN NIETO, Juan Antonio
IPC分类号： G01N33/574
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公开(公告)号：EP3310930A1
公开(公告)日：2018-04-25
申请号：EP16794331.5
申请日：2016-11-10
申请人： Administración General De La Communidad Autónoma De Euskadi , Universidad Del Pais Vasco Euskal Herriko Unibertsitatea , Basque Center for Macromolecular Design and Engineering, POLYMAT Fundazioa
发明人： LAWRIE, Charles, Henderson , BASABE-DESMONTS, Lourdes , SCHÄFER, Thomas , LIZ MARZÁN, Luis, Manuel , PARAK, Wolfgang, Johann
CPC分类号： C12Q1/6823 , B01L3/502707 , B01L3/502761 , B82Y30/00 , C12Q1/6827 , C12Q2523/313 , C12Q2527/101 , C12Q2527/107 , C12Q2537/125 , C12Q2563/155 , C12Q2563/159 , C12Q2565/113 , C12Q2565/519 , C12Q2600/156 , G01N33/542 , G01N33/54346 , C12Q2547/107
摘要： The present invention provides a method for detecting the presence or absence of a target analyte in a test sample, comprising the steps: i) providing a plurality of detector nanoparticles comprising a first detector nanoparticle functionalised with a first probe specific for a first region of a target analyte and a second detector nanoparticle functionalised with a second probe specific for a second region of said target analyte; and ii) contacting said detector nanoparticles with a test sample under conditions suitable for the binding of the specific probes to the target analyte, wherein target analyte-induced agglomeration of the detector nanoparticles permits the release of a detectable signal means from a signal reservoir. Also provided are related devices and systems for performing the method of the invention.
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9.发明公开USE OF METALLOPROTEASE INHIBITORS FOR THE TREATMENT OF POLYCYSTIC LIVER DISEASES 审中-公开VERWENDUNG VON METALLOPROTEASE-INHIBITOREN ZUR BEHANDLUNG VON POLYZYSTISCHEN LEBERERKRANKUNGEN
公开(公告)号：EP2926808A1
公开(公告)日：2015-10-07
申请号：EP13824127.8
申请日：2013-11-27
发明人： BAÑALES ASURMENDI, Jesús María , BUJANDA PIEROLA, Luis , HIJONA MURUAMENDIARAZ, Elizabeth , MÚÑOZ GARRIDO, Patricia , PRIETO VALTUEÑA, Jesús , URRIBARRI, Aura Daniela , GARCÍA MARÍN, José Juan , PERUGORRIA MONTIEL, María Jesús , LOZANO ESTEBAN, Elisa
IPC分类号： A61K31/16 , A61K31/203 , A61P1/16
CPC分类号： A61K31/185 , A61K31/16 , A61K31/203 , A61K31/4166 , A61K31/4406 , A61K31/541 , A61K31/575 , A61K38/31 , A61K45/06 , A61K2300/00
摘要： The present invention comprises the use of metalloprotease inhibitors for the treatment of polycystic liver diseases (PLDs). The invention particularly describes the use of Marimastat as the preferred metalloprotease inhibitor for the treatment of PLDs. Treatment with Marimastat is able to inhibit liver cystogenesis by blocking metalloproteolytic hyperactivity of polycystic cholangiocytes.
摘要翻译： 本发明包括使用金属蛋白酶抑制剂治疗多囊肝病（PLD）。 本发明特别描述了Marimastat作为优选的金属蛋白酶抑制剂用于治疗PLD的用途。 Marimastat的治疗能够通过阻断多囊性胆管细胞的金属蛋白酶解多动症来抑制肝脏的发生。
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公开(公告)号：EP2740446B1
公开(公告)日：2015-02-25
申请号：EP14156860.0
申请日：2010-02-26
申请人： Sibel, S.A. , Oreja Puerto, Daniel , Administración General De La Communidad Autónoma De Euskadi
IPC分类号： A61F5/56
CPC分类号： A61F5/56 , A61H11/00 , A61H23/0263 , A61H2201/501 , A61H2201/5064 , A61H2201/5084 , A61H2205/02 , A61H2230/625
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