公开(公告)号：EP1974738A3

公开(公告)日：2008-12-17

申请号：EP08157330.5

申请日：2001-02-26

申请人： Alcon, Inc. ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： Clark, Abbot F. ,  Fingert, John ,  McNatt, Loretta ,  Stone, Edwin M. ,  Wang, Wan-Heng

IPC分类号： C12Q1/68 ,  A61K38/00 ,  A61K31/70 ,  A61K39/395 ,  A01K67/027 ,  C12N15/00 ,  A61P27/06 ,  C12N9/00 ,  C07K14/47

CPC分类号： G01N33/5091 ,  A61K38/00 ,  C07K14/47 ,  C12N9/12 ,  C12Q1/485 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/6893 ,  G01N2800/168

摘要： This invention provides methods and compositions for diagnosing and treating glaucoma based on determining the level of a Frizzle Related Protein (FRP), a component of the wingless (Wnt) signaling pathway. The method can include the detection of a genetic lesion like polymorphic allele (e.g. FRP promoter, ...) for diagnosing glaucoma. This invention also discloses the use of transgenic animals for the study of glaucoma (screening for therapeutics, animal disease model, ...).

公开(公告)号：EP1974738A2

公开(公告)日：2008-10-01

申请号：EP08157330.5

申请日：2001-02-26

申请人： Alcon, Inc. ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： Clark, Abbot F. ,  Fingert, John ,  McNatt, Loretta ,  Stone, Edwin M. ,  Wang, Wan-Heng

IPC分类号： A61K38/00 ,  A61K39/395 ,  A01K67/027 ,  C12N15/00 ,  A61P27/06 ,  C12N9/00 ,  C07K14/47 ,  C12Q1/68

CPC分类号： G01N33/5091 ,  A61K38/00 ,  C07K14/47 ,  C12N9/12 ,  C12Q1/485 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5041 ,  G01N33/5044 ,  G01N33/6893 ,  G01N2800/168

摘要： This invention provides methods and compositions for diagnosing and treating glaucoma based on determining the level of a Frizzle Related Protein (FRP), a component of the wingless (Wnt) signaling pathway. The method can include the detection of a genetic lesion like polymorphic allele (e.g. FRP promoter, ...) for diagnosing glaucoma. This invention also discloses the use of transgenic animals for the study of glaucoma (screening for therapeutics, animal disease model, ...).

摘要翻译： 本发明提供了用于诊断和治疗青光眼的方法和组合物，所述方法和组合物基于确定无翅（Wnt）信号通路的组分的卷曲相关蛋白（FRP）的水平。 该方法可以包括用于诊断青光眼的遗传病变如多态等位基因（例如FRP启动子，...）的检测。 本发明还公开了使用转基因动物研究青光眼（筛选治疗学，动物疾病模型，...）。