公开(公告)号：EP2913331B8

公开(公告)日：2018-10-31

申请号：EP13849469.5

申请日：2013-10-21

申请人： Nissan Chemical Corporation

发明人： KAKIUCHI, Nobuyuki ,  HIRASADA. Kazuki ,  YAMAGUCHI, Hiroki ,  TSUDA, Yutaro

IPC分类号： C07D405/14

CPC分类号： C07D405/14 ,  C07D251/34 ,  C07D253/04

摘要： There is provided a method for producing an epoxy compound having an epoxy ring bonded to a triazinetrione ring via a long chain alkylene group, an olefin compound having a specific structure is used to efficiently obtain an epoxy compound of which an olefin moiety is epoxidized in high yield. A method for producing an epoxy compound of Formula (2): comprising reacting a triolefin compound of the following Formula (1): (In the above-mentioned Formulae, R 1 to R 9 are each independently a hydrogen atom or a methyl group; and n1 to n3 are each independently an integer of 1 to 4) with hydrogen peroxide, a nitrile compound, and an alkaline substance in a solvent. The nitrile compound is an aliphatic nitrile compound or an aromatic nitrile compound. The alkaline substance is phosphate, carbonate, or an alkaline metal hydroxide.

公开(公告)号：EP3164387A1

公开(公告)日：2017-05-10

申请号：EP15731966.6

申请日：2015-06-30

申请人： Bayer CropScience Aktiengesellschaft

发明人： MOSRIN, Marc ,  JAKOBI, Harald ,  DIETRICH, Hansjörg ,  GATZWEILER, Elmar ,  ROSINGER, Christopher Hugh ,  SCHMUTZLER, Dirk

IPC分类号： C07D213/57 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D241/12 ,  C07D251/20 ,  C07D263/32 ,  C07D277/30 ,  C07D307/54 ,  C07D333/24 ,  A01N43/08 ,  A01N43/10 ,  A01N43/28 ,  A01N43/40 ,  A01N43/50

CPC分类号： C07D333/28 ,  A01N43/08 ,  A01N43/10 ,  A01N43/40 ,  A01N43/48 ,  A01N43/50 ,  A01N43/54 ,  A01N43/58 ,  A01N43/60 ,  A01N43/66 ,  A01N43/707 ,  A01N43/76 ,  A01N43/78 ,  C07D213/57 ,  C07D213/61 ,  C07D231/12 ,  C07D231/16 ,  C07D233/64 ,  C07D233/68 ,  C07D237/08 ,  C07D237/12 ,  C07D239/26 ,  C07D239/30 ,  C07D241/12 ,  C07D241/16 ,  C07D251/20 ,  C07D253/04 ,  C07D253/065 ,  C07D253/07 ,  C07D253/075 ,  C07D263/32 ,  C07D263/34 ,  C07D277/30 ,  C07D277/32 ,  C07D307/54 ,  C07D307/56 ,  C07D333/24

摘要： Primarily, the present invention relates to compounds of the formula (I) defined below and to the use thereof as herbicides, in particular for controlling broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants. The present invention further relates to herbicidal or crop growth-regulating compositions comprising one or more of the compounds of the formula (I). Moreover, the present invention relates to processes for preparing the compounds of the formula (I).

摘要翻译： 主要地，本发明涉及下面定义的式（I）的化合物及其用作除草剂，特别是用于在有用植物作物和/或作为植物生长调节控制阔叶杂草和/或杂草用于影响 有用植物作物的生长。 因此，本发明涉及除草或植物生长调节组合物，包含式（I）的一种或多种化合物。 更过地，本发明涉及用于制备式（I）的化合物。

公开(公告)号：EP1919867B1

公开(公告)日：2011-08-17

申请号：EP06813923.7

申请日：2006-08-29

申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION

发明人： MACDONALD, Timothy, L. ,  NADLER, Jerry, L. ,  CUI, Peng

IPC分类号： C07D209/08 ,  C07D209/80 ,  C07D221/08 ,  C07D223/22

CPC分类号： A61K31/538 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4196 ,  A61K31/495 ,  A61K31/502 ,  A61K31/53 ,  C07C215/68 ,  C07C219/32 ,  C07D209/08 ,  C07D209/80 ,  C07D221/08 ,  C07D223/22 ,  C07D241/08 ,  C07D241/18 ,  C07D249/12 ,  C07D253/04 ,  C07D265/26 ,  C07D265/36 ,  C07D265/38 ,  C07D275/04 ,  C07D279/22 ,  C07D487/04

摘要： The present invention provides analogs of formula (I) of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF. The compounds (II) are used to treat diabetes, inflammatory and autoimmune conditions. wherein R1 is hydrogen or a group having the formula -C(=O)R3, wherein R is lower alkyl, and R2 is selected from the group consisting of.

公开(公告)号：EP1856063A1

公开(公告)日：2007-11-21

申请号：EP06727254.2

申请日：2006-02-21

申请人： Ranbaxy Laboratories Limited

发明人： PALLE, Venkata, P. ,  SATTIGERI, Viswajanani, Jitendra ,  KHERA, Manoj, Kumar ,  VOLETI, Sreedhara, Rao, Apartment No. 201 ,  RAY, Abhijit ,  DASTIDAR, Sunanda, G.

IPC分类号： C07D249/18 ,  C07D209/48 ,  C07D237/32 ,  C07D209/12 ,  C07D239/54 ,  C07D213/64 ,  C07D265/28 ,  C07D211/88 ,  C07D207/40 ,  C07D263/58 ,  C07D239/96 ,  C07D471/04 ,  C07D401/10 ,  C07D403/10 ,  A61P11/06

CPC分类号： C07D253/04 ,  C07C59/54 ,  C07C233/51 ,  C07C271/22 ,  C07C311/19 ,  C07D209/18 ,  C07D209/46 ,  C07D209/48 ,  C07D211/88 ,  C07D221/20 ,  C07D237/32 ,  C07D239/54 ,  C07D239/96 ,  C07D253/08 ,  C07D263/58 ,  C07D265/36 ,  C07D401/06 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10

摘要： The present invention relates to C ompounds having the structure of Formula I: wherein n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR4R5, -NHC(=Y)R4, - NHC(=Y)NR5Rχ, -NHC(=O)OR4, -NHSO2R4, C(=Y)NR4R5, C(=O)OR6 [wherein Y is oxygen or sulphur], OR5, -O(C=O)NR4R5, O-acyl, S(O)mR4, -SO2N(R4)2, cyano, amidino or guanidino [wherein R4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R5 is hydrogen or R4; Rx is R4 or -SO2N(R4)2 and R6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R3 is hydrogen, fluorine, alkyl, cycloalkylalkyl or aralkyl; A is OH, OR4, -OC(=O)NR4R5, O-acyl, NH2, NR4R5, -NHC(=Y)R4, -NHC(=Y)NR5Rx, - NHC(=O)OR4, -NHSO2R4, and to processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over-activation of an matrix metalloproteinase, using the compounds.

公开(公告)号：EP1181280A1

公开(公告)日：2002-02-27

申请号：EP00927048.9

申请日：2000-04-26

申请人： Bayer Aktiengesellschaft ,  Müller, Klaus-Helmut

发明人： LEHR, Stefan ,  SCHALLNER, Otto ,  SCHWARZ, Hans-Georg ,  WROBLOWSKY, Heinz-Jürgen ,  DREWES, Mark, Wilhelm ,  FEUCHT, Dieter ,  PONTZEN, Rolf ,  WETCHOLOWSKY, Ingo ,  MULLER, Klaus-Helmut

IPC分类号： C07D233/32 ,  C07D233/42 ,  C07D239/10 ,  C07D249/08 ,  A01N43/50 ,  A01N43/54 ,  A01N43/653

CPC分类号： C07D209/48 ,  A01N43/653 ,  C07D213/64 ,  C07D231/20 ,  C07D233/70 ,  C07D237/32 ,  C07D239/10 ,  C07D249/12 ,  C07D249/14 ,  C07D253/04 ,  C07D263/58 ,  C07D275/06 ,  C07D285/13 ,  C07D471/04 ,  C07D487/04

摘要： The invention relates to novel substituted benzoyl ketones of formula (I), wherein n represents 0, 1, 2 or 3; A represents a simple bond or alkanediyl (alkylene); R1 represents hydrogen or optionally substituted alkyl or cycloalkyl; R2 represents hydrogen, cyano, carbamoyl, halogen, or optionally substituted alkyl, alkoxy, alkoxycarbonyl, alkylthio, alkylsulfinyl or alkylsulfonyl; R3 represents hydrogen, nitro, cyano, carboxy, carbamoyl, thiocarbamoyl, halogen or optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino or dialkylaminosulfonyl; R4 represents nitro, cyano, carboxy, carbamoyl, thiocarbamoyl, halogen or optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino or dialkylaminosulfonyl; and Z represents an optionally substituted 4 to 12-membered, saturated or unsaturated, monocyclic or bicyclic, heterocyclic grouping containing 1 to 4 hetero atoms (up to 4 nitrogen atoms and optionally, - alternatively or additionally - an oxygen atom or a sulphur atom, or an SO¿2? grouping), which also contains one to three oxo-groups (C=O) and/or thioxo-groups (C=S) as constituents of the heterocycle. The invention also relates to methods for producing the inventive substituted benzoyl ketones and to their use as herbicides.

公开(公告)号：EP0923530A1

公开(公告)日：1999-06-23

申请号：EP97926455.0

申请日：1997-05-12

申请人： Bayer Corporation

发明人： VAN ZANDT, Michael, C. ,  BRITTELLI, David, R. ,  DIXON, Brian, R.

IPC分类号： A61K31 ,  A61P1 ,  A61P3 ,  A61P7 ,  A61P9 ,  A61P15 ,  A61P25 ,  A61P27 ,  A61P29 ,  A61P31 ,  A61P35 ,  A61P43 ,  C07C59 ,  C07D231 ,  C07D233 ,  C07D235 ,  C07D237 ,  C07D239 ,  C07D243 ,  C07D253 ,  C07D263 ,  C07D275 ,  C07D277 ,  C07D295

CPC分类号： C07D263/44 ,  C07C59/90 ,  C07D237/32 ,  C07D243/24 ,  C07D253/04 ,  C07D263/58 ,  C07D275/04 ,  C07D277/34

摘要： Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have generalized formula (1) wherein r is 0-2, T is selected from (a) and (b) and R40 is a mono- or bi-heterocyclic structure. These compounds are useful for inhibiting matrix metalloproteases and, therefore, combating conditions to which MMP's contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic disease, dystrophobic epidermolysis, bullosa, conditions leading to inflammatory responses, osteopenias mediated by MMP activity, tempero mandibular joint disease, demyelating diseases of the nervous system, tumor metastasis of degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from athrosclerotic plaque rupture. The present invention also provides pharmaceutical compositions and methods for treating such conditions.

摘要翻译： 介绍了基质金属蛋白酶抑制化合物，其药物组合物和使用这些化合物的疾病治疗方法。 本发明化合物具有通式（1），其中r为0-2，T选自（a）和（b），R40为单或双杂环结构。 这些化合物可用于抑制基质金属蛋白酶，因此可用于抵抗MMP引起的疾病，例如骨关节炎，类风湿性关节炎，脓毒性关节炎，牙周病，角膜溃疡，蛋白尿，动脉瘤性主动脉疾病，营养不良性表皮松解症，大疱，导致炎症的病症 反应，由MMP活性介导的骨质疏松症，下颌关节病，神经系统的脱膜疾病，创伤性关节损伤后退行性软骨损伤的肿瘤转移，以及动脉粥样硬化斑块破裂引起的冠状动脉血栓形成。 本发明还提供了用于治疗这些病症的药物组合物和方法。

公开(公告)号：EP4368612A1

公开(公告)日：2024-05-15

申请号：EP22833648.3

申请日：2022-06-29

申请人： Samsung Display Co., Ltd. ,  Dongjin Semichem Co., Ltd.

发明人： HAM, Ho Wan ,  AN, Hyun Cheol ,  KIM, Hee Joo ,  KIM, Dong Jun ,  LEE, Dong Hyun ,  ANN, Ja Eun ,  KWON, Dong Yuel ,  LEE, Sung Kyu ,  CHO, Ill Hun ,  LEE, Bo Ra ,  PARK, Yeong Rong ,  OH, Il Soo ,  LEE, Dae Woong ,  IM, Hyeon Jeong

IPC分类号： C07D213/81 ,  C07D241/26 ,  C07D239/26 ,  C07D237/08 ,  C07D255/02 ,  C07D251/12 ,  C07D253/07 ,  C07D253/04 ,  C07D257/08 ,  C07D401/14

CPC分类号： C07D401/14 ,  C07D237/08 ,  C07D255/02 ,  C07D239/26 ,  C07D251/12 ,  C07D253/04 ,  C07D257/08 ,  C07D241/26 ,  C07D253/07 ,  C07D213/81

摘要： A novel compound for a capping layer, and an organic light-emitting device containing the same are proposed.

公开(公告)号：EP2325169A9

公开(公告)日：2012-03-21

申请号：EP10012734.9

申请日：2006-08-29

申请人： University Of Virginia Patent Foundation

发明人： Macdonald, Timothy, L. ,  Nadler, Jerry, L. ,  Cui, Peng

IPC分类号： C07D209/08 ,  C07D209/80 ,  C07D221/08 ,  C07D223/22 ,  C07D241/08 ,  C07D241/18 ,  C07D249/12 ,  C07D253/04 ,  C07D265/26 ,  C07D265/36 ,  C07D265/38 ,  C07D279/22 ,  C07D275/04 ,  C07D487/04 ,  C07C215/16 ,  A61K31/395 ,  A61K31/40 ,  A61K31/496 ,  A61P3/10 ,  A61P29/00 ,  A61P37/00

CPC分类号： A61K31/538 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4196 ,  A61K31/495 ,  A61K31/502 ,  A61K31/53 ,  C07C215/68 ,  C07C219/32 ,  C07D209/08 ,  C07D209/80 ,  C07D221/08 ,  C07D223/22 ,  C07D241/08 ,  C07D241/18 ,  C07D249/12 ,  C07D253/04 ,  C07D265/26 ,  C07D265/36 ,  C07D265/38 ,  C07D275/04 ,  C07D279/22 ,  C07D487/04

摘要： The present invention provides analogs of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF.

公开(公告)号：EP1919867A2

公开(公告)日：2008-05-14

申请号：EP06813923.7

申请日：2006-08-29

申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION

发明人： MACDONALD, Timothy, L. ,  NADLER, Jerry, L. ,  CUI, Peng

IPC分类号： C07D209/08 ,  C07D209/80 ,  C07D221/08 ,  C07D223/22

CPC分类号： A61K31/538 ,  A61K31/404 ,  A61K31/405 ,  A61K31/4196 ,  A61K31/495 ,  A61K31/502 ,  A61K31/53 ,  C07C215/68 ,  C07C219/32 ,  C07D209/08 ,  C07D209/80 ,  C07D221/08 ,  C07D223/22 ,  C07D241/08 ,  C07D241/18 ,  C07D249/12 ,  C07D253/04 ,  C07D265/26 ,  C07D265/36 ,  C07D265/38 ,  C07D275/04 ,  C07D279/22 ,  C07D487/04

摘要： The present invention provides analogs of formula (I) of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF. The compounds (II) are used to treat diabetes, inflammatory and autoimmune conditions. wherein R1 is hydrogen or a group having the formula -C(=O)R3, wherein R is lower alkyl, and R2 is selected from the group consisting of.

公开(公告)号：EP0923529A1

公开(公告)日：1999-06-23

申请号：EP97923625.0

申请日：1997-05-12

申请人： Bayer Corporation

发明人： KLUENDER, Harold, C., E. ,  DIXON, Brian, R. ,  BRITTELLI, David, R.

IPC分类号： C12N9 ,  A61K31 ,  A61P1 ,  A61P7 ,  A61P13 ,  A61P15 ,  A61P19 ,  A61P21 ,  A61P27 ,  A61P29 ,  A61P35 ,  A61P43 ,  C07C59 ,  C07D209 ,  C07D237 ,  C07D253 ,  C07D263 ,  C07D275 ,  C07D277

CPC分类号： C07D209/48 ,  C07C59/84 ,  C07C59/90 ,  C07D237/32 ,  C07D253/04

摘要： Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have generalized formula (I) wherein R1 represents C¿6?-C12 alkyl; C5-C12 alkoxy; C5-C12 alkylthio; a polyether of formula R?2O(C¿2H4O)a- in which a is 1 or 2 and R2 is C1-C5 alkyl, phenyl, or benzyl; and substituted alkynyl of formula R3(CH2)b-C C-; in which b is 1-10 and R3 is H-, HO-, or R4O- in which R4 is C1-C3 alkyl, phenyl, or benzyl. The alkyl, phenyl, and benzyl portions of R1 may bear at least one pharmaceutically-acceptable substituent. The subscript n is 2-4. R5 represents phenyl; imidoyl of 4-12 carbon atoms; (3H)-benzo-1,2,3-triazin-4-on-3-yl; N-saccharinyl; (2H)-phthalazin-1-on-2-yl; 2-benzoxazolin-2-on-3-yl; 5,5-dimethyloxazolidine-2,4-dion-3-yl; and thiazolidine-2,4-dion-3-yl; with the phenyl and benzo portions of R5 permissibly bearing at least one pharmaceutically-acceptable substituent. Pharmaceutically acceptable salts of these materials are also included.