公开(公告)号：EP1105120A2

公开(公告)日：2001-06-13

申请号：EP99968010.1

申请日：1999-08-20

申请人： AGOURON PHARMACEUTICALS, INC.

发明人： ANDERSON, Mark, Brian ,  VAZIR, Haresh, N. ,  LUTHIN, David, Robert ,  PADERES, Genevieve, DeGuzman ,  PATHAK, Ved, P. ,  CHRISTIE, Lance, Christopher ,  HONG, Yufeng ,  TOMPKINS, Eileen, Valenzuela ,  LI, Haitao ,  FAUST, James

IPC分类号： A61K31/34 ,  A61K31/505 ,  A61K31/50 ,  C07D405/12 ,  C07D307/68 ,  A61P5/04

CPC分类号： C07D405/12 ,  C07D307/68 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12

摘要： Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

摘要翻译： 描述了能够抑制促性腺激素释放激素作用的非肽GnRH剂。 这些化合物及其药学上可接受的盐，多聚体，前体药物和活性代谢物适用于治疗哺乳动物生殖疾病和类固醇激素依赖性肿瘤以及调节生育力，其中指示促性腺激素释放的抑制。 还描述了合成用于其制备的化合物和中间体的方法。

公开(公告)号：EP1105120B1

公开(公告)日：2005-03-23

申请号：EP99968010.1

申请日：1999-08-20

申请人： AGOURON PHARMACEUTICALS, INC.

发明人： ANDERSON, Mark, Brian ,  VAZIR, Haresh, N. ,  LUTHIN, David, Robert ,  PADERES, Genevieve, DeGuzman ,  PATHAK, Ved, P. ,  CHRISTIE, Lance, Christopher ,  HONG, Yufeng ,  TOMPKINS, Eileen, Valenzuela ,  LI, Haitao ,  FAUST, James

IPC分类号： A61K31/34 ,  A61K31/505 ,  A61K31/50 ,  C07D405/12 ,  C07D307/68 ,  A61P5/04 ,  C07D409/12 ,  C07D417/12

CPC分类号： C07D405/12 ,  C07D307/68 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12

摘要： Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

公开(公告)号：EP1401427A2

公开(公告)日：2004-03-31

申请号：EP02739712.4

申请日：2002-06-05

申请人： Agouron Pharmaceuticals, Inc.

发明人： SUN, Eric, T. ,  ANDERSON, Mark, B. ,  ANDERES, Kenna, Lynn ,  CHRISTIE, Lance, Christopher ,  DO, Quyen-Quyen, Thuy ,  FENG, Jun ,  GOETZEN, Thomas ,  HONG, Yufeng ,  KRAYNOV, Eugenia, Anatolievna ,  LI, Haitao ,  LUTHIN, David, Robert ,  PADERES, Genevieve, D. ,  PATHAK, Ved, P. ,  RAJAPAKSE, Ranjan, Jagath ,  SHACKELFORD, Scott ,  TOMPKINS, Eileen, Valenzuela ,  TRUESDALE, Larry, Kenneth ,  VAZIR, Haresh

IPC分类号： A61K31/341 ,  A61K31/443 ,  A61K31/497 ,  C07D307/58 ,  C07D405/10

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D307/68 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D471/04

摘要： Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.