公开(公告)号：EP3283517A2

公开(公告)日：2018-02-21

申请号：EP16780954.0

申请日：2016-04-15

申请人： Alder Biopharmaceuticals, Inc.

发明人： ALLISON, Daniel, S. ,  OJALA, Ethan Wayne ,  FAN, Pei ,  SMITH, Jeffrey, T.L. ,  LATHAM, John ,  KARASEK, Charlie ,  MULLIGAN, Jenny ,  SCALLEY-KIM, Michelle ,  STEWART, Erica ,  HENDRIX, Katherine Lee ,  RUBIN, Vanessa Lisbeth ,  BILLGREN, Jens,J. ,  LOOMIS, Maria-Cristina ,  DUTZAR, Benjamin, H. ,  GARCIA-MARTINEZ, Leon

IPC分类号： C07K16/18 ,  A61P25/06 ,  A61K38/00

CPC分类号： C07K16/26 ,  A61K39/3955 ,  A61K39/39566 ,  A61K45/06 ,  A61K49/0004 ,  A61K49/0008 ,  A61K2039/505 ,  C07K16/4241 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/5088 ,  G01N33/74 ,  G01N2333/5757 ,  Y02A50/383

摘要： This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.