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公开(公告)号：EP1499291B1
公开(公告)日：2009-01-07
申请号：EP03728526.9
申请日：2003-04-25
申请人： ALZA Corporation
发明人： AYER, Atul , SHIVANAND, Padmaja , MODI, Nishit, B. , SEROFF, Sonya , DESJARDIN, Michael, A. , FINK, Tracy, A. , HEARNEY, Linda, M. , JOHNSON, Deborah, J. , ALLPHIN, Clark, P.
CPC分类号： A61K9/0004 , A61K31/485
摘要： Dosage forms and methods for the controlled release of oxycodone over a prolonged period of time are described. The sustained release dosage forms provide therapeutically effective average steady-state plasma oxycodone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma oxycodone concentration occurrence in each 24 hour period that occurs at a later time after administration and exhibits a lesser magnitude than the peak plasma oxycodone concentration that occurs following administration of oxycodone in an immediate-release dosage form and other prior art extended release dosage forms.
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公开(公告)号：EP1499291A1
公开(公告)日：2005-01-26
申请号：EP03728526.9
申请日：2003-04-25
申请人： Alza Corporation
发明人： AYER, Atul , SHIVANAND, Padmaja , MODI, Nishit, B. , SEROFF, Sonya , DESJARDIN, Michael, A. , FINK, Tracy, A. , HEARNEY, Linda, M. , JOHNSON, Deborah, J. , ALLPHIN, Clark, P. , RASHID, Ayesha
CPC分类号： A61K9/0004 , A61K31/485
摘要： Dosage forms and methods for the controlled release of oxycodone over a prolonged period of time are described. The sustained release dosage forms provide therapeutically effective average steady-state plasma oxycodone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma oxycodone concentration occurrence in each 24 hour period that occurs at a later time after administration and exhibits a lesser magnitude than the peak plasma oxycodone concentration that occurs following administration of oxycodone in an immediate-release dosage form and other prior art extended release dosage forms.
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