公开(公告)号：EP2376058A1

公开(公告)日：2011-10-19

申请号：EP09796554.5

申请日：2009-12-18

申请人： Aerie Pharmaceuticals, Inc.

发明人： KOPCZYNSKI, Casey ,  LIN, Cheng-Wen ,  SUTAY, Chris

IPC分类号： A61K9/00 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36

CPC分类号： A61K9/0051 ,  A61K31/00

摘要： Drug delivery devices comprising a non-bioabsorbable polymer structure and a composition comprising an active agent have been discovered. The drug delivery devices may be used to treat ocular conditions, among other diseases and conditions. In addition, a method of treating an ocular condition has been discovered comprising implanting a drug delivery device which releases the active agent at a rate of Q = 0.001 x N x C wherein C is the topical effective concentration (in milligram/mL) of the active agent and N=0.01 to 0.5 for prostaglandins in their ester, amide, free acid or salt form, and N=0.5 to 5 for any active agent other than prostaglandins in their ester, amide, free acid or salt form.

公开(公告)号：EP2571526A1

公开(公告)日：2013-03-27

申请号：EP11784089.2

申请日：2011-05-17

申请人： Aerie Pharmaceuticals, Inc.

发明人： KOPCZYNSKI, Casey ,  LIN, Cheng-Wen ,  SUTAY, Chris

IPC分类号： A61K47/32

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61K31/00 ,  A61K31/215 ,  A61K47/32 ,  A61K47/36

摘要： Drug delivery devices comprising a non-bioabsorbable polymer structure configured to support a composition comprising an active agent. The devices include a plurality of portions fused together and a recess configured to support the composition. At least one of the portions includes an impermeable polymer and at least one other portion includes a rate-limiting water-permeable polymer. The rate-limiting water-permeable polymer allows for transportation of the active agent to an exterior of the device.