公开(公告)号：EP3383431A1

公开(公告)日：2018-10-10

申请号：EP16871589.4

申请日：2016-12-02

申请人： Agenus Inc. ,  Memorial Sloan-Kettering Cancer Center ,  Ludwig Institute for Cancer Research Ltd

发明人： WILSON, Nicholas S. ,  WAIGHT, Jeremy D. ,  RITTER, Gerd ,  TSUJI, Takemasa ,  LEGER, Olivier ,  SEIBERT, Volker ,  SCHAER, David ,  MERGHOUB, Taha ,  UNDERWOOD, Dennis J. ,  GONZALEZ, Ana M. ,  VAN DIJK, Marc

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K16/30

CPC分类号： C07K16/2878 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76

摘要： The present disclosure provides antibodies that specifically bind to human GITR, as well as compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and deactivate, reduce, or inhibit GITR activity. The present disclosure also provides methods for treating autoimmune or inflammatory diseases disorders, by administering an antibody that specifically binds to human GITR and deactivates, reduces, or inhibits GITR activity.

公开(公告)号：EP3383430A1

公开(公告)日：2018-10-10

申请号：EP16871583.7

申请日：2016-12-02

申请人： Agenus Inc. ,  Memorial Sloan-Kettering Cancer Center ,  Ludwig Institute for Cancer Research Ltd

发明人： WILSON, Nicholas S. ,  WAIGHT, Jeremy D. ,  RITTER, Gerd ,  SCHAER, David ,  HIRSCHHORN-CYMERMAN, Daniel ,  MERGHOUB, Taha ,  BREOUS-NYSTROM, Ekaterina V. ,  SEIBERT, Volker ,  TSUJI, Takemasa ,  LEGER, Olivier ,  UNDERWOOD, Dennis J. ,  VAN DIJK, Marc

IPC分类号： A61K39/395 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K16/2827 ,  C07K16/30 ,  C07K2317/30 ,  C07K2317/31 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76

摘要： The present disclosure provides multispecific (e.g., bispecific) antibodies that specifically bind to human GITR and/or human OX40 as well as compositions comprising such antibodies. In a specific aspect, the multispecific antibodies specifically bind to human GITR and OX40 and modulate GITR and/or OX40 activity, e.g., enhance, activate, or induce GITR and/or OX40 activity, or reduce, deactivate, or inhibit GITR and/or OX40 activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering a multispecific antibody that specifically binds to human GITR and/or OX40 and modulates GITR and/or OX40 activity, e.g., enhances, activates, or induces GITR and/or OX40 activity. Also provided are methods for treating autoimmune or inflammatory diseases or disorders, by administering a multispecific antibody that specifically binds to human GITR and/or OX40 and modulates GITR and/or OX40 activity, e.g., reduces, deactivates, or inhibits GITR and/or OX40 activity.

公开(公告)号：EP3148579A1

公开(公告)日：2017-04-05

申请号：EP15729987.6

申请日：2015-05-28

申请人： Agenus Inc. ,  Memorial Sloan Kettering Cancer Center ,  Ludwig Institute for Cancer Research Ltd

发明人： UNDERWOOD, Dennis J. ,  LEGER, Olivier ,  SIEBERT, Volker ,  VAN DIJK, Marc ,  SCHAER, David ,  TSUJI, Takemasa ,  RITTER, Gerd ,  GONZALEZ, Ana M. ,  WILSON, Nicolas S. ,  ZAPPASODI, Roberta ,  MERGHOUB, Taha ,  WOLCHOK, Jedd David

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2878 ,  A61K35/17 ,  A61K2039/507 ,  C07K16/2809 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/502 ,  G01N2333/70578

摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.

摘要翻译： 本公开提供了特异性结合人类糖皮质激素诱导的TNFR家族相关受体（GITR）的抗体和包含此类抗体的组合物。 在具体方面，所述抗体与所述抗体特异性结合人GITR并调节GITR活性，例如增强，激活或诱导GITR活性。 本公开还提供了通过施用特异性结合人GITR并调节GITR活性的抗体（例如增强，激活或诱导GITR活性）来治疗疾病如癌症和感染性疾病的方法。