公开(公告)号：EP3004330A1

公开(公告)日：2016-04-13

申请号：EP14807294.5

申请日：2014-06-05

申请人： Agency for Science, Technology and Research

发明人： CHEN, Qingfeng ,  KENG, Choong Tat ,  TAN, Yee Joo ,  BERTOLETTI, Antonio

IPC分类号： C12N5/071 ,  C12N5/073 ,  C12N5/0735

CPC分类号： A01K67/0271 ,  A01K2207/12 ,  A01K2217/054 ,  A01K2227/105 ,  A01K2267/0337 ,  A61K49/0008 ,  C12N2770/24211

摘要： This invention refers to a mouse for human hepatitis studies wherein the mouse has been injected with CD34+ stem cells and wherein the mouse is immunocompromised, as well as a method of manufacturing a mouse model comprising administering CD34+ stem cells as defined herein into an immunocompromised mouse as defined herein. The invention also refers to the use of a mouse as defined for testing the efficiency of putative anti-HBV or anti-HCV drugs or for characterizing changes in viral quasispecies during HBV or HCV infection.

摘要翻译： 本发明涉及用于人肝炎研究的小鼠，其中小鼠已注射CD34 +干细胞并且其中小鼠免疫受损，以及制造小鼠模型的方法，该方法包括将如本文所定义的CD34 +干细胞施用至免疫受损小鼠中 在此定义。 本发明还涉及定义用于测试推定的抗-HBV或抗-HCV药物的效率或用于表征HBV或HCV感染期间病毒准种的变化的小鼠的用途。

公开(公告)号：EP1701977A2

公开(公告)日：2006-09-20

申请号：EP04806327.5

申请日：2004-12-10

申请人： Agency for Science, Technology and Research

发明人： SHEN, Shuo ,  HONG, Wanjin ,  LIM, Seng Gee ,  TAN, Yee Joo ,  FIELDING, Burtram Clinton ,  GOH, Phuay Yee ,  TAN, Timothy Hoe Peng ,  FU, Jian Lin

IPC分类号： C07K14/165 ,  C07K16/10 ,  C12N15/50 ,  G01N33/68 ,  A61K39/215 ,  A61P31/14

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/215 ,  A61K2039/57 ,  C07K16/10 ,  C07K2317/76 ,  C07K2319/23 ,  C12N2710/14143 ,  C12N2770/20022 ,  C12N2770/20034

摘要： The present invention relates to the use of a matured, glycosylated Spike (S) protein of SARS Coronavirus, fragments of the S protein, methods for producing the same, their use in detecting SARS infection, and their use or the use of their corresponding antibodies to treat patients suffering from SARS.