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公开(公告)号：EP1653925A1
公开(公告)日：2006-05-10
申请号：EP04780995.9
申请日：2004-08-11
IPC分类号： A61K9/14
CPC分类号： A61K9/1617 , A61K9/1635 , A61K9/1647 , A61K9/1652 , A61K31/43 , C07D499/00
摘要： Compositions and methods for making robust pellets that contain a high percentage, by weight, of active drug agent, and which also contain additional components that enhance the absorption and solubility of the active drug agent within the gastrointestinal tract (GI tract) without diminishing the robust nature of the pellet, are disclosed.
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公开(公告)号：EP1648415A2
公开(公告)日：2006-04-26
申请号：EP04757155.9
申请日：2004-07-20
CPC分类号： A61K9/5084 , A61K9/2077 , A61K9/4808
摘要： An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, a delayed release dosage form, and a sustained release dosage form, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
摘要翻译： 抗生素产品由至少三种剂型组成，每种剂型具有不同的释放曲线，抗生素产品的Cmax在小于约十二小时内达到。 在一个实施方案中，存在速释剂型，延迟释放剂型和持续释放剂型，每种剂型具有不同的释放曲线，其中每个剂型在不同时间达到Cmax。
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公开(公告)号：EP1648418A2
公开(公告)日：2006-04-26
申请号：EP04778631.4
申请日：2004-07-20
CPC分类号： A61K9/4808 , A61K9/2077
摘要： An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more sustained release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
摘要翻译： 抗生素产品由至少三种剂型组成，每种剂型具有不同的释放曲线，抗生素产品的Cmax在小于约十二小时内达到。 在一个实施方案中，存在速释剂型以及两种或更多种持续释放剂型，每种剂型具有不同的释放曲线，其中每个剂型在不同时间达到Cmax。
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公开(公告)号：EP1973530A2
公开(公告)日：2008-10-01
申请号：EP06849097.8
申请日：2006-12-22
发明人： FLANNER, Henry, H. , TREACY, Donald , TOLLE-SANDER, Sanna , IBRAHIM, Scott , SCHESTOPOL, Marcus , BURNSIDE, Beth, A.
CPC分类号： A61K9/0004 , A61K9/0065 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/2081 , A61K9/2086 , A61K9/209 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5073 , A61K9/5084
摘要： Disclosed are pharmaceutical products for providing pulses of at least one pharmaceutically active ingredient from a patient's stomach, or from a subsequent gastrointestinal site proximal thereto, for absorption thereof at a site(s) more distal in the gastrointestinal tract than the patient's stomach, or than the subsequent gastrointestinal site proximal thereto. The product comprises first, second, and third pharmaceutical dosage forms, each of which' comprises at least one pharmaceutically active agent and a pharmaceutically acceptable carrier. The product is formulated such that at least two of the first, second, and third pharmaceutical dosage forms further comprise means for providing temporary gastric-retention of the at least two of the first, second, and third pharmaceutical dosage forms within the patient's stomach, or at the subsequent gastrointestinal site proximal thereto.
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公开(公告)号：EP1771158A1
公开(公告)日：2007-04-11
申请号：EP05769422.6
申请日：2005-07-01
申请人： Advancis Pharmaceutical Corporation , Cao, Bruce , Wassink, Sandra E. , Treacy, Donald , Burnside, Beth A. , Rowlings, Colin E. , Bonck, John A.
发明人： CAO, Bruce , WASSINK, Sandra, E. , TREACY, Donald , BURNSIDE, Beth, A. , ROWLINGS, Colin, E. , BONCK, John, A.
IPC分类号： A61K9/16
CPC分类号： A61K9/209 , A61K9/2081 , A61K9/2846 , A61K9/5026 , A61K9/5084 , A61K31/43 , A61K31/545 , A61K31/7048
摘要： A pharmaceutical tablet comprising an immediate release portion containing an active ingredient and a delayed release portion, wherein the delayed release portion comprises an enteric-coated layer and within the enteric-coated layer there is at least one member selected from the group consisting of enteric-coated microparticle dosage forms containing an active ingredient and enteric-coated mini-tablet dosage forms containing an active ingredient, is disclosed.
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公开(公告)号：EP1658034A2
公开(公告)日：2006-05-24
申请号：EP04781957.8
申请日：2004-08-20
IPC分类号： A61K6/00
CPC分类号： A61K31/00 , A61K9/1635 , A61K9/1652 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2846 , A61K9/2866 , A61K9/5026 , A61K9/5042 , A61K9/5084 , A61K31/43 , A61K31/496 , A61K31/546 , A61K31/7048
摘要： An antibiotic product is comprised of at least three dosage forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours after the initial release of antibiotic. In one embodiment, there are two delayed release dosage forms, as well as a delayed sustained release dosage form, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
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7.发明公开
公开(公告)号：EP1968586A2
公开(公告)日：2008-09-17
申请号：EP06845116.0
申请日：2006-12-08
发明人： FLANNER, Henry, H. , GUTTENDORF, Robert, J. , CLAUSEN, Susan, P. , TREACY, Donald , BURNSIDE, Beth, A.
IPC分类号： A61K31/43
CPC分类号： A61K31/43
摘要： Disclosed are once-a-day penicillin-type antibiotic products, comprising at least one modified release dosage form comprising penicillin-type antibiotics and pharmaceutically acceptable carriers, that are administered once-a-day in a dosage and for a number of days that provide a Total T>MIC that is sufficient to achieve at least the minimum amount of bacterial eradication for treatment of a bacterial infection. In one embodiment the products provide a T>MIC90 in the serum for at least 5 hours (preferably for at least five consecutive hours), within a 24-hour dosing interval, for a given bacterial pathogen's MIC90, while providing a total dosage of the penicillin-type antibiotic for a 24-hour dosing interval.
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公开(公告)号：EP1653924A2
公开(公告)日：2006-05-10
申请号：EP04780937.1
申请日：2004-08-12
CPC分类号： A61K9/2081 , A61K9/1694 , A61K9/5084
摘要： An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours after the initial release of antibiotic. In one embodiment, there is a delayed release dosage form, as well as two or more delayed sustained release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
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公开(公告)号：EP1648407A2
公开(公告)日：2006-04-26
申请号：EP04778705.6
申请日：2004-07-20
IPC分类号： A61K9/00
CPC分类号： A61K31/54 , A61K9/2077 , A61K31/545 , A61K31/7048
摘要： An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, a sustained release dosage form, and a delayed release dosage form, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
摘要翻译： 抗生素产品由至少三种剂型组成，每种剂型具有不同的释放曲线，抗生素产品的Cmax在小于约十二小时内达到。 在一个实施方案中，存在速释剂型，缓释剂型和延迟释放剂型，每种剂型具有不同的释放曲线，其中每个剂型在不同时间达到Cmax。
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公开(公告)号：EP1663169A1
公开(公告)日：2006-06-07
申请号：EP04783885.9
申请日：2004-09-14
IPC分类号： A61K9/22
CPC分类号： A61K9/5073 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/2077 , A61K9/2081 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5084 , A61K45/06
摘要： An antibiotic product is comprised of at least three dosage forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours after the initial release of antibiotic. In one embodiment, there are two delayed release dosage forms, as well as a delayed sustained release dosage form, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.
摘要翻译： 抗生素产品由至少三种剂型组成，每种剂型具有不同的释放曲线，抗生素产品的Cmax在抗生素初始释放后小于约12小时内达到。 在一个实施方案中，存在两种延迟释放剂型以及延迟缓释剂型，每种剂型具有不同的释放曲线，其中每种剂型在不同时间达到Cmax。
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