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公开(公告)号：EP1409070A2
公开(公告)日：2004-04-21
申请号：EP02739599.5
申请日：2002-05-31
发明人： SCHULMAN, Joseph, H. , FEY, Kate, E. , BYERS, Charles, L. , ZILBERMAN, Yitzhak , DELL, Robert, D. , KUZMA, Janusz
IPC分类号： A61N1/00
CPC分类号： A61N1/3752 , A61N1/05 , A61N1/37205
摘要： The invention discloses methods of making electrical connections in living tissue between an electrically conductive wire (40) and an implantable miniature device (2). The device may either stimulate muscles or nerves in the body or detect signals and transmit these signals outside the body or transmit the signals for use at another location within the body. The device is comprised of an electrically insulating or electrically conductive case with at least one electrode for transmitting electrical signals. The electrodes and the wire-electrode connections are protected from the aggressive environment within the body to avoid corrosion of the electrode and to avoid damage to the living tissue surrounding the device.
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2.发明授权
公开(公告)号：EP1404405B1
公开(公告)日：2012-04-11
申请号：EP02739717.3
申请日：2002-06-05
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/04
摘要： An implantable miniature eyelid electrode apparatus (2) that causes a paralyzed eyelid (9) to close or open by passing an electrical stimulating current to a nerve or muscle, is comprised of a longtudinally flexible, nonconductive body containing electrodes that pass an electrical signal to the nearby nerve or muscle, which closes or opens the eyelid.
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公开(公告)号：EP1409070B1
公开(公告)日：2010-12-22
申请号：EP02739599.5
申请日：2002-05-31
发明人： SCHULMAN, Joseph, H. , FEY, Kate, E. , BYERS, Charles, L. , ZILBERMAN, Yitzhak , DELL, Robert, D. , KUZMA, Janusz
CPC分类号： A61N1/3752 , A61N1/05 , A61N1/37205
摘要： The invention discloses methods of making electrical connections in living tissue between an electrically conductive wire (40) and an implantable miniature device (2). The device may either stimulate muscles or nerves in the body or detect signals and transmit these signals outside the body or transmit the signals for use at another location within the body. The device is comprised of an electrically insulating or electrically conductive case with at least one electrode for transmitting electrical signals. The electrodes and the wire-electrode connections are protected from the aggressive environment within the body to avoid corrosion of the electrode and to avoid damage to the living tissue surrounding the device.
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公开(公告)号：EP0272308A1
公开(公告)日：1988-06-29
申请号：EP87904451.0
申请日：1987-06-17
CPC分类号： A61B5/6852 , A61B5/0422 , A61B5/685 , A61N1/05 , Y10T29/49124
摘要： Le réseau d'électrodes est un dispositif permettant de réaliser des contacts électriques multiples avec des organes ou tissus cellulaires. Le réseau d'électrodes comprend une base (1), un réseau bidimensionnel de protubérances conductrices (2) faisant saillie depuis la base et servant d'électrodes, et des conducteurs (3) noyés sur la base et connectés à ces protubérances pour transmettre des signaux électriques vers les protubérances et/ou provenant des protubérances. Les protubérances peuvent également inclure une couche isolante (15) qui soit recouvre toute la protubérance soit laisse les pointes exposées pour réaliser un contact électrique focalisé. Les réseaux d'électrodes peuvent être utilisés seuls ou en combinaison avec un second réseau d'électrodes de manière à former un sandwich autour d'un tissu cible. Le réseau d'électrodes sandwich (16, 17) peut utiliser des cônes d'indexation pour aligner les réseaux d'électrodes opposés et pour limiter leur proximité verticale. Les conducteurs du réseau d'électrodes peuvent être connectés ou couplés électroniquement à un circuit de traitement qui amplifie et analyse le signal reçu du tissu et/ou qui génère des signaux lesquels sont envoyés au tissu cible, ce circuit de traitement pouvant aussi assurer une coordination entre les signaux générés et les signaux émanant du tissu.
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5.发明授权ELECTRICALLY SENSING AND STIMULATING SYSTEM FOR PLACEMENT OF A NERVE STIMULATOR OR SENSOR 有权电测和起搏系统用于放置在神经刺激器或传感器
公开(公告)号：EP1494583B1
公开(公告)日：2016-12-07
申请号：EP02786417.2
申请日：2002-10-16
发明人： SCHULMAN, Joseph, H. , BYERS, Charles, L. , WEISNER, Ralph, M. , CANFIELD, David, L. , FEY, Kate, E.
CPC分类号： A61N1/08 , A61B17/3468 , A61N1/0551
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公开(公告)号：EP2972130A2
公开(公告)日：2016-01-20
申请号：EP14767891.6
申请日：2014-03-14
IPC分类号： G01F1/74
CPC分类号： G01F1/56 , G01F1/7086 , G01F1/7088
摘要： A microfluidic flow rate sensor includes a droplet within a channel and a droplet movement detector that generates a signal based on the position and/or movement of the droplet within the channel. A processor determines the flow rate of a fluid through the channel based on the signal received from the droplet movement detector. In one example, the droplet movement detector is an optical detector, such as a combination of a lens and an image capturing device. In other examples, the droplet is electrically conductive, and at least a portion of the channel is conductive or includes electrical contacts. The position of the droplet within the channel is determined by observing the electrical characteristics of the channel.
摘要翻译： 微流体流量传感器包括通道内的液滴和液滴移动检测器，其基于通道内液滴的位置和/或运动产生信号。 处理器基于从液滴移动检测器接收的信号确定通过通道的流体的流速。 在一个示例中，液滴移动检测器是诸如透镜和图像捕获装置的组合的光学检测器。 在其他示例中，液滴是导电的，并且通道的至少一部分是导电的或包括电接触。 通过观察通道的电气特性来确定液滴在通道内的位置。
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7.发明公开IMPLANTABLE SHUNT SYSTEM AND ASSOCIATED PRESSURE SENSORS 审中-公开在ZUGEHÖRIGEDRUCKSENSOREN的IMPLANTIBARES SHUNTSYSTEM
公开(公告)号：EP2675343A2
公开(公告)日：2013-12-25
申请号：EP12710385.1
申请日：2012-02-16
发明人： SCHMIDT, Siegmar , BYERS, Charles, L. , JIANG, Guangqiang , DEARDEN, Brian , GORD, John , RODRIGUEZ, Daniel
CPC分类号： A61B5/031 , A61B5/0031 , A61B5/076 , A61B5/686 , A61B5/6864 , A61B5/6865 , A61B5/6868 , A61B2560/0219 , A61M27/006
摘要： A pressure sensor module configured for implant at a desired site at which a pressure is to be measured. The pressure sensor module includes a pressure sensitive membrane which is in direct contact with the environment at which a pressure is to be measured. The pressure sensor module forms a part of a pressure measuring system which uses a telemetry link between the pressure sensor module and an external controller for data transmission and transfer. The pressure measuring system provides a dual stage power and data transfer capability for use with an implantable system. An exemplary use is in a three pressure sensor system including a flow control valve in a shunt to treat hydrocephalus. An embodiment of the invention includes a pressure sensor and associated electromagnetic coils embedded in the tip portion of the shunt for measuring the pressure of fluid externally of the shunt at the tip portion.
摘要翻译： 一种气密密封的生物相容性压力传感器模块，其构造成用于在要测量压力的期望位置处植入。 具有相似热膨胀系数的压力模块封装部件的阳极接合提供低应力结合并保持长期可靠性，可靠性和准确性。 压力传感器模块包括与要测量压力的环境直接接触的压敏膜。 压力传感器模块形成压力测量系统的一部分，其使用压力传感器模块和外部控制器之间的遥测连接进行数据传输和传送。 压力传感器模块的工作电源由外部控制器和内部可再充电能量存储部件提供。 因此，压力测量系统提供与可植入系统一起使用的双级功率和数据传输能力。 压力传感器模块的示例性使用是在包括用于治疗脑积水的分流器中的流量控制阀的三压力传感器系统中。 在压力传感器模块中使用集成电路芯片和具有可选铁氧体磁芯的内部线圈提供低功耗和可靠的信号处理。 本发明的实施例包括压力传感器和嵌入在分流器的末端部分中的相关电磁线圈，用于测量在尖端部分处的分流器外部的流体的压力。
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8.发明公开ELECTRICALLY SENSING AND STIMULATING SYSTEM FOR PLACEMENT OF A NERVE STIMULATOR OR SENSOR 有权电测和起搏系统用于放置在神经刺激器或传感器
公开(公告)号：EP1494583A1
公开(公告)日：2005-01-12
申请号：EP02786417.2
申请日：2002-10-16
发明人： SCHULMAN, Joseph, H. , BYERS, Charles, L. , WEISNER, Ralph, M. , CANFIELD, David, L. , FEY, Kate, E.
IPC分类号： A61B5/05
CPC分类号： A61N1/08 , A61B17/3468 , A61N1/0551
摘要： The invention is directed to an electrically sensing and stimulating outer sheath (116) for ensuring accurate surgical placement of a microsensor (102) or a microstimulator (122) near a nerve (106) in living tissue. The electrically sensing outer sheath (116) may also be used to verify the function of the microstimulator (122) during surgical placement but before the outer sheath (116) is removed. In the event that the microstimulator (122) is not optimally placed near the nerve, or if the microstimulator (122) is malfunctioning, this can be determined prior to removal of the outer sheath (116), thus reducing the possibility of nerve or tissue damage that might be incurred during a separate operation to remove the microstimulator (122).
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