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    DIAGNOSTIC METHODS FOR GLAUCOMA
    5.
    发明公开
    DIAGNOSTIC METHODS FOR GLAUCOMA 审中-公开
    DIAGNOSEVERFAHRENFÜRGRÜNENSTAR

    公开(公告)号：EP2558862A1

    公开(公告)日：2013-02-20

    申请号：EP11714916.1

    申请日：2011-04-13

    申请人： M-Lab AG

    发明人： GRUS, Franz ,  BOEHM, Nils ,  PFEIFFER, Norbert ,  BELL, Katharina

    IPC分类号： G01N33/564

    CPC分类号： G01N33/6893 ,  G01N2800/168

    摘要： The invention concerns a first diagnostic method for glaucoma based on an analysis of autoimmune reactivity in body fluids against at least one sample of at least partially purified ocular antigens, wherein the autoimmune reactivity against individual antigens is measured and transformed into a glaucoma score to determine the diagnostic result. Further aspects of the invention include antigen carrying elements carrying at least one sample of the at least partially purified ocular antigens and kits for diagnosis of glaucoma. Further aspects include methods of collecting a body fluid such as tears for the use in the diagnostic method for glaucoma. Yet further aspects include ocular antigens serving as diagnostic markers and/or for preparing pharmaceutical compositions for treatment of glaucoma. The invention further concerns a second diagnostic method for glaucoma comprising the steps of a) providing an in vitro culture of cells; b) incubating a body fluid from a test individual with the in vitro culture of cells or incubating components, which are fractionated from the body fluid or from a body specimen of the test individual with the in vitro culture of cells; c) analyzing protein expression of the cells and/or analyzing the viability of the cells after treatment according to step b); and d) comparing the results of the analysis in step c) with standard data to determine a diagnostic result.

    摘要翻译： 本发明涉及基于对至少一种部分纯化的眼部抗原的至少一种样品的体液中的自身免疫反应性的分析的青光眼的第一诊断方法，其中测量针对个体抗原的自身免疫反应性并将其转化为青光眼评分，以确定 诊断结果。 本发明的其它方面包括携带至少部分纯化的眼部抗原的至少一个样品的抗原携带元件和用于诊断青光眼的试剂盒。 其它方面包括收集体液如泪液的方法用于青光眼的诊断方法。 另外的方面包括用作诊断标记的眼部抗原和/或用于制备用于治疗青光眼的药物组合物。 本发明还涉及青光眼的第二诊断方法，包括以下步骤：a）提供细胞的体外培养; b）将来自测试个体的体液与体外培养的细胞或孵育组分一起孵育，所述体液培养物通过细胞的体外培养从体液或来自测试个体的体标本分馏; c）根据步骤b）分析细胞的蛋白质表达和/或分析治疗后细胞的存活力; 以及d）将步骤c）中的分析结果与标准数据进行比较以确定诊断结果。

    INTRAOCULAR PRESSURE-REGULATED EARLY GENES AND USES THEREOF
    7.
    发明公开
    INTRAOCULAR PRESSURE-REGULATED EARLY GENES AND USES THEREOF 有权
    早期基因调控之间的眼压及其用途

    公开(公告)号：EP1957986A2

    公开(公告)日：2008-08-20

    申请号：EP06844496.7

    申请日：2006-11-22

    申请人： McGill University

    发明人： SARAGOVI, H., Uri

    IPC分类号： G01N33/574 ,  C07K16/30 ,  C12N15/12 ,  C07K14/705 ,  A61K31/7088

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/30 ,  C07K2317/76 ,  G01N33/5308 ,  G01N2800/168

    摘要： The present invention relates to methods to treat glaucoma and glaucoma-related conditions through the regulation of changes in gene expression that are mediated by high intraocular pressure or alpha2 macroglobulin administration. Glaucoma, retinal ganglion cell (RGC) death and chronic ocular hypertension are treated using pharmaceutical compositions which comprise substances that inhibit the expression or activity of intraocular pressure-regulated early genes (IPREGs) or their gene products that are up-regulated by high intraocular pressure or alpha2 macroglobulin administration and/or which increase the expression or activity of IPREGs or their gene products that are down-regulated by high intraocular pressure or alpha2 macroglobulin administration. The invention also relates to methods of identifying an IPREG and methods to test for chronic ocular degeneration and the onset of RGC stress in an individual by measuring the expression level of IPREG proteins.

    DIAGNOSTIC METHODS FOR GLAUCOMA
    9.
    发明授权
    DIAGNOSTIC METHODS FOR GLAUCOMA 有权

    公开(公告)号：EP2558862B1

    公开(公告)日：2018-11-21

    申请号：EP11714916.1

    申请日：2011-04-13

    申请人： m-lab GmbH

    发明人： GRUS, Franz ,  BOEHM, Nils ,  PFEIFFER, Norbert ,  BELL, Katharina

    IPC分类号： G01N33/564

    CPC分类号： G01N33/6893 ,  G01N2800/168

    摘要： The invention concerns a first diagnostic method for glaucoma based on an analysis of autoimmune reactivity in body fluids against at least one sample of at least partially purified ocular antigens, wherein the autoimmune reactivity against individual antigens is measured and transformed into a glaucoma score to determine the diagnostic result. Further aspects of the invention include antigen carrying elements carrying at least one sample of the at least partially purified ocular antigens and kits for diagnosis of glaucoma. Further aspects include methods of collecting a body fluid such as tears for the use in the diagnostic method for glaucoma. Yet further aspects include ocular antigens serving as diagnostic markers and/or for preparing pharmaceutical compositions for treatment of glaucoma. The invention further concerns a second diagnostic method for glaucoma comprising the steps of a) providing an in vitro culture of cells; b) incubating a body fluid from a test individual with the in vitro culture of cells or incubating components, which are fractionated from the body fluid or from a body specimen of the test individual with the in vitro culture of cells; c) analyzing protein expression of the cells and/or analyzing the viability of the cells after treatment according to step b); and d) comparing the results of the analysis in step c) with standard data to determine a diagnostic result.