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公开(公告)号：EP3529263A1
公开(公告)日：2019-08-28
申请号：EP17861811.2
申请日：2017-10-21
发明人： WONG, Hing, C. , MARCUS, Warren , LIU, Bai , XU, Wenxin , NEWMAN, Robby , KAGE, Karen , YOU, Lijing , RHODE, Peter , SOON-SHIONG, Patrick
IPC分类号： C07K14/54 , C07K14/705 , C07K16/18 , C07K14/715 , C07K14/435 , C07K14/47 , C07K16/24 , C07K16/28 , C07K16/30 , C07K16/32
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公开(公告)号：EP3851459A1
公开(公告)日：2021-07-21
申请号：EP21152304.8
申请日：2011-09-21
发明人： WONG, Hing C. , RHODE, Peter , LIU, Bai , ZHU, Xiaoyun , HAN, Kai-Ping
IPC分类号： C07K19/00 , C07K14/54 , C07K14/075 , C12N15/62 , A61K38/17 , A61P35/00 , C12N1/00 , C12N5/00 , A61K38/00 , C07K14/715 , A61K38/20 , C07K16/18
摘要： The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
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3.发明公开MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME 有权可溶性聚IL-15融合分子和方法的生产和使用
公开(公告)号：EP2619229A2
公开(公告)日：2013-07-31
申请号：EP11827439.8
申请日：2011-09-21
发明人： WONG, Hing, C. , RHODE, Peter , LIU, Bai , ZHU, Xiaoyun , HAN, Kai-ping
CPC分类号： C07K14/7155 , A61K38/00 , A61K38/1793 , A61K38/2086 , A61K39/3955 , A61K45/06 , C07K14/5443 , C07K16/18 , C07K16/2887 , C07K2317/622 , C07K2317/732 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C12N15/09 , C12N15/62 , C12P21/00 , A61K2300/00
摘要： The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin- 15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
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公开(公告)号：EP3912637A1
公开(公告)日：2021-11-24
申请号：EP21173707.7
申请日：2015-06-30
发明人： LIU, Bai , RHODE, Peter , XU, Wenxin , WONG, Hing C.
IPC分类号： A61K39/00 , A61K39/385 , A61P35/00
摘要： The invention features combination therapies using an IL-15-based superagonist complex and an anti-PD-1 antibody to effectively treat subjects with non-small cell lung cancer.
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公开(公告)号：EP3327040A1
公开(公告)日：2018-05-30
申请号：EP17200359.2
申请日：2011-09-21
发明人： WONG, Hing C. , RHODE, Peter , LIU, Bai , ZHU, Xiaoyun , HAN, Kai-ping
IPC分类号： C07K19/00 , C07K14/54 , C07K14/075 , C12N15/62 , A61K38/17 , A61P35/00 , C12N1/00 , C12N5/00 , A61K38/00 , C07K14/715 , A61K38/20 , C07K16/18 , A61K45/06 , C07K16/28 , C12P21/00 , C12N15/09
CPC分类号： C07K14/7155 , A61K38/00 , A61K38/1793 , A61K38/2086 , A61K39/3955 , A61K45/06 , C07K14/5443 , C07K16/18 , C07K16/2887 , C07K2317/622 , C07K2317/732 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C12N15/09 , C12N15/62 , C12P21/00 , A61K2300/00
摘要： The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
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公开(公告)号：EP2411545B1
公开(公告)日：2017-03-08
申请号：EP10756833.9
申请日：2010-03-25
IPC分类号： C12Q1/70
CPC分类号： C07K14/70503 , C07K14/705 , C07K14/7051 , G01N33/56988
摘要： The instant invention provides TCRs having one or more amino acid substitutions that bind to the AL9 epitope of the HIV protein vpr (AIIRILQQL (SEQ ID NO: 1)).
摘要翻译： 本发明提供了具有与HIV蛋白质vpr（AIIRILQQL（SEQ ID NO：1））的AL9表位结合的一个或多个氨基酸取代的TCR。
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公开(公告)号：EP3592778A1
公开(公告)日：2020-01-15
申请号：EP18764359.8
申请日：2018-03-06
发明人： MARCUS, Warren, D. , NEWMAN, Robert , LIU, Bai , YOU, Lijing , KONG, Lin , RHODE, Peter , WONG, Hing, C.
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8.发明授权MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME 有权可溶性聚IL-15融合分子和方法的生产和使用
公开(公告)号：EP2619229B1
公开(公告)日：2016-04-06
申请号：EP11827439.8
申请日：2011-09-21
发明人： WONG, Hing, C. , RHODE, Peter , LIU, Bai , ZHU, Xiaoyun , HAN, Kai-ping
IPC分类号： C07K19/00 , C07K14/54 , C07K14/075 , C12N15/62 , A61K38/17 , A61P35/00 , A61K38/20 , C07K16/18 , C12N1/00 , C12N5/00 , A61K38/00 , C07K14/715
CPC分类号： C07K14/7155 , A61K38/00 , A61K38/1793 , A61K38/2086 , A61K39/3955 , A61K45/06 , C07K14/5443 , C07K16/18 , C07K16/2887 , C07K2317/622 , C07K2317/732 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C12N15/09 , C12N15/62 , C12P21/00 , A61K2300/00
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公开(公告)号：EP3601363A1
公开(公告)日：2020-02-05
申请号：EP18776459.2
申请日：2018-03-30
发明人： SHRESTHA, Niraj , LIU, Bai , RHODE, Peter , WONG, Hing, C.
IPC分类号： C07K16/28 , C07K16/18 , C07K14/54 , C07K14/715 , A61K38/20 , A61K38/19 , A61K38/17 , A61K39/395
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10.发明公开
公开(公告)号：EP3464352A1
公开(公告)日：2019-04-10
申请号：EP17803651.3
申请日：2017-05-26
发明人： LIU, Bai , RHODE, Peter , WONG, Hing, C.
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