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12 条记录 (耗时 0.011 秒)

    COMBINATION THERAPY
    1.
    发明公开
    COMBINATION THERAPY 审中-实审

    公开(公告)号：EP4335507A2

    公开(公告)日：2024-03-13

    申请号：EP23199180.3

    申请日：2014-03-14

    申请人： Aerie Pharmaceuticals, Inc.

    发明人： KOPCZYNSKI, Casey ,  LIN, Cheng-Wen ,  STURDIVANT, Jill Marie ,  DELONG, Mitchell, A

    IPC分类号： A61P27/06

    摘要： Described herein are compounds and compositions for treating glaucoma and/or reducing intraocular pressure. Compositions may comprise an isoquinoline compound and a prostaglandin or a prostaglandin analog. Compounds described herein include those in which an isoquinoline compound is covalently linked to a prostaglandin or a prostaglandin analog, and those in which an isoquinoline compound and a prostaglandin free acid together form a salt.

    COMBINATION THERAPY
    5.
    发明公开
    COMBINATION THERAPY 审中-公开
    联合治疗

    公开(公告)号：EP2976080A1

    公开(公告)日：2016-01-27

    申请号：EP14719999.6

    申请日：2014-03-14

    申请人： Aerie Pharmaceuticals, Inc.

    发明人： KOPCZYNSKI, Casey ,  LIN, Cheng-wen ,  STURDIVANT, Jill, Marie ,  DELONG, Mitchell, A.

    IPC分类号： A61K31/47 ,  A61K31/557 ,  A61P27/06

    摘要： Described herein are compounds and compositions for treating glaucoma and/or reducing intraocular pressure. Compositions may comprise an isoquinoline compound and a prostaglandin or a prostaglandin analog. Compounds described herein include those in which an isoquinoline compound is covalently linked to a prostaglandin or a prostaglandin analog, and those in which an isoquinoline compound and a prostaglandin free acid together form a salt.

    摘要翻译： 本文描述了用于治疗青光眼和/或降低眼内压的化合物和组合物。 组合物可以包含异喹啉化合物和前列腺素或前列腺素类似物。 本文所述的化合物包括其中异喹啉化合物与前列腺素或前列腺素类似物共价连接的化合物，以及其中异喹啉化合物和前列腺素游离酸一起形成盐的化合物。

    DRUG DELIVERY DEVICES FOR DELIVERY OF THERAPEUTIC AGENTS
    6.
    发明公开
    DRUG DELIVERY DEVICES FOR DELIVERY OF THERAPEUTIC AGENTS 审中-公开
    药物输送装置用于治疗剂递送

    公开(公告)号：EP2376058A1

    公开(公告)日：2011-10-19

    申请号：EP09796554.5

    申请日：2009-12-18

    申请人： Aerie Pharmaceuticals, Inc.

    发明人： KOPCZYNSKI, Casey ,  LIN, Cheng-Wen ,  SUTAY, Chris

    IPC分类号： A61K9/00 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36

    CPC分类号： A61K9/0051 ,  A61K31/00

    摘要： Drug delivery devices comprising a non-bioabsorbable polymer structure and a composition comprising an active agent have been discovered. The drug delivery devices may be used to treat ocular conditions, among other diseases and conditions. In addition, a method of treating an ocular condition has been discovered comprising implanting a drug delivery device which releases the active agent at a rate of Q = 0.001 x N x C wherein C is the topical effective concentration (in milligram/mL) of the active agent and N=0.01 to 0.5 for prostaglandins in their ester, amide, free acid or salt form, and N=0.5 to 5 for any active agent other than prostaglandins in their ester, amide, free acid or salt form.