公开(公告)号：EP1709007A1

公开(公告)日：2006-10-11

申请号：EP05701549.7

申请日：2005-01-19

申请人： Altana Pharma AG

发明人： BARSIG, Johannes ,  BAUDLER, Monika ,  BUNDSCHUH, Daniela ,  GANTNER, Florian ,  GRAEDLER, Ulrich ,  HEIT, Isabelle ,  MARTIN, Thomas ,  SCHAEFER, Michaela ,  SCHLEMMINGER, Imre ,  STADLWIESER, Josef ,  ULRICH, Wolf-Ruediger

IPC分类号： C07D239/42 ,  C07D409/14 ,  C07D403/04 ,  C07D405/04 ,  A61K31/505 ,  A61K31/506 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D239/42 ,  C07D403/04 ,  C07D405/04 ,  C07D409/14

摘要： Compounds of a certain formula 1 in which R1 and R2 have the meanings indicated in the description are novel kinase inhibitors. Formula (1), in which R1 is phenyl, phenyl substituted by R3 and/or R4, naphthalenyl, naphthalenyl substituted by R5 and/or R6, aryl1, aryl1 substituted by R7 and/or R8, R9, R10 or R11, R2 is phenyl, phenyl substituted by R12 and/or R13, naphthalenyl, naphthalenyl substituted by R14 and/or R15, aryl2, aryl2 substituted by R16 and/or R17 or a radical selected from Formula (2).

公开(公告)号：EP1515964A1

公开(公告)日：2005-03-23

申请号：EP03735581.5

申请日：2003-06-07

申请人： ALTANA Pharma AG ,  Signal Pharmaceuticals, Inc.

发明人： BAUDLER, Monika ,  BHAGWAT, Shripad, S. ,  ERDMAN, Paul, E. ,  GANTNER, Florian ,  PALANKI, Moorthy S., S. ,  SCHUDT, Christian ,  STADLWIESER, Josef ,  ZAPF, James

IPC分类号： C07D401/14 ,  C07D409/14 ,  A61K31/506 ,  A61P11/00 ,  C07D405/14

CPC分类号： C07D409/14 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

摘要： The invention relates to substituted diaminopyrimidine compounds, which are effective therapeutic compounds for treating diseases and disorders associated with those commonly treated by Protein Kinase C theta (PKCtheta) inhibitors.

摘要翻译： 本发明涉及取代的二氨基嘧啶化合物，其是治疗与通常由蛋白激酶Cθ（PKCθ）抑制剂治疗的疾病和病症有关的疾病和病症的有效治疗性化合物。