公开(公告)号：EP4436984A1

公开(公告)日：2024-10-02

申请号：EP22840425.7

申请日：2022-11-23

申请人： Flagship Pioneering Innovations VI, LLC

发明人： KAHVEJIAN, Avak ,  DE BOER, Alexandra Sophie ,  ECHELARD, Yann Paul Guy Régis ,  NELSON, Jennifer A. ,  LEE, Soohyun ,  MELFI, Michael Donato ,  MOSAHEB, Mohammad Mubeen ,  SIGOVA, Alla Alexeevna

IPC分类号： C07K14/165 ,  A61K39/215 ,  A61P31/14

CPC分类号： A61K39/215 ,  A61P31/14 ,  A61K2039/5320130101 ,  A61K2039/54520130101 ,  A61K2039/5556620130101 ,  A61K2039/5555520130101 ,  A61K39/145 ,  A61K2039/57520130101 ,  A61K2039/57220130101 ,  A61K2039/5553820130101 ,  A61K2039/7020130101 ,  A61P31/16 ,  A61K39/12 ,  C12N2760/1613420130101 ,  C12N2770/2003420130101 ,  C12N2770/2007120130101 ,  A61K2039/5551120130101 ,  C07K14/005

公开(公告)号：EP4404960A1

公开(公告)日：2024-07-31

申请号：EP22793268.8

申请日：2022-09-22

申请人： BioNTech SE

发明人： GAYNOR, Richard B. ,  SRINIVASAN, Lakshmi ,  PORAN, Asaf ,  HARJANTO, Dewi ,  ARIETA, Christina Murphy ,  ROTHENBERG, Daniel Abram ,  SROUJI, John ,  KRUMM, Stefanie ,  THANKI, Kaushik ,  VOGEL, Annette ,  SAHIN, Ugur ,  XIE, Yushu Joy

IPC分类号： A61K39/215 ,  A61P31/14 ,  C07K14/00

CPC分类号： A61K39/215 ,  A61P31/14 ,  C12N2770/2003420130101 ,  C12N2770/2007120130101 ,  C07K14/005 ,  C07K14/7051 ,  C07K2319/03620130101 ,  C12N2770/2002220130101

公开(公告)号：EP4361170A1

公开(公告)日：2024-05-01

申请号：EP22828540.9

申请日：2022-06-24

申请人： Watanabe, Yoshihiro

发明人： KAWANO, Mitsuhiro ,  HOSOKAWA, Natsuko ,  MIURA, Tomoyuki ,  WATANABE, Yoshihiro

IPC分类号： C07K14/165 ,  A61K39/215 ,  A61P31/14 ,  A61P37/04

CPC分类号： C07K14/165 ,  A61P37/04 ,  A61K39/215 ,  A61P31/14

摘要： The invention provides an antibody-inducing polypeptide that is useful for treatment or prevention of SARS-CoV-2 infection in a subject and a vaccine that comprises such antibody-inducing polypeptide. The polypeptide is selected from the group of polypeptides (a) to (f) below and has antibody-inducing properties: (a) a polypeptide consisting of 7 or more continuous amino acids in a region of positions 336 to 361, 406 to 432, or 446 to 480 of SEQ ID NO: 1; (b) a polypeptide comprising an amino acid sequence having 80% or higher sequence identity to the amino acid sequence of any polypeptide as defined in (a); (c) a polypeptide comprising the polypeptide as defined in (a) or (b) as a partial sequence and comprising no region other than the partial sequence of SEQ ID NO: 1; (d) a polypeptide consisting of 10 or more continuous amino acids in a region of positions 1144 to 1161 or 1174 to 1202 of SEQ ID NO: 1; (e) a polypeptide comprising an amino acid sequence having 80% or higher sequence identity to the amino acid sequence of any polypeptide as defined in (d); and (f) a polypeptide comprising the polypeptide as defined in (d) or (e) as a partial sequence and comprising no region other than the partial sequence of SEQ ID NO: 1.

公开(公告)号：EP3411055A1

公开(公告)日：2018-12-12

申请号：EP17706342.7

申请日：2017-02-02

申请人： Merial, Inc.

发明人： RUTTEN, Alphons ,  POMMELLET, Caroline ,  CHICOTEAU, Pierre

IPC分类号： A61K36/87 ,  A61K33/04 ,  A61K9/00 ,  A23K10/00

CPC分类号： A61K36/87 ,  A23K10/37 ,  A23K20/10 ,  A23K20/20 ,  A23K20/22 ,  A23K20/30 ,  A23K50/30 ,  A23K50/60 ,  A23K50/75 ,  A61K9/0007 ,  A61K9/0095 ,  A61K33/04 ,  A61K39/12 ,  A61K39/215 ,  A61K47/02 ,  A61K47/12 ,  A61K2039/542 ,  A61K2039/544 ,  A61K2039/545 ,  A61K2039/552 ,  C12N7/00 ,  C12N2720/10034 ,  C12N2770/20034 ,  Y02P60/877 ,  A61K2300/00

摘要： The present invention encompasses an effervescent Grape extract plus selenium composition which improves stress response. The invention also encompasses methods of improving stress response, such as stress response to vaccination or weaning, by administration of the composition. The invention also encompasses methods of producing meat with improved quality by raising an animal on a diet supplemented with an effervescent Grape extract plus selenium composition.

公开(公告)号：EP3116539B1

公开(公告)日：2018-10-10

申请号：EP15712230.0

申请日：2015-03-10

申请人： Regents of the University of Minnesota

发明人： MARTHALER, Douglas ,  ROSSOW, Kurt

IPC分类号： A61K39/215 ,  C07K14/165 ,  C12N7/00

CPC分类号： A61K39/215 ,  A61K2039/525 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/55583 ,  C07K14/165 ,  C12N7/00 ,  C12N2770/00021 ,  C12N2770/00022 ,  C12N2770/20034

摘要： The present disclosure provides an isolated or purified Porcine Epidemic Diarrhea Virus (PEDV) or Porcine Epidemic Diarrhea Virus (PEDV) S1 protein, and methods of use thereof.

公开(公告)号：EP3184120A1

公开(公告)日：2017-06-28

申请号：EP14786282.5

申请日：2014-08-22

申请人： Investigacion Aplicada, S.A. de C.V.

发明人： LUCIO DECANINI, Eduardo ,  MORALES GARZON, José, Andrés

IPC分类号： A61K39/395 ,  A61K39/42 ,  C07K16/02

CPC分类号： A61K39/39 ,  A61K39/0002 ,  A61K39/002 ,  A61K39/0258 ,  A61K39/0275 ,  A61K39/08 ,  A61K39/102 ,  A61K39/12 ,  A61K39/15 ,  A61K39/215 ,  A61K2039/505 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55583 ,  A61K2039/575 ,  A61K2039/70 ,  C07K16/02 ,  C07K16/081 ,  C07K16/10 ,  C07K16/1242 ,  C07K16/44 ,  C07K2317/11 ,  C07K2317/23 ,  C07K2317/76 ,  C12N7/00 ,  C12N2710/18034 ,  C12N2720/12334 ,  C12N2770/10034 ,  C12N2770/20034

摘要： The present invention relates to a therapy for treating or preventing several diseases in animals, based on the administration of a highly concentrated avian derived immunoglobulins formulation, obtained from the egg yolk from hens previously hiper-immunized with a vaccine formulation comprising infectious agents or toxins antigens, a light mineral oil and a particulate adjuvant.

摘要翻译： 本发明涉及一种治疗或预​​防动物中几种疾病的疗法，其基于给予高度浓缩的禽源性免疫球蛋白制剂，所述高度浓缩的禽源性免疫球蛋白制剂从先前用包含传染原或毒素抗原的疫苗制剂预先免疫的母鸡的蛋黄中获得 ，轻质矿物油和颗粒状辅助剂。

公开(公告)号：EP3166634A2

公开(公告)日：2017-05-17

申请号：EP15747614.4

申请日：2015-07-08

申请人： Zoetis Services LLC

发明人： MARX, Jacqueline, Gayle ,  HARDHAM, John, Morgan ,  DOMINOWSKI, Paul, J. ,  RAPP GABRIELSON, Vicki, Jon ,  BALASCH, Sanuy, Monica ,  CABANA, Sumsi, Marta ,  PLAJA, Dilme, Laia ,  URNIZA, Hostench, Alicia ,  ROMERO, Galindo, Oscar

IPC分类号： A61K39/215 ,  C07K14/165 ,  C12N7/00 ,  A61K39/00

CPC分类号： A61K39/215 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/575 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20063 ,  C12N2770/20071

摘要： The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.

摘要翻译： 本发明涉及保护猪免受由猪流行性腹泻病毒（PEDV）引起的疾病的新的免疫原性组合物。 本发明还涉及新的免疫原性组合物，其保护猪免于由单独的猪或猪冠状病毒（PDCoV）引起的疾病或作为保护免受PEDV的组合疫苗。 本发明的组合物提供杀死的病毒，其效力通过选择优选的佐剂而增强。 新的培养方法也被用来提高培养病毒的可重复产量。 活疫苗也由Calaf14 PEDV分离株提供。

公开(公告)号：EP3116539A1

公开(公告)日：2017-01-18

申请号：EP15712230.0

申请日：2015-03-10

申请人： Regents of the University of Minnesota

发明人： MARTHALER, Douglas ,  ROSSOW, Kurt

IPC分类号： A61K39/215 ,  C07K14/165 ,  C12N7/00

CPC分类号： A61K39/215 ,  A61K2039/525 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/55583 ,  C07K14/165 ,  C12N7/00 ,  C12N2770/00021 ,  C12N2770/00022 ,  C12N2770/20034

摘要： The present disclosure provides an isolated or purified Porcine Epidemic Diarrhea Virus (PEDV) or Porcine Epidemic Diarrhea Virus (PEDV) S1 protein, and methods of use thereof.

摘要翻译： 本公开提供了分离或纯化的猪流行性腹泻病毒（PEDV）或猪流行性腹泻病毒（PEDV）S1蛋白及其使用方法。

公开(公告)号：EP2950817A4

公开(公告)日：2016-09-07

申请号：EP14745410

申请日：2014-01-31

申请人： UNIV PORTLAND STATE ,  PROVIDENCE HEALTH & SERVICES OREGON

发明人： STEDMAN KENNETH M ,  LAIDLER JAMES R ,  BAHJAT KEITH

IPC分类号： A61K39/12

CPC分类号： A61K39/12 ,  A61K39/125 ,  A61K39/13 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61K39/235 ,  A61K39/285 ,  A61K39/29 ,  A61K39/292 ,  A61K2039/525 ,  A61K2039/5252 ,  A61K2039/55505 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55588 ,  C12N7/00 ,  C12N2710/10021 ,  C12N2710/10034 ,  C12N2710/24121 ,  C12N2710/24134 ,  C12N2720/12321 ,  C12N2720/12334 ,  C12N2740/16021 ,  C12N2740/16034 ,  C12N2760/16021 ,  C12N2760/16034 ,  C12N2770/20021 ,  C12N2770/20034 ,  C12N2770/24021 ,  C12N2770/24034 ,  C12N2770/24221 ,  C12N2770/24234 ,  C12N2770/32421 ,  C12N2770/32434 ,  C12N2770/32621 ,  C12N2770/32634 ,  C12N2795/10134 ,  C12N2795/14034

摘要： It is disclosed herein that viruses coated in silica retain infectivity and the capacity to induce an immune response in an infected host. In addition, silicified virus is remarkably resistant to desiccation. Provided herein are methods of inducing a virus-specific immune response in a subject by administering to the subject an effective amount of silicified virus or silicified virus particles. Methods of enhancing a virus-specific cell-mediated immune response (such as a T cell-mediated immune response) in a subject by administering to the subject a silicified virus or silicified virus particles are also described herein. Further provided are immunogenic compositions comprising silicified virus or silicified virus particles, such as compositions useful as vaccines. The immunogenic compositions include a pharmaceutically acceptable carrier and/or an adjuvant.

公开(公告)号：EP1567188B1

公开(公告)日：2012-07-11

申请号：EP04785951.7

申请日：2004-06-21

申请人： ELI LILLY AND COMPANY

发明人： CHAM, Bill, E. ,  MALTAIS, Jo-Ann, B. ,  BELLOTTI, Marc

IPC分类号： A61K39/00 ,  A61K39/12 ,  C12Q1/70

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K39/215 ,  A61K39/29 ,  A61K47/6901 ,  A61K2039/5252 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/57 ,  C12N2730/10134 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16134 ,  C12N2770/20034

摘要： The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating modified viral particles with reduced infectivity and enhanced antigenicity. The present invention provides for the use of these modified viral particles in the preparation of medicaments for prevention and/or treatment of one or more viral diseases in a patient. The present invention provides vaccine compositions, comprising these modified viral particles with reduced infectivity and enhanced antigenicity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism. The vaccine composition of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and/or one or more types of virus.