专利检索 ap:("Agilent Technologies, Inc.") AND inv:"RYAN, Daniel E." 第 1 页

1.

发明公开
GUIDE RNA WITH CHEMICAL MODIFICATIONS 审中-公开

公开(公告)号：EP4400584A3

公开(公告)日：2024-10-16

申请号：EP24165113.2

申请日：2015-12-03

申请人： Agilent Technologies, Inc.

发明人： RYAN, Daniel E. , DELLINGER, Douglas J. , SAMPSON, Jeffrey R. , KAISER, Robert , MYERSON, Joel

IPC分类号： C12N15/113 , C07H21/00 , C12N9/22

摘要： The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.

2.

发明公开
GUIDE RNAS WITH CHEMICAL MODIFICATION FOR PRIME EDITING 审中-实审

公开(公告)号：EP4399294A1

公开(公告)日：2024-07-17

申请号：EP22868381.9

申请日：2022-09-12

申请人： Agilent Technologies, Inc.

发明人： RYAN, Daniel E. , DELLINGER, Douglas J. , KAISER, Robert

IPC分类号： C12N9/22 , C12N15/113 , C12N15/11 , C12N15/62

CPC分类号： C12N9/22 , C12N15/62 , C12N2310/2020170501 , C12N15/102

3.

发明公开
GUIDE RNA WITH CHEMICAL MODIFICATIONS 审中-实审

公开(公告)号：EP4400584A2

公开(公告)日：2024-07-17

申请号：EP24165113.2

申请日：2015-12-03

申请人： Agilent Technologies, Inc.

发明人： RYAN, Daniel E. , DELLINGER, Douglas J. , SAMPSON, Jeffrey R. , KAISER, Robert , MYERSON, Joel

IPC分类号： C12N9/22

CPC分类号： C12N9/22 , C07H21/02 , C12N2310/1020130101 , C12N2310/31220130101 , C12N2310/32320130101 , C12N2310/33320130101 , C12N2310/34620130101 , C12N2310/351720130101 , C12N2320/5120130101 , C12N2320/5320130101 , C12N2330/3120130101 , C12N2310/2020170501 , C12N15/113 , C12N2310/31520130101 , C12N2310/323120130101 , C12N2310/33520130101 , C12N2310/53120130101 , C12N15/111

摘要： The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.

4.

发明公开
CHEMICALLY MODIFIED GUIDE RNAS FOR CRISPR/CAS-MEDIATED GENE REGULATION 审中-公开
标题翻译：用于CRISPR / CAS介导的基因调控的化学修饰的指导RNA

公开(公告)号：EP3280803A1

公开(公告)日：2018-02-14

申请号：EP16720220.9

申请日：2016-04-05

申请人： The Board Of Trustees Of The Leland Stanford Junior University , Agilent Technologies, Inc.

发明人： PORTEUS, Matthew H. , HENDEL, Ayal , CLARK, Joe , BAK, Rasmus O. , RYAN, Daniel E. , DELLINGER, Douglas J. , KAISER, Robert , MYERSON, Joel

IPC分类号： C12N15/10 , C12N15/11

CPC分类号： C12N15/11 , C12N9/22 , C12N9/96 , C12N15/111 , C12N15/907 , C12N2310/10 , C12N2310/20 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/531 , C12N2320/51

摘要： Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using modified single guide RNAs (sgRNAs) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a modified sgRNA to correct a mutation in a target gene associated with the genetic disease.