公开(公告)号：EP3324890A1

公开(公告)日：2018-05-30

申请号：EP16828696.1

申请日：2016-07-25

申请人： Allergan, Inc.

发明人： NAVRATIL, Tomas ,  DAS, Sanjib ,  GARCIA, Andres ,  TULLY, Janet

IPC分类号： A61F2/16 ,  A61K31/5575 ,  A61P27/06

CPC分类号： A61F9/00781 ,  A61F9/0017 ,  A61K9/0051 ,  A61K9/70 ,  A61K31/5575 ,  A61K45/06 ,  A61K47/34 ,  G01N2800/168 ,  A61K2300/00

摘要： The disclosure teaches methods of utilizing precisely engineered biodegradable drug delivery systems to treat ocular conditions. In aspects, the disclosure provides methods of treating elevated intraocular pressure with intracameral implants administered to the anterior region of an eye. Furthermore, the disclosure provides for methods of lowering intraocular pressure in a subject, by administering intracameral implants that maintain a multi-month sustained level of travoprost acid in the aqueous humor of said subject' eye, which is at least 8x lower than the EC50 values of travoprost acid on its molecular target, but yet still achieves clinically significant lowering of IOP.