公开(公告)号：EP2044145A1

公开(公告)日：2009-04-08

申请号：EP06790214.8

申请日：2006-09-12

申请人： Agency for Science, Technology and Research

发明人： YING, Jackie, Y. ,  CHOW, Edwin Pei Yong ,  LOH, Jeremy Ming Hok ,  SCHUMACHER, Karl

IPC分类号： C08J9/00 ,  A61P27/00

CPC分类号： A61L27/56 ,  B33Y80/00

摘要： Porous polymeric articles, and more specifically, porous polymeric articles for tissue engineering and organ replacement, are described. In some embodiments, methods described herein include use of a polymer-solvent system (e.g., phase inversion) to generate porosity in a structure. The process may include formation of a structure precursor material including a first crosslinkable component and a second component that can be precipitated in a precipitation medium. The structure precursor material may be shaped into a three-dimensional shape by a suitable technique such as three- dimensional printing. Upon shaping of the structure precursor material, at least a portion of the first component may be crosslinked. The structure may then be contacted with a precipitation medium to remove the precursor solvent from the structure, which can cause the second polymer component to precipitate and form a porous structure containing a network of uniform pores. In some embodiments, the porous structure is constructed and arranged for use as a template for ultrafiltration, cell growth, and/or for forming complex, biomimetic, porous biohybrid organs, where living cells can be immobilized and perform their normal physiological functions.

摘要翻译： 描述了多孔聚合物制品，更具体地说，用于组织工程和器官置换的多孔聚合物制品。 在一些实施方案中，本文所述的方法包括使用聚合物 - 溶剂体系（例如相转化）以在结构中产生孔隙。 该方法可以包括形成包含可在沉淀介质中沉淀的第一可交联组分和第二组分的结构前体材料。 结构前体材料可以通过诸如三维印刷的合适技术成形为三维形状。 在结构前体材料成形时，第一组分的至少一部分可以是交联的。 然后可以将结构与沉淀介质接触以从结构中除去前体溶剂，这可使第二聚合物组分沉淀并形成含有均匀孔网络的多孔结构。 在一些实施方案中，构造和布置多孔结构以用作超滤，细胞生长和/或形成复合物，仿生性，多孔生物杂交器官的模板，其中活细胞可被固定并进行其正常的生理功能。