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公开(公告)号：EP2255030A1
公开(公告)日：2010-12-01
申请号：EP09715162.5
申请日：2009-03-02
IPC分类号： D01D5/06
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
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公开(公告)号：EP2044145A1
公开(公告)日：2009-04-08
申请号：EP06790214.8
申请日：2006-09-12
摘要： Porous polymeric articles, and more specifically, porous polymeric articles for tissue engineering and organ replacement, are described. In some embodiments, methods described herein include use of a polymer-solvent system (e.g., phase inversion) to generate porosity in a structure. The process may include formation of a structure precursor material including a first crosslinkable component and a second component that can be precipitated in a precipitation medium. The structure precursor material may be shaped into a three-dimensional shape by a suitable technique such as three- dimensional printing. Upon shaping of the structure precursor material, at least a portion of the first component may be crosslinked. The structure may then be contacted with a precipitation medium to remove the precursor solvent from the structure, which can cause the second polymer component to precipitate and form a porous structure containing a network of uniform pores. In some embodiments, the porous structure is constructed and arranged for use as a template for ultrafiltration, cell growth, and/or for forming complex, biomimetic, porous biohybrid organs, where living cells can be immobilized and perform their normal physiological functions.
摘要翻译： 描述了多孔聚合物制品，更具体地说，用于组织工程和器官置换的多孔聚合物制品。 在一些实施方案中，本文所述的方法包括使用聚合物 - 溶剂体系（例如相转化）以在结构中产生孔隙。 该方法可以包括形成包含可在沉淀介质中沉淀的第一可交联组分和第二组分的结构前体材料。 结构前体材料可以通过诸如三维印刷的合适技术成形为三维形状。 在结构前体材料成形时，第一组分的至少一部分可以是交联的。 然后可以将结构与沉淀介质接触以从结构中除去前体溶剂，这可使第二聚合物组分沉淀并形成含有均匀孔网络的多孔结构。 在一些实施方案中，构造和布置多孔结构以用作超滤，细胞生长和/或形成复合物，仿生性，多孔生物杂交器官的模板，其中活细胞可被固定并进行其正常的生理功能。
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3.发明授权HIGH-THROUGHPUT CELL-BASED ASSAYS FABRICATED WITH INTEGRATED SILICON AND CELL CULTURE TECHNOLOGIES 有权生成的测试程序对电池的集成硅及细胞培养技术基于高通量
公开(公告)号：EP1979466B8
公开(公告)日：2012-10-24
申请号：EP06849257.8
申请日：2006-12-20
发明人： KAN, Shyi-herng , YING, Jackie, Y. , YU, Hanry , SCHUMACHER, Karl , NG, Susanne, San San , SUN, Wanxin
CPC分类号： C12N5/0068 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0887 , C12M23/20 , C12M23/34 , C12M25/02 , C12N2533/10 , C12N2533/54 , C12N2535/10
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公开(公告)号：EP2482867A1
公开(公告)日：2012-08-08
申请号：EP10820925.5
申请日：2010-10-04
发明人： YING, Jackie Y. , CHOW, Edwin Pei Yong , TEO, Jeremy C.M. , SCHUMACHER, Karl , LOH, Jeremy Ming Hock , QI, Rosa Yue , ONG, Qunya
CPC分类号： B01D63/085 , A61F2/022 , A61M1/14 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M2205/3331 , A61M2209/088 , B01D61/145 , B01D69/141 , B01D2319/025 , B01D2319/06 , C12M23/54 , C12M25/02 , C12M29/04
摘要： The present invention generally relates to improved bioartificial kidneys (BAKs), and in certain embodiments to improved bioartificial kidneys that are portable and/or wearable by a user. In some embodiments, the BAKs may comprise an ultrafiltration unit and a reabsorption unit. The reabsorption unit may contain a reabsorption membrane having a layer of renal proximal tubule cells disposed thereon, where the renal proximal tubule cells selectively allow solutes to pass through the reabsorption membrane. In some embodiments, at least the reabsorption unit may be configured as a substantially flat-plate filtration device, which can impart advantageous properties such as improved maintenance of the renal proximal tubule cell layer, more facile monitoring of the renal proximal tubule cell layer as well as enhanced profile for wearability.
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5.发明公开MANIPULATION OF CHEMICAL AND/OR BIOLOGICAL SPECIES USING MAGNETIC FIELD MODULATORS 审中-公开化学和/或生物物种操纵利用磁场调节剂
公开(公告)号：EP1963487A2
公开(公告)日：2008-09-03
申请号：EP06838895.8
申请日：2006-12-01
IPC分类号： C12N5/00
CPC分类号： C12N5/0062 , C12N2535/10
摘要： Methods and apparatuses for manipulating chemical and/or biological species (e.g., cells) and using magnetic fields are provided. The methods may involve patterning magnetically-susceptible cells using a magnetic field modulator. For instance, when a fluid containing cells is brought in contact with a surface and the magnetic field modulator is positioned proximate the surface, the cells may form a pattern by aligning with portions of the modulated magnetic field. Advantageously, in certain embodiments, the magnetic field modulator is not integrally connected to the surface. Thus, patterns of cells can be formed on various types of surfaces and the magnetic field modulator may be repositioned without altering the surface. Patterns comprising multiple cell types on a single surface can also be formed. Such patterns may be useful for studying cell-cell interactions and for forming three-dimensional cellular structures (e.g., tissues).
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6.发明公开HIGH-THROUGHPUT CELL-BASED ASSAYS FABRICATED WITH INTEGRATED SILICON AND CELL CULTURE TECHNOLOGIES 有权生成的测试程序对电池的集成硅及细胞培养技术基于高通量
公开(公告)号：EP1979466A2
公开(公告)日：2008-10-15
申请号：EP06849257.8
申请日：2006-12-20
发明人： KAN, Shyi-herng , YING, Jackie, Y. , YU, Hanry , SCHUMACHER, Karl , NG, Susanne, San San , SUN, Wanxin
CPC分类号： C12N5/0068 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0887 , C12M23/20 , C12M23/34 , C12M25/02 , C12N2533/10 , C12N2533/54 , C12N2535/10
摘要： The present invention relates to articles and methods involving porous materials (e.g., membranes) which may interact with species, such as biological molecules, cells, etc., whereby the species may adhere to or become immobilized with respect to a surface of the porous material or an adhesion layer coating the porous surface. The porous material may be capable of attaching species with control over the positioning and spatial distribution of the species across the surface of the material. Such articles and methods may be useful in, for example, biological assays, biological sensors, or in the culturing of biological cells.
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