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公开(公告)号：EP3566706A1
公开(公告)日：2019-11-13
申请号：EP19177845.5
申请日：2014-08-01
发明人： AGRESTA, Samuel, V. , GU, Chong-Hui , SCHENKEIN, David , YANG, Hua , GUO, Liting , TANG, Zhen , WANG, Jianming , ZHANG, Yanfeng , ZHOU, Yan
IPC分类号： A61K31/5377 , A61K31/53 , C07D401/12 , C07D401/14
摘要： Provided are compounds useful for treating cancer and methods of treating cancer, comprising administering to a subject in need thereof a compound described herein.
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公开(公告)号：EP3362070A1
公开(公告)日：2018-08-22
申请号：EP16788866.8
申请日：2016-10-14
发明人： CHOPRA, Vivek, Saroj, Kumar , DIMARTINO,Jorge , KENVIN, Laurie, A. , KNIGHT, Robert, Douglas , MACBETH, Kyle , VISWANADHAN, Krishnan , XU, Qiang , AGRESTA, Samuel, V.
IPC分类号： A61K31/53 , A61K31/7068 , A61K45/06 , A61P35/02 , A61P35/00
CPC分类号： A61K31/53 , A61K31/706 , A61K31/7068 , A61K2300/00 , A61P35/02
摘要： Provided are methods and compositions for treating cancers in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme and a DNA demethylating agent.
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公开(公告)号：EP3200800A1
公开(公告)日：2017-08-09
申请号：EP15778158.4
申请日：2015-09-28
发明人： AGRESTA, Samuel, V.
CPC分类号： A61K31/53 , A61K9/0053 , A61K31/185
摘要： Provided are compounds useful for treating cancer and methods of treating cancer, for example an advanced solid tumor, such as a glioma, or angioimmunoblastic T-cell lymphoma (AITL).
摘要翻译： 提供了用于治疗癌症的化合物和治疗癌症的方法，例如晚期实体瘤如神经胶质瘤或血管免疫母细胞性T细胞淋巴瘤（AITL）。
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公开(公告)号：EP4344703A1
公开(公告)日：2024-04-03
申请号：EP23196616.9
申请日：2016-06-10
发明人： AGRESTA, Samuel, V. , CHEN, Yue , COHEN, Marvin Barry , DANG, Leonard Luan C. , KUNG, Charles , MERICA, Elizabeth A. , SILVER, Bruce Alan , YANG, Hua
IPC分类号： A61K31/4709 , A61K31/496 , C07D215/36 , A61P7/06 , A61K9/00
摘要： Described herein are methods for using compounds that activate pyruvate kinase.
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公开(公告)号：EP3362066A1
公开(公告)日：2018-08-22
申请号：EP16856278.3
申请日：2016-10-14
发明人： AGRESTA, Samuel, V. , VISWANADHAN, Krishnan , DIMARTINO, Jorge , CHOPRA, Vivek Saroj, Kumar , MACBETH, Kyle, J. , KNIGHT, Robert, Douglas , KENVIN, Laurie , XU, Qiang
IPC分类号： A61K31/4439 , C07H19/12 , A61P35/00
CPC分类号： A61K31/706 , A61K31/444 , A61K45/06 , A61P35/02 , A61K2300/00
摘要： Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation using a combination of an inhibitor of a mutant IDH1 enzyme and a DNA demethylating agent.
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公开(公告)号：EP3362065A1
公开(公告)日：2018-08-22
申请号：EP16856274.2
申请日：2016-10-14
发明人： AGRESTA, Samuel, V.
IPC分类号： A61K31/4439 , C07H19/06
CPC分类号： A61K31/444 , A61K31/136 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61P35/02 , C07H15/252 , C07H19/09
摘要： Provided are methods and compositions for treating cancers in patients carrying an IDH1 mutation using a combination of an inhibitor of a mutant IDH1 enzyme and an AML induction and consolidation therapy.
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公开(公告)号：EP3307271A1
公开(公告)日：2018-04-18
申请号：EP16808374.9
申请日：2016-06-10
发明人： AGRESTA, Samuel, V. , CHEN, Yue , COHEN, Marvin, Barry , DANG, Leonard Luan, C. , KUNG, Charles , MERICA, Elizabeth, A. , SILVER, Bruce, Alan , YANG, Hua
IPC分类号： A61K31/4709 , A61K31/496 , C07D215/36
CPC分类号： A61K31/496 , A61P7/06
摘要： Described herein are methods for using compounds that activate pyruvate kinase.
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公开(公告)号：EP3932408A1
公开(公告)日：2022-01-05
申请号：EP21178745.2
申请日：2014-08-01
发明人： AGRESTA, Samuel, V. , GU, Chong-Hui , SCHENKEIN, David , YANG, Hua , TANG, Zhen , WANG, Jianming , ZHANG, Yanfeng , ZHOU, Yan , GUO, Liting
IPC分类号： A61K31/5377 , A61K31/53 , C07D401/12 , C07D401/14 , A61K9/20 , A61K31/444 , A61P19/00 , A61P21/00 , A61P35/00
摘要： Provided are compounds useful for treating cancer and methods of treating cancer, comprising administering to a subject in need thereof a compound described herein.
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公开(公告)号：EP3362057A1
公开(公告)日：2018-08-22
申请号：EP16787982.4
申请日：2016-10-14
发明人： AGRESTA, Samuel, V.
IPC分类号： A61K31/136 , A61K31/53 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61P35/02
CPC分类号： A61K31/53 , A61K31/136 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K2300/00 , A61P35/02
摘要： Provided are methods and compositions for treating AML in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme and an AML induction and consolidation therapy.
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公开(公告)号：EP3027193A2
公开(公告)日：2016-06-08
申请号：EP14832505.3
申请日：2014-08-01
发明人： AGRESTA, Samuel, V. , GU, Chong-Hui , SCHENKEIN, David , YANG, Hua , GUO, Liting , TANG, Zhen , WANG, Jianming , ZHANG, Yanfeng , ZHOU, Yan
IPC分类号： A61K31/5377 , A61K31/53 , C07D401/12
CPC分类号： C07D401/14 , A61K9/2054 , A61K9/2059 , A61K31/444 , A61K31/53 , C07B2200/13
摘要： Provided are isocitrate dehydrogenase 2 (IDH2) inhibitor compounds useful for treating cancer and methods of treating cancer, comprising administering to a subject in need thereof a compound described herein. Also provided are polymorphic forms of the IDH2 inhibitor compounds characterized by X Ray powder diffraction patterns, having improved physicochemical properties that influence in vivo dissolution rate for formulation purposes.
摘要翻译： 提供可用于治疗癌症的化合物和治疗癌症的方法，其包括向有需要的受试者施用本文所述的化合物。
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