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公开(公告)号：EP0582338A3
公开(公告)日：1995-08-23
申请号：EP93202204.9
申请日：1993-07-26
申请人： Akzo Nobel N.V.
发明人： Hamersma, Johannes Antonius Maria , Orlemans, Everardus Otto Maria , Rewinkel, Johannes Bernardus Maria
CPC分类号： C07J51/00 , C07J21/00 , C07J21/006 , C07J31/006 , C07J41/0016 , C07J41/0083 , C07J41/0094 , C07J43/003 , C07J53/002 , C07J71/001 , C07J71/0015
摘要： The invention relates to a steroid derivative which steroidal skeleton is bound at carbon atom 17 to a spiromethylene ring of the formula:
wherein R a and R b are independently selected from the group consisting of hydrogen, methyl, and halogen; m is 1 or 2; and the asterisk denotes carbon atom 2 of the spiromethylene ring which is carbon atom 17 (or carbon atom 17a of a homosteroid skeleton) of the steroid. The steroids have progestational or antiprogestational activity.-
公开(公告)号：EP0582338B1
公开(公告)日：1999-10-20
申请号：EP93202204.9
申请日：1993-07-26
申请人： Akzo Nobel N.V.
发明人： Hamersma, Johannes Antonius Maria , Orlemans, Everardus Otto Maria , Rewinkel, Johannes Bernardus Maria
CPC分类号： C07J51/00 , C07J21/00 , C07J21/006 , C07J31/006 , C07J41/0016 , C07J41/0083 , C07J41/0094 , C07J43/003 , C07J53/002 , C07J71/001 , C07J71/0015
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公开(公告)号：EP0582338A2
公开(公告)日：1994-02-09
申请号：EP93202204.9
申请日：1993-07-26
申请人： Akzo Nobel N.V.
发明人： Hamersma, Johannes Antonius Maria , Orlemans, Everardus Otto Maria , Rewinkel, Johannes Bernardus Maria
CPC分类号： C07J51/00 , C07J21/00 , C07J21/006 , C07J31/006 , C07J41/0016 , C07J41/0083 , C07J41/0094 , C07J43/003 , C07J53/002 , C07J71/001 , C07J71/0015
摘要： The invention relates to a steroid derivative which steroidal skeleton is bound at carbon atom 17 to a spiromethylene ring of the formula:
wherein R a and R b are independently selected from the group consisting of hydrogen, methyl, and halogen; m is 1 or 2; and the asterisk denotes carbon atom 2 of the spiromethylene ring which is carbon atom 17 (or carbon atom 17a of a homosteroid skeleton) of the steroid. The steroids have progestational or antiprogestational activity.摘要翻译： 本发明涉及类固醇衍生物，其类固醇骨架在碳原子17处键合到式：CHEM的螺甲烯环，其中R a和R b独立地选自氢，甲基和卤素; m为1或2; 并且星号表示作为类固醇的碳原子17（或类固醇骨架的碳原子17α）的spiromethylene环的碳原子2。 类固醇具有促孕或抗雌激素活性。
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公开(公告)号：EP0549041B1
公开(公告)日：1995-10-11
申请号：EP92203923.5
申请日：1992-12-15
申请人： Akzo Nobel N.V.
发明人： Hamersma, Johannes Antonius Maria , Orlemans, Everardus Otto Maria , Rewinkel, Johannes, Bernadus, Maria
CPC分类号： C07J31/006 , C07J21/00 , C07J41/0083
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公开(公告)号：EP0549041A1
公开(公告)日：1993-06-30
申请号：EP92203923.5
申请日：1992-12-15
申请人： Akzo Nobel N.V.
发明人： Hamersma, Johannes Antonius Maria , Orlemans, Everardus Otto Maria , Rewinkel, Johannes, Bernadus, Maria
CPC分类号： C07J31/006 , C07J21/00 , C07J41/0083
摘要： The invention relates to an antiprogestin 17-spirofuran-3'-ylidene steroid having the formula
wherein
R₁ is NR₂R₃, lower acyl, OH, SH, O-lower alkyl or S(O) n -lower alkyl wherein n is 0-2;
R₂ and R₃ are independently selected from hydrogen and lower alkyl;
R₄ is hydrogen or lower alkyl;
R₅ is O, (H,H), (H,OH), (H,O-lower acyl), or NOH;
R₆ and R₇ are both hydrogen, or one is hydrogen and the other lower alkyl; and
the twitched line represents an α or β bond.摘要翻译： 本发明涉及具有式CHEM的抗孕激素17-螺呋喃-3'-亚基类固醇，其中R 1为NR 2 R 3，低级酰基，OH，SH，O-低级烷基或S（O）n-低级烷基，其中n为0 -2; R2和R3独立地选自氢和低级烷基; R4是氢或低级烷基; R5是O，（H，H），（H，OH），（H，O-低级酰基）或NOH; R6和R7都是氢，或一个是氢，另一个是低级烷基; 抽搐线表示α或β键。 ñ
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