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公开(公告)号：EP2709663B1
公开(公告)日：2019-03-20
申请号：EP12790022.3
申请日：2012-05-21
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公开(公告)号：EP2709662B1
公开(公告)日：2019-07-31
申请号：EP12788717.2
申请日：2012-05-21
发明人： RUSSO, Andrew F. , KAISER, Eric A. , RECOBER, Ana , KUBURAS, Adisa , RADDANT, Ann C. , KOVACEVICH, Brian Robert , LATHAM, John A. , SMITH, Jeffrey T.L. , GARCIA-MARTINEZ, Leon F.
IPC分类号： A61K39/395 , A61K48/00 , A61K38/16 , A61K31/7088 , A61P1/12 , C07K16/26 , A61K45/06 , A61K39/00
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3.发明公开USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO PREVENT OR INHIBIT PHOTOPHOBIA OR LIGHT AVERSION IN SUBJECTS IN NEED THEREOF, ESPECIALLY MIGRAINE SUFFERERS 审中-公开使用抗CGRP抗体以及防止或抑制照片或恐惧症LICHTABNEIGUNG IN FACT任命人员的抗体片段，尤其是偏头痛患者
公开(公告)号：EP2709663A2
公开(公告)日：2014-03-26
申请号：EP12790022.3
申请日：2012-05-21
发明人： RUSSO, Andrew F. , KAISER, Eric A. , RECOBER, Ana , KUBURAS, Adisa , RADDANT, Ann C. , KOVACEVICH, Brian Robert , LATHAM, John A. , SMITH, Jeffrey T.L. , GARCIA-MARTINEZ, Leon F.
IPC分类号： A61K39/395 , C07K16/28 , G01N33/53 , A61P27/02 , A61P35/00
CPC分类号： C07K16/18 , A61K2039/505 , Y02A50/383
摘要： The present invention also provides assays using transgenic Nestin/Ramp1 rodents, utilizing a CGRP model light aversive behavior model for identifying therapeutically effective anti-CGRP antibodies and fragments thereof having binding specificity for CGRP which inhibit or prevent photophobia in subjects in need thereof. The present invention is specifically directed to methods for identifying therapeutically effective antibodies and fragments thereof having binding specificity for CGRP that may be used to treat CGRP associated disorders such as migraine. Specifically, this invention relates to assays and therapies using the antibodies described herein to inhibit or prevent photophobia, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them.
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4.发明公开USE OF ANTI-CGRP OR ANTI-CGRP-R ANTIBODIES OR ANTIBODY FRAGMENTS TO TREAT OR PREVENT CHRONIC AND ACUTE FORMS OF DIARRHEA 审中-公开抗CGRP或抗CGRP-R抗体或抗体片段治疗慢性治疗或预防与急性腹泻使用形式
公开(公告)号：EP2709662A1
公开(公告)日：2014-03-26
申请号：EP12788717.2
申请日：2012-05-21
发明人： RUSSO, Andrew F. , KAISER, Eric A. , RECOBER, Ana , KUBURAS, Adisa , RADDANT, Ann C. , KOVACEVICH, Brian Robert , LATHAM, John A. , SMITH, Jeffrey T.L. , GARCIA-MARTINEZ, Leon F.
IPC分类号： A61K39/395 , A61K48/00 , A61K38/16 , A61K31/7088 , A61P1/12
CPC分类号： A61K45/06 , A61K2039/505 , C07K16/26 , C07K2317/24 , C07K2317/76 , Y02A50/487
摘要： The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for CGRP. In particular the methods prevent or reduce diarrhea in conditions or treatments resulting in elevated CGRP levels, e.g., in the GI tract (colon) that are associated with diarrhea and/or improper electrolyte and fluid excretion from the bowel or urinary system. More specifically, this invention relates to treatments using the anti-CGRP antibodies and fragments described herein, and binding fragments thereof.
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