公开(公告)号：EP1627869B1

公开(公告)日：2012-05-02

申请号：EP04770804.5

申请日：2004-05-20

申请人： AJINOMOTO CO., INC.

发明人： NAKAGAWA, Tadakiyo, c/o AJINOMOTO CO., INC. ,  SUZUKI, Tamotsu, c/o AJINOMOTO CO., INC. ,  TAKENAKA, Kaoru, c/o AJINOMOTO CO., INC. ,  FUJITA, Shinichi, c/o AJINOMOTO CO., INC. ,  YAMADA, Youji, c/o AJINOMOTO CO., INC. ,  SHIMA, Yoichiro, c/o AJINOMOTO CO., INC. ,  OKUZUMI, Tatsuya, c/o AJINOMOTO CO., INC. ,  YOSHIMURA, Toshihiko, c/o AJINOMOTO CO., INC. ,  YOSHIDA, Masanao, c/o AJINOMOTO CO., INC. ,  MURATA, Masahiro, c/o AJINOMOTO CO., INC.

IPC分类号： C07D401/12 ,  C07D215/38 ,  C07C311/16 ,  C07C317/40 ,  C07D277/64 ,  C07D417/14 ,  C07D401/14 ,  C07D401/04 ,  C07D413/14 ,  C07D413/12 ,  A61P29/00 ,  A61K31/445

CPC分类号： C07D401/04 ,  C07C237/04 ,  C07D401/14

摘要： An amide derivative represented by the formula (I): [wherein A represents cycloalkyl, aryl, or heteroaryl; X represents nitrogen or CR17; Y represents NRa, -(CRbRb')m-, etc.; m is 0 to 4; R1 to R17 may be the same or different and each represents hydrogen, halogeno, cyano, nitro, carboxy, formyl, hydroxy, ammonium, optionally substituted alkyl, ZR18, etc.; Z represents -O-, -S(O)p-, -S(O)pO-, -NH-, -NR19-, etc.; and R1 may be bonded to R2 to form a ring] or a pharmaceutically acceptable salt, hydrate, or solvate of the derivative. They are used in medical applications such as anti-inflammation and analgesia.

公开(公告)号：EP1477482B1

公开(公告)日：2010-04-14

申请号：EP03705344.4

申请日：2003-02-20

申请人： Ajinomoto Co., Inc.

发明人： SAGI, Kazuyuki, c/o AJINOMOTO CO., INC. ,  IZAWA, Hiroyuki, c/o AJINOMOTO CO., INC. ,  CHIBA, Akira, c/o AJINOMOTO CO., INC. ,  OKUZUMI, Tatsuya, c/o AJINOMOTO CO., INC. ,  YOSHIMURA, Toshihiko, c/o AJINOMOTO CO., INC. ,  TANAKA, Yuji, c/o AJINOMOTO CO., INC. ,  ONO, Miho, c/o AJINOMOTO CO., INC. ,  MURATA, Masahiro, c/o AJINOMOTO CO., INC.

IPC分类号： C07D239/96 ,  C07D239/52 ,  C07D239/80 ,  C07D285/16 ,  C07D285/32 ,  C07D487/04 ,  C07D405/12 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61P29/00

CPC分类号： C07D265/26 ,  C07D239/54 ,  C07D239/80 ,  C07D239/96 ,  C07D253/04 ,  C07D285/16 ,  C07D285/24 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04 ,  C07D487/04

摘要： The following phenylalanine derivative having an α4 integrin inhibitory effect, its analogs and remedies for various diseases in which α4 integrin participates.

公开(公告)号：EP1477482A1

公开(公告)日：2004-11-17

申请号：EP03705344.4

申请日：2003-02-20

申请人： Ajinomoto Co., Inc.

发明人： SAGI, Kazuyuki, c/o AJINOMOTO CO., INC. ,  IZAWA, Hiroyuki, c/o AJINOMOTO CO., INC. ,  CHIBA, Akira, c/o AJINOMOTO CO., INC. ,  OKUZUMI, Tatsuya, c/o AJINOMOTO CO., INC. ,  YOSHIMURA, Toshihiko, c/o AJINOMOTO CO., INC. ,  TANAKA, Yuji, c/o AJINOMOTO CO., INC. ,  ONO, Miho, c/o AJINOMOTO CO., INC. ,  MURATA, Masahiro, c/o AJINOMOTO CO., INC.

IPC分类号： C07D239/96 ,  C07D239/52 ,  C07D239/78 ,  C07D239/80 ,  C07D285/16 ,  C07D285/32 ,  C07D487/04 ,  C07D405/12 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5415

CPC分类号： C07D265/26 ,  C07D239/54 ,  C07D239/80 ,  C07D239/96 ,  C07D253/04 ,  C07D285/16 ,  C07D285/24 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04 ,  C07D487/04

摘要： The present invention relates to the following phenylalanine derivatives or analogues thereof having an antagonistic activity to α4 integrin and therapeutic agents for various diseases concerning α4 integrin.

摘要翻译： 本发明涉及对α4整联蛋白具有拮抗作用的以下苯丙氨酸衍生物或其类似物以及涉及α4整联蛋白的各种疾病的治疗剂。