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公开(公告)号：EP3441395A1
公开(公告)日：2019-02-13
申请号：EP18195989.1
申请日：2015-05-14
IPC分类号： C07F7/18
摘要： A method of forming a compound of formula (II) in which a compound of formula (I) is reacted with less than a molar equivalent of a compound of formula (V):
wherein R 1 in each occurrence is independently selected from H, halogen, amino, C 1-5 alkyl, C 2-5 alkenyl and C 2-5 alkynyl; R 2 in each occurrence is independently selected from H, halogen, amino, C 1-5 alkyl, C 2-5 alkenyl and C 2-5 alkynyl; R 3 in each occurrence is independently selected from the group consisting of C 1-5 alkoxy and C 1-10 hydrocarbyl; and R 5 is C 1-5 alkyl.-
公开(公告)号：EP3231806A1
公开(公告)日：2017-10-18
申请号：EP17168966.4
申请日：2015-05-14
IPC分类号： C07D499/87
CPC分类号： C07D499/87 , C07F7/1896 , Y02P20/55
摘要： A method of forming a compound of formula (IV) comprising the step of reacting a compound of formula (III) with a 2-ethylhexanoate salt:
wherein R 1 in each occurrence is independently selected from H, halogen, amino, C 1-5 alkyl, C 2-5 alkenyl and C 2-5 alkynyl; R 2 in each occurrence is independently selected from H, halogen, amino, C 1-5 alkyl, C 2-5 alkenyl and C 2-5 alkynyl; and R 4 is C 1-5 alkyl; X- is an anion and each R 3 is independently selected from the group consisting of C 1-10 hydrocarbyl and C 1-5 alkoxy.摘要翻译： 形成式（IV）化合物的方法包括使式（III）化合物与2-乙基己酸盐反应的步骤：其中R 1在每种情况下独立地选自H，卤素，氨基，C 1-5烷基， C2-5链烯基和C2-5炔基; R 2在每次出现时独立地选自H，卤素，氨基，C 1-5烷基，C 2-5烯基和C 2-5炔基; 和R4是C1-5烷基; X-是阴离子，每个R3独立地选自C1-10烃基和C1-5烷氧基。
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公开(公告)号：EP3143028B1
公开(公告)日：2018-09-26
申请号：EP15726552.1
申请日：2015-05-14
IPC分类号： C07D499/87
CPC分类号： C07D499/87 , C07F7/1896 , Y02P20/55
摘要： A method of forming a compound of formula (IV) comprising the step of reacting a compound of formula (III) with a 2-ethylhexanoate salt: wherein R 1 in each occurrence is independently selected from H, halogen, amino, C 1-5 alkyl, C 2-5 alkenyl and C 2-5 alkynyl; R 2 in each occurrence is independently selected from H, halogen, amino, C 1-5 alkyl, C 2-5 alkenyl and C 2-5 alkynyl; and R 4 is C 1-5 alkyl; X- is an anion and each R 3 is independently selected from the group consisting of C 1-10 hydrocarbyl and C 1-5 alkoxy.
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公开(公告)号：EP3143028A2
公开(公告)日：2017-03-22
申请号：EP15726552.1
申请日：2015-05-14
IPC分类号： C07D499/87
CPC分类号： C07D499/87 , Y02P20/55
摘要： A method of forming a compound of formula (IV) comprising the step of reacting a compound of formula (III) with a 2-ethylhexanoate salt: wherein R 1 in each occurrence is independently selected from H, halogen, amino, C 1-5 alkyl, C 2-5 alkenyl and C 2-5 alkynyl; R 2 in each occurrence is independently selected from H, halogen, amino, C 1-5 alkyl, C 2-5 alkenyl and C 2-5 alkynyl; and R 4 is C 1-5 alkyl; X- is an anion and each R 3 is independently selected from the group consisting of C 1-10 hydrocarbyl and C 1-5 alkoxy.
摘要翻译： 形成式（IIIa）化合物的方法; 其中：R 1在每次出现时独立地选自H，卤素，氨基，C 1-5烷基，C 1-5烯基和C 1-5炔基; R2各自独立地选自H，卤素，氨基，C 1-5烷基，C 1-5烯基和C 1-5炔基; R4是C1-5烷基; 并且R 6是C 1-5氟烷基; PG是保护基，该方法包括使式（Ⅰaa）化合物与式（Ⅷ）化合物反应的步骤。
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