公开(公告)号：EP2790721B1

公开(公告)日：2018-10-17

申请号：EP12829142.4

申请日：2012-12-14

申请人： Alizé Pharma SAS

发明人： VAN DER LELY, Aart Jan ,  ABRIBAT, Thierry

IPC分类号： A61K38/08 ,  A61K38/12 ,  A61K38/25 ,  G01N33/74 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07K14/575 ,  A61K38/08 ,  A61K38/12 ,  A61K38/2264 ,  A61K38/25 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  G01N33/74 ,  G01N2333/62 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/52

摘要： A method and a composition for decreasing ghrelin levels and/or decreasing ghrelin/unacylated ghrelin ratio in a subject, the method comprising administering an effective amount of unacylated ghrelin, a fragment thereof, an analog thereof and/or pharmaceutically acceptable salts thereof to the subject wherein a reduction in ghrelin levels and/or a reduction in ghrelin/unacylated ghrelin ratio is beneficial to the subject. Also, use of ghrelin level and/or ghrelin/unacylated ghrelin ratio as biomarkers for determining a subject's likelihood of responding to and/or benefiting from administration of unacylated ghrelin.

公开(公告)号：EP2790721A1

公开(公告)日：2014-10-22

申请号：EP12829142.4

申请日：2012-12-14

申请人： Alizé Pharma SAS

发明人： VAN DER LELY, Aart Jan ,  ABRIBAT, Thierry

IPC分类号： A61K38/25 ,  G01N33/50 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07K14/575 ,  A61K38/08 ,  A61K38/12 ,  A61K38/2264 ,  A61K38/25 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  G01N33/74 ,  G01N2333/62 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/52

摘要： A method and a composition for decreasing ghrelin levels and/or decreasing ghrelin/unacylated ghrelin ratio in a subject, the method comprising administering an effective amount of unacylated ghrelin, a fragment thereof, an analog thereof and/or pharmaceutically acceptable salts thereof to the subject wherein a reduction in ghrelin levels and/or a reduction in ghrelin/unacylated ghrelin ratio is beneficial to the subject. Also, use of ghrelin level and/or ghrelin/unacylated ghrelin ratio as biomarkers for determining a subject's likelihood of responding to and/or benefiting from administration of unacylated ghrelin.

摘要翻译： 一种方法，以及用于降低生长素释放肽的水平和/或在受试者中降低生长素释放肽/未酰化的生长素释放肽比的组合物，包含有效量的未酰化的生长素释放肽的施用方法，其片段，模拟物和/或药学上可接受的盐至所述受试者 worin在生长素释放肽水平和/或生长素释放肽中的减少的减少/未酰化的生长素释放肽比是给受试者有益的。 所以，使用生长素释放肽水平和/或生长素释放肽/生长素释放肽比未酰化作为生物标志物用于确定性采矿响应和/或生长素释放肽从未酰化的给药中受益的受试者的可能性。