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公开(公告)号：EP1499291B1
公开(公告)日：2009-01-07
申请号：EP03728526.9
申请日：2003-04-25
申请人： ALZA Corporation
发明人： AYER, Atul , SHIVANAND, Padmaja , MODI, Nishit, B. , SEROFF, Sonya , DESJARDIN, Michael, A. , FINK, Tracy, A. , HEARNEY, Linda, M. , JOHNSON, Deborah, J. , ALLPHIN, Clark, P.
CPC分类号： A61K9/0004 , A61K31/485
摘要： Dosage forms and methods for the controlled release of oxycodone over a prolonged period of time are described. The sustained release dosage forms provide therapeutically effective average steady-state plasma oxycodone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma oxycodone concentration occurrence in each 24 hour period that occurs at a later time after administration and exhibits a lesser magnitude than the peak plasma oxycodone concentration that occurs following administration of oxycodone in an immediate-release dosage form and other prior art extended release dosage forms.
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公开(公告)号：EP1898883A2
公开(公告)日：2008-03-19
申请号：EP06785698.9
申请日：2006-06-22
申请人： ALZA CORPORATION
发明人： ROHLOFF, Catherine, Manya , CHEN, Guohua , DING, Zhongli , BERRY, Stephen, Andrew , NARAYANAN, Latha, Pisharody , DESJARDIN, Michael, A.
IPC分类号： A61K9/16 , A61K47/14 , A61K47/10 , A61K47/44 , A61K47/26 , A61K47/32 , A61K47/12 , A61K47/08
CPC分类号： A61K47/32 , A61K9/0019 , A61K9/1617 , A61K9/1623 , A61K9/1688 , A61K38/27 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/22 , A61K47/26 , A61K47/34 , A61K47/44
摘要： Formulations and methods are provided for improving the stability upon exposure to aqueous media of polypeptides present in non-aqueous suspension vehicles. In particular aspects of the invention, formulations are provided that comprise a complex of a metal ion and a polypeptide suspended in a non-aqueous, biocompatible suspension vehicle. Aggregation of individual polypeptide molecules is reduced when aqueous media is introduced to such formulations, serving to stabilize the polypeptide.
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3.发明授权DOSAGE FORMS AND METHODS FOR PROVIDING EFFECTIVE REBOXETINE THERAPY WITH ONCE-A-DAY DOSING 有权剂型和以“一天一次”剂量的方法对于一个有效的REBOXETINTHERAPIE
公开(公告)号：EP1216031B1
公开(公告)日：2007-03-14
申请号：EP00963500.4
申请日：2000-09-15
申请人： ALZA CORPORATION
发明人： SEROFF, Sylvia , YAM, Noymi , AYER, Atul, D. , BHATT, Padmanabh , DESJARDIN, Michael, A. , LAM, Andrew, C. , EDGREN, David, E. , NIXON, Phillip, R.
IPC分类号： A61K9/22
CPC分类号： A61K31/5375 , A61K9/0004
摘要： Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxetine concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma reboxetine concentration occurrence in each 24 hour period. In addition, the peak plasma reboxetine concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma reboxetine concentration that occurs following administration of reboxetine in an immediate-release dosage form.
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4.发明公开DOSAGE FORMS AND METHODS FOR PROVIDING EFFECTIVE REBOXETINE THERAPY WITH ONCE-A-DAY DOSING 有权剂型和以“一天一次”剂量的方法对于一个有效的REBOXETINTHERAPIE
公开(公告)号：EP1216031A2
公开(公告)日：2002-06-26
申请号：EP00963500.4
申请日：2000-09-15
申请人： Alza Corporation
发明人： SEROFF, Sylvia , YAM, Noymi , AYER, Atul, D. , BHATT, Padmanabh , DESJARDIN, Michael, A. , LAM, Andrew, C. , EDGREN, David, E. , NIXON, Phillip, R.
IPC分类号： A61K9/22
CPC分类号： A61K31/5375 , A61K9/0004
摘要： Dosage forms and methods for providing sustained release of reboxetine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma reboxetine concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma reboxetine concentration occurrence in each 24 hour period. In addition, the peak plasma reboxetine concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma reboxetine concentration that occurs following administration of reboxetine in an immediate-release dosage form.
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5.发明公开STABLE, NON-AQUEOUS, SINGLE-PHASE GELS AND FORMULATIONS THEREOF FOR DELIVERY FROM AN IMPLANTABLE DEVICE 审中-公开稳定化的非水单相凝胶和含给药的组合物可植入装置
公开(公告)号：EP1578398A2
公开(公告)日：2005-09-28
申请号：EP03813829.3
申请日：2003-12-19
申请人： ALZA CORPORATION
CPC分类号： A61K9/0004 , A61K9/0024 , A61K47/26 , A61L24/001
摘要： The present invention provides a suspension vehicle and suspension formulations deliverable from an implantable delivery device. In particular, the suspension vehicle of the present invention allows the formulation of beneficial agent suspensions that are stable over time at ambient and physiological temperatures. In addition, the beneficial agent suspensions formed using the suspension vehicle of the present invention allow controlled delivery of beneficial agent from an implanted delivery device over sustained periods of time, even when such delivery occurs at low flow rates, through a small-diameter delivery channel. Also included in the present invention are implantable delivery devices.
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公开(公告)号：EP1499291A1
公开(公告)日：2005-01-26
申请号：EP03728526.9
申请日：2003-04-25
申请人： Alza Corporation
发明人： AYER, Atul , SHIVANAND, Padmaja , MODI, Nishit, B. , SEROFF, Sonya , DESJARDIN, Michael, A. , FINK, Tracy, A. , HEARNEY, Linda, M. , JOHNSON, Deborah, J. , ALLPHIN, Clark, P. , RASHID, Ayesha
CPC分类号： A61K9/0004 , A61K31/485
摘要： Dosage forms and methods for the controlled release of oxycodone over a prolonged period of time are described. The sustained release dosage forms provide therapeutically effective average steady-state plasma oxycodone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma oxycodone concentration occurrence in each 24 hour period that occurs at a later time after administration and exhibits a lesser magnitude than the peak plasma oxycodone concentration that occurs following administration of oxycodone in an immediate-release dosage form and other prior art extended release dosage forms.
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